Tag: "yale" at biology news

$7.5 Million grant to Yale researchers for role of viruses in cancer

New Haven, Conn. -- The to continue studies on the role of viruses and mutant cellular proteins in tumorigenic transformation of cells. ... ...This grant, "Program on the Molecular Basis of Viral and Cellular Transformation," is currently in its 31st year and is one of the largest and longest-running basic science grants at Yale. It coordinates studies to understand how vir...

Yale digital diagnostic technology is basis of new company, HistoRx Inc.

New Haven, Conn. -- HistoRx, Inc., a bioscience company offering novel digital technologies for in situ diagnostics developed at , has located its operations at 25 Science Park in New Haven.... ... Their technology, called AQUA (Automated Quantitative Analysis) enables researchers to localize and quantify proteins in tissue while maintaining spatial relationships -- a process that was previo...

Yale scientists visualize details of how hepatitis C unwinds RNA

New Haven, Conn. -- Research led by Anna Marie Pyle, professor of molecular biophysics and biochemistry at Yale University reveals how a protein from Hepatitis C (HCV) unwinds RNA, potentially allowing it to be copied. ...... The work published in the journal Nature focuses on an enzyme, helicase NS3, that unwinds the RNA virus for replication inside cells. NS3 is one member of an extensive fami...

Donaghue Women's Health Investigator Program awards grants to three at Yale

New Haven, Conn. The Ethel F. Donaghue Women's Health Investigator Program, administered by Women's Health Research at Yale, has granted its 2004 Program Awards to three Yale researchers. The program offers grants to full-time Yale affiliated investigators for new research on women's health and on the sex-specific factors in health and disease.... ...The awardees include Ronald S. Duman, profess...

Yale scientists decipher odor code

New Haven, Conn. Yale scientists, working with the fruit fly as a model, have discovered how odors are encoded by the olfactory system into the complex messages that are sent to the brain. The study, published in the June 25 issue of Cell, provides new insight into how animals sense and distinguish odors, a process that is essential to identifying food, mates and predators.... ...Graduate stude...

Yale researchers receive $4.5 million grant to study spinal cord repair

New Haven, Conn. -- Yale researchers Stephen G. Waxman, M.D. and Jeffery D. Kocsis have received a $4.5 million grant from the Veterans Administration Rehabilitation Research and Development Service to continue their internationally recognized research training program focused on restoration of function in spinal cord injury (SCI) and multiple sclerosis (MS). ... ...The renewed five-year grant t...

Yale researchers discover new potential asthma therapeutic targets related to parasites and insects

An unusual protein called acidic mammalian chitinase (AMCase), is markedly increased in mouse models of asthma, making it an important link in finding the pathways that lead to asthma, Yale researchers report in today's issue of Science. ......Asthma is a disease produced by chronic inflammation of the airways. The AMCase protein was not previously thought to be involved in asthma. It was known t...

Yale professor receives Johnson & Johnson Focused Giving award

New Haven, Conn. -- Sidney Altman, Sterling Professor of Molecular, Cellular and Developmental Biology at Yale University has been awarded a three-year, Focused Giving Grant by Johnson & Johnson to support his work on coordinated regulation of the protein subunits of RNase P in HeLa Cells.... ... Professor Altman received the Nobel Prize for chemistry in 1989 for his work on RNaseP de...

Yale scientists visualize molecular detail of RNA splicing complex

New Haven, Conn. Scientists in the department of molecular biophysics and biochemistry at Yale revealed the crystal structure of the first described enzymatic RNA - what it looks like and how it reacts - in the journal Nature. ......Scott Strobel, professor and principal investigator of the study and his research team at Yale, used X-ray crystallography to image the self-splicing group-I intron...

Annual Chemical Biology Symposium at Yale May 14, 2004

New Haven, Conn. The Yale Chemical Biology Symposium, Friday May 14, is a day-long event designed to highlight and applaud new developments in science at the interface of chemistry and biology. ...... The symposium will be held from 8:30 a.m. to 2:30 p.m. in Room 110, Sterling Chemistry Laboratory, 225 Prospect Street, New Haven, Connecticut....... The annual symposium began in 1998, fueled by...

Yale researchers shed light on B cells involvement in autoimmune diseases like lupus

Using genetically altered mice, Yale researchers have generated a clearer picture of the origins of B cells and their involvement in autoimmune diseases such as lupus, rheumatoid arthritis and diabetes....... Published in the September 20 issue of Science, the study, led by Mark Shlomchik, M.D., associate professor of laboratory medicine at Yale School of Medicine, looked at B cells' reactions to...

