Crystal Structure Of Key HIV Protein Reveals New Treatment Targets
In a finding that unlocks new doors to devising drugs and vaccines against HIV,scientists have crystallized the core of gp120, the surface protein moleculethat the virus uses to attach itself to immune system cells. The new model of the gp120 core's crystal structure reveal...Security Code Helps Immune Cells Attack Foe And Spare Self
...phates are added in a specific order. The codethat unlocks the door is: B1, C2, A1, A2, B2, C1. A helper cell becomes fully active only when all six phosphates are inplace. But the two resting-state phosphates may prime the pump, Allen says. The study suggests that punching in the security ...... ultravioletradiation, a cell protein called RecA unlocks that section, permittingproduction of the umu proteins in what is called the "SOS response." "What everyone assumed," says Goodman, "was that these umu proteins somehowinhibited, or interfered with, the DNA copying enzymes and somehow lowered thecopy...Key step in gene activation discovered
...p's most recent discovery, the molecular team that unlocks genes was known to include a protein called a "Transcription Activator," whose particular skill is the ability to find the gene that needs to be turned on among the hundreds of other genes and miscellaneous DNA material strung end-to-end along the wh...Research team unlocks secrets of the firefly flash
New study sheds light on firefliesresearch team unlocks secrets of the firefly flash Light fades from the summer sky, and the spectacular light show put on by thousands of fireflies begins. While these remarkable bioluminescent insects have inspired poets and delighted children for centuries, it has bee...University of Ulster spearheads giant leap forward in medicine
...n very low doses under laboratory conditions. This unlocks the potential for new drugs to help people suffering from high blood pressure. The same frog also produces a peptide which stops blood from clotting, opening the way for new treatments for Deep Vein Thrombosis - the so-called economy class syndrome ...Scientists unlock secret behind cause of chronic lung disease
...sence of foreign bodies or disease, the Hck enzyme unlocks and becomes active. The active molecule then signals the macrophage to start defending the lung against disease. The Ludwig team made a change to one amino acid in the Hck enzyme of mice that forced the enzyme into a permanently active state. Ander...Experimental cancer drugs may halt events that lead to cardiac hypertrophy and heart failure
...rotect the heart from hypertrophy. In effect, HDAC unlocks genes that have been kept hidden since birth. "This genetic control of cell growth is why HDAC inhibitors also make for promising anti-cancer drugs," said Epstein. "Although we do not know for certain what this genetic program entails, it clearly ...EGFR: A molecular lab rat let loose in systems biology
...membranes. Clicking the deadbolt either blocks or unlocks the desired reaction in the cell. It turns out that a strong and decisive snap of the bolts -- the high-affinity binding -- works for a while, but keeping the arrangement in place can drain the system. "In one case, we were able to predict that a gr...Molecular level discovery could play role in development of new antibiotics
...required for antimicrobial activity. The discovery unlocks a door that could lead to a new line of antibiotic compounds based on nature's machinery, said Wilfred A. van der Donk, a professor of chemistry at Illinois. The work was done using lacticin 481, a lantibiotic produced by one of several strains of La...