Tag: "turning" at biology news

Genetic mutations linked to the practice of burning coal in homes in China

...or suppressor gene that prevents normal cells from turning into tumor cells, and K-ras, an oncogene, is fundamental to the development of a vast majority of cancers. Mutations to both p53 and K-ras are thought to be primarily caused by chemicals called polycyclic aromatic hydrocarbons that are emitted during...

Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases

...cked down by the immune system. The challenge with turning listeria into a vaccine was to retain its ability to stimulate a strong immune system attack, yet reduce its ability to spread from cell to cell and cause toxicity, Portnoy said. Listeria bacteria establish an infection by inducing immune system cell...

Master of antimalarial resistance

...Normally, the parasite detoxifies the free heme by turning it into a product called hemozoin. As an antimalarial drug, chloroquine works by blocking this detoxification process. The protein produced by the pfcrt gene is located in this digestive vacuole and may act as its gatekeeper. In chloroquine-resistant...

A novel, safer strategy for regulating gene expression

... and safer system for controlling gene expression turning genes on and off as needed that involves an inter... is cut in half, too disabling it and, in effect, turning off the gene. Inhibiting ribozyme breakage, which can be done with various drugs, leaves the mRNA in...

AACR applauds NCI initiative on nanotechnology

...spread, scientists and clinicians increasingly are turning to smaller and smaller probes that not only act as microscopic sentinels, but also as tools capable of interfering with these processes. For this reason, the American Association for Cancer Research applauds the new initiative announced today by the ...

Sugar-coated sea urchin eggs could have sweet implications for human fertility

...ocean depths, so there is little chance of hybrids turning up. But in other places, such as the waters off the West Coast of North America, the species breed at the same time and occupy the same waters, and still hybrids are rare. The purple sea urchin has been the most closely studied of the urchins and fo...

Images of 'tail' of protein needed for cell multiplication suggest anticancer drug targets

...f drugs targeting the tail or the workshop itself, turning off the unrestrained multiplication of cancer cells. The study also shows that a slight change in a structure common among many enzymes performing similar jobs can create a new enzyme with a unique activity. The St. Jude researchers report that the ...

Researchers identify the genome's controlling elements

...st for a 747 airplane--scientists are increasingly turning their attention to figuring out how living organisms put their genes to work. Using yeast as a testing ground, researchers at Whitehead Institute for Biomedical Research have for the first time revealed all the "controlling elements" of an entire gen...

Other highlights in the September 1 JNCI

...ed proteins, but such cells survive this stress by turning on a special molecular pathway--the unfolded protein response--that protects cells from the harmful effects of unfolded proteins. Researchers have hypothesized that glucose-deprived tumor cells could be killed by disrupting this pathway. Kazuo Shin-y...

Marathoning mice could have Olympian effects on obesity

...uscle fibers that enhanced endurance exercise." By turning on PPAR-delta, the team had produced highly efficient muscle fibers that burned fat more rapidly. As a result, the mice were almost unable to gain weight even in the absence of exercise. "These muscles also provided resistance to obesity, despite th...

Anticancer drug zebularine specifically targets tumor cells

...n orally, and that it does this tumor-whittling by turning on tumor suppressor genes that had been turned off through methylation. "This was the first time this type of drug has been able to reactivate silenced genes through oral administration," noted Jones. This new study published in Cancer Cell not only ...

In gene regulation, small is beautiful

...ere as effective as a natural activation domain at turning on genes. Small molecules have great advantages as artificial gene regulators, said Mapp, who also will discuss the work Aug. 22 at a meeting of the American Chemical Society in Philadelphia. They are less likely than larger molecules to be degraded...

Progress in breast cancer progression

...a protein called NF-kB, which works in the cell by turning on a variety of other genes, is involved in tumor progression when its activity in the cell is altered. The authors showed that NF-kB is essential for the initial transition stage called epithelial-mesenchymal transition, which is thought to be impor...

Putting energy into heart protection

...op any biochemical pathways that use energy and by turning on processes that take up glucose and free fatty acids from their surroundings in order to rebuild their ATP reservoir. The main protein involved in this switch is called AMP-activated protein kinase (AMPK). One situation of obvious energy stress o...

JCI table of contents, 16 August, 2004

...op any biochemical pathways that use energy and by turning on processes that take up glucose and free fatty a...a protein called NF-kB, which works in the cell by turning on a variety of other genes, is involved in tumor progression when its activity in the cell is alter...

RNA could form building blocks for nanomachines

...structures for living things, many researchers are turning to biology for their inspiration and construction tools. "Biology builds beautiful nanoscale structures, and we'd like to borrow some of them for nanotechnology," Guo said. "The trouble is, when we're working with such tiny blocks, we are short of ti...

Discoveries in neuroscience

...ns grow, they can compensate for missing genes by turning other genes on or off and cooking up other protein recipes. These biochemical changes can make it difficult to recognize connexins' role. But mefloquine in adult mice precisely and potently blocks connexins called Cx36 and Cx50. There are about 20 ki...

Endangered turtles' trek along ocean currents revealed by satellite

...One made it to within 500 km of West Africa before turning back, another came close to Nova Scotia. "Then having either made it to the Gulf Stream area or to the equatorial belt, the turtles tend to slow down and follow the frontal areas associated with local ocean current systems, which are generally ...

Researchers look into components of RNA silencing machinery

...omatic. "Some soldiers carry the duty of turning off certain lights along the highway. Everybody ...ilencing machinery soldiers, someone else is still turning the lights off! We don't know who did it, but we're on our way to find out." "What we have s...

Putting GPS to work, researchers shed light on road-following by pigeons

...s may follow roadways and use highway landmarks as turning points in their flight. However, the challenge of accurately tracking the birds stood in the way of solid quantitative analysis. In the new work, miniaturized GPS "flight-loggers," which pigeons carried on their backs, allowed researchers a clear and...

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Breaking Medicine News(10 mins):Health News:Women with severe, chronic health issues are screened for breast cancer less often 2Health News:Theresa Caputo Tickets in Kalamazoo at Wings Stadium, Saenger Theatre in New Orleans, Kiva Auditorium in Albuquerque and Rapid City at Don Barnett Arena Now Available 2Health News:Professor Luciana Lagana Dedicates to Her CSUN Students the “Dr. Luciana Show-Aging and Falling” AOF Festival Nomination (Screening at Krikorian Monrovia Cinema on 08/25) 2Health News:Professor Luciana Lagana Dedicates to Her CSUN Students the “Dr. Luciana Show-Aging and Falling” AOF Festival Nomination (Screening at Krikorian Monrovia Cinema on 08/25) 3Health News:Professor Luciana Lagana Dedicates to Her CSUN Students the “Dr. Luciana Show-Aging and Falling” AOF Festival Nomination (Screening at Krikorian Monrovia Cinema on 08/25) 4Health News:ESMO honors outstanding oncology professionals 2Health News:ESMO honors outstanding oncology professionals 3Health News:Many patients are discharged without a diagnosis 2
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