In groundbreaking research, Yale and Salk Institute scientists reveal the structure of a key component that makes cells move

Researchers at Yale and the Salk Institute have determined the structure of a set of proteins called the Arp2/3 complex that helps cells move, paving the way for understanding how cells find bacteria and protect against infections.... ..."This is a dream come true to see the structure of this important protein complex in such detail," said principal investigator Thomas Pollard, professor of molec...

Yale and University of Chicago researchers discover 40-foot crocodile fossil, possibly the largest known so far

The bones of a 40-foot crocodile that dined on dinosaurs and 12-foot-long fish have been discovered by researchers at Yale and at the University of Chicago in the Cretaceous rocks in Niger, Africa. ......The crocodile weighed about 16,000 pounds and is called Sarcosuchus imperator. It was first described about 30 years ago by a French team, which found a partial skull. Since that initial discove...

Yale researchers develop first microarray chip for complete analysis of proteins

Yale University researcher Michael Snyder and his colleagues have created the first microchip able to analyze virtually all yeast proteins, the chemicals that carry out the activities necessary for life. ...... The new protein chip holds promise for significant advances in the study of the function of proteins in other organisms beside yeast, including humans. "Most development occurs through th...

Yale researcher receives $1.3 million NIH grant to build Center of Excellence in Biomedical Computing

Perry Miller, M.D., professor of anesthesiology and director of Medical Informatics at Yale School of...Medicine, has received a $1.3 million grant as part of a new National Institutes of Health (NIH) initiative to support planning for Centers of Excellence in Biomedical Computing at several universities nationwide. ... ...This "pre-center" grant provides funds over three years to help prepare Ya...

Yale researchers develop new molecule that eradicates cancer by destroying tumor blood vessels

Researchers at Yale have developed a new molecule they call "icon" that targets blood vessels in tumors for destruction by the immune system without harming vessels in normal tissues. ... ..."Our study resulted in the eradication of injected tumors and also of other tumors in mice that had not been injected," said principal investigator Alan Garen, professor of molecular biophysics and biochemist...

Yale scientists receive $15 million grant for human genome research

The National Human Genome Research Institute (NHGRI) has awarded Yale scientists a five-year, $15-million grant for human genome research. ... ...The award is part of the NHGRI's new Centers of Excellence in Genomic Science (CEGS) program. The NHGRI awarded just...three grants this year. The other two were given to the University of Washington. ......"We are grateful to receive such generous sup...

T cells can halt development of skin cancer, Yale researchers find

In a study published in today's issue of Science, Yale researchers show that gamma-delta T cells, a special...kind of white blood cell found in the skin, are critical in the defense against skin cancer development. ... ...The Yale team, including colleagues at Guy's King's St. Thomas Medical College in London, also found that when T cells of the alpha-beta type are selectively reduced, tumor grow...

Yale researcher testifies in support of embryonic stem cell research

Yale researcher Diane Krause testified today before the Senate Appropriations Subcommittee urging Congress to continue federal funding for embryonic stem cell research.... ...Krause, associate professor of laboratory medicine and pathology at Yale School of Medicine, has done extensive research on adult stem cells. She recently discovered adult stem cells in bone marrow that can create new liver,...

New clinical program development fund awards $17.6 million in grants for Yale-New Haven Medical Center

.New research at Yale in cancer, brain disorders, cardiovascular disease, developmental disorders and.organ transplantation will be advanced with $17.6 million in grants from the New Clinical Program Development Fund (the.Fund). .The Fund is a joint initiative created by the Yale-New Haven Health System, Yale-New Haven Hospital and Yale University.School of Medicine to support the development a...

Yale physicists first to create a 'squeezed state' of atoms, which could lead to improved sensitivity ofnavigation systems used on planes and ships

.Yale physicists have created a "squeezed state" of atoms using Bose-Einstein condensate (BEC), a sample of rubidium atoms so cold that all of the atoms collapse into a single quantum state. . .The results of their study, published in a recent issue of Science, may lead to improvements in the field of precision measurement and could.improve navigational systems on planes and ships. . ."Our exper...

Isle Royale wolves fewer, but thriving

.Houghton, MIThere are fewer wolves on Isle Royale this year than last, but those that remain are experiencing the best of times, according to Dr. Rolf Peterson, a Michigan Tech wildlife biologist who has directed annual surveys of the predators for the National Park Service for the past 31 years.. Peterson said the just completed 2001 survey showed total wolf numbers had dropped to 19 from 2...

Yale researchers find all of the gene targets for a protein

.New Haven, Conn. Using new DNA chip technology, Yale researchers have identified virtually all of the gene targets of some key proteins, known as transcription factors.. .Transcription factors tell a cell whether it will be, for example, a muscle cell or a nerve cell. They determine the fate of a cell by "turning on" a particular assortment of genes within the cell and they can control cell pr...

