Wistar-discovered antibody will help diagnose appendicitis
(PHILADELPHIA) - NeutroSpec, a new imaging agent approved by the Food and Drug Administration for detecting certain difficult-to-diagnose cases of appendicitis quickly and accurately, is based on a monoclonal antibody called SSEA1 discovered at The Wistar Institute. Developed further by Palatin Technologies Inc., located in Cranbury, NJ, with assistance from Thomas Jefferson University, also in P...2004 Wistar Institute Science Journalism Award winners announced
PHILADELPHIA The joint winners of the 2004 Wistar Institute Science Journalism Award are Sue Goetinck Ambrose, a science writer for The Dallas Morning News, and W. Wayt Gibbs, senior writer for Scientific American. The shared award and cash prize of $5,000 will be presented to the two journalists at a ceremony in Philadelphia on June 4.... ...The judges chose to honor the two journalists for the...Call for Entries: The 2004 Wistar Institute Science Journalism Award
Philadelphia, PA - The newly established Wistar Institute Science Journalism Award aims to honor the most insightful and enterprising reporting on the basic biomedical sciences in print, broadcast, or online journalism during the award year. Entries for the 2004 award must have appeared between January 1 and December 31, 2003, and the deadline for submitting entries is February 29, 2004. The winn...Wistar-developed antibody shows promise against brain tumors in Drexel trial
PHILADELPHIA - A new treatment procedure for high-grade cancers of the brain, one of the most aggressive and deadliest forms of cancer, has shown promise in extending the survival time of patients participating in a clinical trial conducted under the supervision of Luther W. Brady, M.D., the Hylda Cohn/American Cancer Society Professor of Clinical Oncology at Drexel University College of Medicine...Wistar study offers new support for a 'histone code' theory of gene regulation
PHILADELPHIA - A new study by researchers at The Wistar Institute provides important experimental data to support a novel theory of gene regulation. The theory holds that coordinated patterns of modifications to DNA-packaging proteins called histones may be a key factor in turning specific genes on or off. ... ...The proposed system of gene control has been termed a kind of "histone code" by one...Regeneration in the mammalian heart demonstrated by Wistar researchers
PHILADELPHIA - Mammalian heart tissue may be capable of regenerating itself after serious injury, according to a new study by researchers at The Wistar Institute. Experiments with a strain of laboratory mice known as MRL mice detailed their potent ability to renew damaged heart tissue with minimal scarring. A report on the findings will appear in the online edition of the Proceedings of the Natio...Wistar scientists add difficult-to-sequence stretches to human genome data
.Philadelphia - In a new study, researchers at The Wistar Institute report extending the working draft sequence of the human genome to reach most of the tips of human chromosomes, called telomeres. The telomeres and adjacent regions were not fully included in the working draft sequence announced last summer because they have unique properties that make them particularly difficult to isolate and...Wistar scientist receives award from National Cancer Institute
. .PHILADELPHIA-- Louise Showe, PhD, a scientist at The Wistar Institute, was awarded one of the National Cancer Institute's (NCI) first grants under a new program, "The Director's Challenge: Toward a Molecular Classification of Tumors." . .The purpose of the Director's Challenge grants is to challenge the scientific community to develop a more informative classification of tumors using modern...Director of Emory Vaccine Center to give Wistar Institute's 1999 Tadeusz J. Wiktor Memorial lecture
. Rafi Ahmed, PhD, Director and Professor,Emory Vaccine Center, Emory School of Medicine, Atlanta. . 1999 Tadeusz J. Wiktor Memorial Lecture, named for the former.head of The Wistar Institute's rabies unit who developed the .rabies vaccine used today. Dr. Ahmed's lecture is titled, "Immune.Memory to Viruses.". . Wednesday, November 3, 1999, 4:00 pm.. . . The Wistar Institute ....Wistar scientists find striking similarities between bacterial virus and human adenovirus
