Tag: "virulent" at biology news

Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases

...ive, identified the genes in listeria that make it virulent and, with Cerus scientists, knocked them out. The modified bacteria ignite a full-blown "innate" immune response in the vaccinated mice, but with a thousand-fold less toxicity than the wild bacteria. Cerus then took the genetically engineered listeri...

Algal contact as a trigger for coral disease

...limeda opuntia, is shown to trigger a particularly virulent disease known as white plague type II. In the Caribbean, a large number of coral colonies on which this alga was transplanted developed white plague whereas unexposed colonies did not. In addition, the plant was found to be a reservoir for the marin...

Missing genes may help explain why plague bacteria are so deadly

...volved "provide a sobering example of how a highly virulent epidemic (pathogen) can suddenly emerge from a les...ar events that led to the emergence of this highly virulent bacterium," said LLNL biologist Emilio Garcia, who headed the research team. Knowledge of the genet...

Smac-ing back at cancer cells

...ne of the most resilient and aggressive cancers a virulent brain cancer known as glioblastoma. The new approach to tricking the cell-death machinery could be applied to a wide range of cancers where this pathway, known as apoptosis, has been inactivated. The researchers -- led by Xiaodong Wang, a Howard Hug...

Stuck on you: Scientists lay bare secrets of bacterial attachment proteins

...e invasion. Together they define how aggressive or virulent the bacteria are at attacking the host. Most families of adhesins belong to bacteria that cause a single disease, but the 'Dr' family of Adhesins makes far more trouble: it is responsible for chronic diarrhoeal, intestinal and urinary tract infectio...

Study of flu patients reveals virus outsmarting key drug

...ity. In the event of an influenza pandemic, when a virulent new form of the flu virus emerges and poses a glob...adult human immune system exposed to the new, more virulent forms of flu virus at the root of pandemics. "Most of the children we looked at are younger than 3 y...

Scientists discover new intricacies in how ulcer bugs stick to stomach

... bacteria in Latin America. The protein is used by virulent strains of H. pylori that are the targets of a long-term vaccine development effort. "If we can improve our understanding of how H. pylori adheres to the stomach lining, we may be able to develop better ways to prevent or decrease infections," sa...

Tips from the Journals of the American Society for Microbiology

...ral vaccination against respiratory challenge with virulent Brucella and suggest that WR201 should be further ...01 protects mice against intranasal challenge with virulent Brucella melitensis 16M. Infection and Immunity, 72. 7: 4031-4039.) New Patch May Enhance Ef...

Finding the hole in the defenses of cavity-creating microbes

... discovered in a similar bug that causes a type of virulent pneumonia, in research by a group led by Charles Rock at St. Jude Children's Research Hospital in Memphis When Fozo and Quivey knocked out the gene in S. mutans, the bacteria's defenses fell; the cell membrane was no longer able to protect against ...

Biologists ID defense mechanism of leading fungal pathogen

...ptible to NO than other strains and it proved less virulent in mice than strains of Candida found in the wild. In addition to interfering with Candida's signaling process, Gustin's group is working with the research team of Rice biochemist John Olson. Olson, the Ralph and Dorothy Looney Professor of Biochemis...

Researchers recommend new approach to combat drug-resistant staph infections

...tion therapy. RIP prevents the bacteria from being virulent by inhibiting a target protein (TRAP). All rats in...nication would preclude the bacteria from becoming virulent and releasing large quantities of infection-causing toxins. The discovery of RIP has done that. "We ...

Inadequate vaccines can help breed more vicious malaria strains

...d create conditions which promote the evolution of virulent strains of malaria, according to a laboratory-base...nation can, in fact, lead to the evolution of more virulent strains of the disease. Initially, the Edinburgh researchers directly injected two groups of mice w...

TIGR president discusses significance of finding anthrax toxin

...evention (CDC), found the anthrax toxin genes in a virulent strain of the soil bacterium Bacillus cereus that was isolated from a patient who was suffering from a pneumonia similar to inhalation anthrax. It is not yet known exactly how the anthrax toxin genes ended up in the B. cereus isolate, but the process...

Vaccines against foodborne disease on horizon

... development of an edible vaccine against the most virulent forms of the Escherichia coli bacteria, known as shiga toxin-producing E. coli, which include the destructive E. coli O157:H7. These bacteria, because of the shiga toxin they produce, can cause mild to bloody diarrhea and in some cases are responsib...

Jay Levy honored with 2004 Abbott Laboratories Award in Clinical and Diagnostic Immunology

.... He and his group showed that HIV can become more virulent over time and can infect the brain, bowel, and several other tissues besides the immune system. Another early result of Levy's pioneering research was his development of a heat inactivation treatment that removed HIV from blood products and made rece...

Researchers say US military accidentally introduced tree pathogen to Italian estate

...ar trees. "Right now we know that this pathogen is virulent on Italian stone pines, but we don't yet know if it has affected other pines or broad-leaf species in Europe," said Gonthier. "When tourists visit the region, they expect to see these stone pines. It's the landmark tree for the Mediterranean coast. W...

Purdue scientists: To stop cancer, keep your Icmt away from your Ras

...half of all colon cancers and one-half of the most virulent lung cancers can be traced back to mutant Ras. "If you want to fight cancer, controlling Ras is an attractive approach," Gibbs said. "Since it requires a chain of modifications, researchers have long taken the approach that if you break the chain...

'Library on a Slide': Whole genome microarrays for comparative genomics

...idual strains. These differences can determine how virulent a particular strain is or which organisms it can colonise. To make significant claims about which genes play a role in which biological processes, researchers must compare large numbers of bacterial genomes and see which genes are associated with a p...

Researchers decode genome of rabbit fever pathogen

... that cause one strain of F. tularensis to be more virulent than another," said biologist Emilio Garcia, one o...8 hours after the disease is contracted. While the virulent SchuS4 strain sequenced by Uppsala University is found primarily in North America, the microbe seque...

Antibiotics may not be necessary when treating children with a simple skin abscess

...ic-resistant bacteria are often thought to be more virulent than their ancestors, said Dr. R. Doug Hardy, assistant professor of internal medicine and pediatrics and the study's senior author. Many physicians now have questions regarding how aggressively to treat these antibiotic-resistant bacteria. "We were...

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