.Philadelphia--Scientists in the Wistar Institute laboratory of Roger M. Burnett,.PhD., working in collaboration with scientists from the Department of.Biosciences and Institute of Biotechnology at the University of Helsinki,.Finland, have determined that the bacterial virus, PRD1, is strikingly similar,.both biologically and architecturally, to adenovirus, a human virus commonly.used as a trans...Wistar Institute scientists find key piece in gene regulation puzzle
. Philadelphia-- For the first time, scientists working in The Wistar Institute.laboratory of Ronen Marmorstein, PhD, in collaboration with Shelley Berger, PhD,.have determined the three-dimensional structure of a key enzyme involved in gene.activation. In nature, this enzyme, which is called GCN5, functions to attach.acetyl groups to histone proteins that are bound to DNA to facilitate gene.a....Philadelphia -- Three Wistar Institute immunologists have been awarded grants to. support their development of vaccines against diseases that attack the mucous.membranes. Principal Investigator, Hildegund Ertl, MD, was awarded a grant by.the Mary L. Smith Charitable Lead Trust for her research on HIV-1 vaccines. .Anthony Wlazlo, PhD, and Dariusz Kowalczyk, MD, researchers in Dr. Ertl's.laborat...Wistar Institute To Host Regeneration Symposium (Updated Schedule)
.. . . ..... . . The Wistar Institute, Joseph N. Grossman, M.D., Auditorium. . . . . The Mitchell Ross Symposium on Anaplastic and Other High Risk Embryonal Tumors of Childhood . 8:45 a.m. Session I . Moderator: Dr. Jerry Garvin. Wake Forest University School of Medicine . 9:45 a.m. Session II . Moderator: Dr. Max J...Wistar Institute To Host Symposium On Regeneration In The 21st Century
. The Wistar Institute. . . Joseph N. Grossman,.M.D., Auditorium . Open to the Public, No Admission. . . .10:30 a.m. "Regenerative Biology: A Millennial Revolution" . David Stocum, Ph.D., . Department of Biology, . Indiana University- Purdue University at Indianapolis. .11:35 a.m. "Towards the Identification a...Wistar Scientists Define Mechanism Of Action Used By Potential Magic Bullet In Cancer Treatment
.Farnesyltransferase inhibitors (FTIs) are a relatively new class of nontoxic.chemotherapeutic drugs that have an ability to target mutated oncogenes while.bypassing normal cells; i.e., they may be the long sought-after magic bullet in.cancer treatment. . .In pre-clinical studies, FTIs have proven to control the growth of cancer cells.and promote tumor regression. Little has been known, howeve...Wistar Scientist Awarded Philadelphia Foundation Grant For Work In AIDS Research
.Philadelphia -- Luis Montaner, D.V.M., Ph.D., a scientist at The Wistar.Institute, has been awarded a two-year $79,000 grant from the Robert I. Jacobs.Fund of The Philadelphia Foundation to support his "HIV-1 Patient Partnership.for Basic Research" project. Announcement of the award was made by Lynette E..Campbell, Vice President for Programs at The Philadelphia Foundation.. .Dr. Montaner's pr....Philadelphia -- Hildegund C.J. Ertl, M.D., a scientist at The Wistar Institute,.has been awarded a two-year $30,000 grant from the Cancer Research Foundation of.America to continue her development of a vaccine against Human Papilloma.Virus-16 (HPV-16).. .HPV is a sexually transmitted virus. HPV-16 is one strain of the virus that can.lead to cervical cancer. Over 10,000 new cases of cervical c...Wistar Institute Professor Named First Koprowski Professor
.Philadelphia - The Wistar Institute Board of Managers recently approved the.appointment of Professor Giorgio Trinchieri, M.D., as Wistar's first Hilary.Koprowski Endowed Professor. .The Hilary Koprowski Endowed Professorship, which is the Institute's first, was.established jointly in 1998 through The Wistar Institute Science Trust Fund,.whose members include Christopher Koprowski, Kathleen Sc...Wistar Scientists Gain Information About Molecular Recognition
.Philadelphia -- A group of Wistar Institute scientists working in the structural.biology laboratory of Ronen Marmorstein, Ph.D., have identified a new mechanism.by which proteins regulate DNA transcription. . .Two articles, "Structure of a HAP1-DNA complex reveals dramatically asymmetric.DNA binding by a homodimeric protein" and "Structure of HAP1-18-DNA complex.suggests protein/DNA interactio...Wistar Scientists Locate Genes Involved In Mammalian Tissue Regeneration
.Philadelphia, PA, September 29, 1998 -- Five years ago, Wistar Institute.immunologist, Ellen Heber-Katz, Ph.D., and her Wistar research team identified a."healer" mouse capable of regenerating ear tissue. In a paper appearing today.in the Proceedings of the National Academy of Sciences, they reveal their latest.data on the genetics of the "healer" mouse. . .Though still at the basic research....PHILADELPHIA, Penn. -- Wistar scientist, David Kritchevsky, Ph.D., will speak tomorrow.at the 1998 Annual Summer Toxicology Forum in Aspen, Colorado on the.antiatherogenic effects of conjugated linoleic acid (CLA). . .Dr. Kritchevsky's research has shown that CLA, a fatty acid found predominantly.in whole milk, cheese and, to a lesser extent in beef, reduces atherosclerosis. .An early indicatio...Chern Memorial Award Presented To Wistar Institute Postdoctoral Fellow
.PHILADELPHIA, Penn. -- The Wistar Institute Training Committee has chosen Dr. Nickolai.Barlev, a postdoctoral fellow working in the Wistar laboratory of Shelley.Berger, Ph.D., to receive the 1998 Ching Jer Chern Memorial Award. The award is.given annually to the Wistar postdoctoral fellow who has published the best.scientific paper during the year. . Dr. Barlev came to Wistar in 1997, after wo...American Cancer Society Grant Extended For Wistar Study Of Molecular Changes Leading To Cancer
.Philadelphia -- Wistar scientist, George C. Prendergast, Ph.D., has been awarded.a one-year extension on an American Cancer Society grant supporting his.laboratory's research into the molecular changes that cause normal cells to.become cancerous.. .One aspect of Dr. Prenedergast's research focuses on a cancer-causing gene,.called Myc, which has the ability to induce malignant cell growth. Six...Wistar Scientist Awarded US Army Prostate Cancer Research Program Grant
.Philadelphia -- George C. Prendergast, Ph.D., a scientist in The Wistar.Institute's Molecular Genetics Program, has been awarded a $491,000 US Army.Prostate Cancer Research Program grant for research into a possible new.diagnostic and prognostic marker for prostate cancer.. .An intriguing set of data accumulated in Dr. Prendergast's laboratory suggests.that a new prostate cancer suppressor gene...Wistar Scientist Awarded American Cancer Society Grant For Research On Gene Therapy
.Philadelphia -- Frank J. Rauscher III, Ph.D., head of The Wistar Institute's.Molecular Genetics Program, has been awarded a $224,000 two-year grant from the.American Cancer Society. The funds will be used to support his research into.the genetic causes of alveolar rhabdomyosarcoma (ARMS), a highly malignant tumor.found most often in the skeletal muscles of children. . .Dr. Rauscher and his Wi...Wistar Research Yields Information About Colorectal Cancer Cell Invasion
Using an antigen in mice, called murine epithelial glycoprotein (mEGP), which is...genetically similar to the GA733 antigen in humans, scientists working in the...Wistar Institute laboratory of Dorothee Herlyn, D.V.M., are gaining valuable...information about the GA733 antigen's role in tumor growth and metastases. ...Their findings appear in the May 6 Journal of the National Cancer Institute. .....Wistar Scientists Identify New Tumor Suppressor Gene For Breast And Lung Cancer
.Philadelphia, PA, March 1, 1998 -- Scientists at The Wistar Institute, working.in collaboration with researchers from around the world, have identified a new.gene, called BAP1, associated with breast and lung cancer development. The.group's findings, which may have major implications for the treatment of breast.and lung cancers, appear in today's issue of Oncogene. . .BAP1, discovered in the W....Philadelphia -- Ellen Heber-Katz, Ph.D., a professor and immunologist at The Wistar Institute, has been invited to speak at the 165th national meeting of the American Association for the Advancement of Science (AAAS). Her presentation on The Genetics of Tissue Repair and Regeneration in Mice will be one of only seven.science topical lectures designed to highlight emerging and innovative resear...