Yale scientists give the Golgi apparatus its own identity, paving the way for more targeted cancer research

.Researchers at Yale have discovered that, contrary to previous beliefs, the Golgi apparatus is an organelle that exists independently of the larger endoplasmic reticulum and is a crucial component of cell division.. .Published in a recent issue of Nature, the discovery gives researchers a better understanding of the cell division process and of the processes present in the uncontrolled cell div...

Yale researchers solve structure of the ribosome: groundbreaking achievement 'like climbing Mount Everest'

. In a landmark achievement, Yale researchers have determined the atomic structure of the ribosome's large subunit, paving the way for more effective drugs to fight infection. . . The findings, published in two separate articles in this week's issue of the journal Science, were derived in Yale laboratories led by Thomas Steitz, the Eugene Higgins Professor of Molecular Biophysics and Biochemist...

Yale scientists identify genetic form of hypertension in pregnant women

.A Yale research team led by Richard P. Lifton, M.D., professor of genetics, medicine, and molecular biophysics and biochemistry, has identified the molecular cause of an inherited form of hypertension in pregnant women. . . "We investigated a family with unusually severe hypertension and David Geller, one of our team members, discovered a mutation in the mineralocorticoid receptor gene in this...

Yale study pinpoints how plants adjust to and grow in various lighting conditions

. Yale researchers have identified how plants adjust their growth patterns to adapt to various lighting environments, paving the way for development of bigger, stronger plants that are more tolerant to pests and pathogens-bacteria and fungus.. . "Our study is the first step in understanding the biochemical mechanism of this process in plants," said Xing-Wang Deng, associate professor and dire...

People with autism and Asperger Syndrome process faces as objects, Yale study of brain abnormalities finds

.Yale researchers have for the first time used functional MRI to study brain organization in persons with autism and Asperger Syndrome and found that they perceive faces as if they were objects.. "This may be a result of a lifelong disinterest in people, and a failure to develop normal expertise for faces," said Robert Schultz, the study's principal investigator and director of the Neuroimaging...

Alexion and Yale discover harmful complement activation in patients with acute coronary syndrome

NEW HAVEN, CONN, March 13, 2000 -- Scientists from Alexion Pharmaceuticals Inc. (Nasdaq: ALXN) and Yale University School of Medicine, both of New Haven, CT, today reported they have discovered that patients with acute coronary syndrome (ACS) have severe inflammation including significant production of injurious complement components in their coronary arteries. The report was made at the Scientif...

Yale researchers pinpoint possible causes of dizziness in the elderly/study suggests dizziness is a geriatric syndrome

. A Yale study of elderly people found that 24 percent complained of recurring dizziness and that factors such as anxiety, depression and heart disease might cause dizziness.. . "This kind of dizziness is common," said Mary Tinetti, M.D., professor of medicine and public health at Yale School of Medicine.."While it's believed that dizziness is a symptom of specific diseases, the condition might...

Isle Royale wolves doing well

.HOUGHTON, MIThe wolves of Isle Royale National Park are doing well and should continue to hold their own in the foreseeable future, according to a just completed survey of the island's wolf and moose populations.. Park Superintendent Douglas Barnard said the island's wolf packs added five pups to the total population during the past year, but one adult wolf was killed this winter, leaving the...

Link between taste and temperature focus of 'thermal taste,' a new discovery by Yale scientists

. Manipulating the tongue's temperature can result in the same salty, sweet or sour taste caused by sugars, acids or other chemicals, a Yale study finds, furthering understanding of the physiology of taste. . . "We've discovered that specific tastes can be produced by temperature stimulation, just as certain chemicals can evoke only certain taste qualities," said Barry G. Green, principal inves...

Yale yeast genome study could lead to further understanding of diseases like cancer

.In the largest genome project of its kind to date, Yale.scientists have succeeded in fully characterizing the function of the.yeast gene, furthering understanding of how human cells work. . ."While the human genome project so far has focused on the discovery of.new genes, our study has taken gene discovery to the next level by.figuring out how the genes work," said Michael Snyder, professor and...

Yale researchers may have solved mystery about why 'Lonesome George' refuses to mate

. New Haven, Conn. "Lonesome George," the only remaining male of a subspecies of the giant Galapagos tortoise, may be turning up his nose at potential mates on nearby islands because the females most closely related to him are on an island 200 miles away, say Yale researchers studying the tortoises.. . "The Darwin Research Station has been trying to mate him with females from islands closest to...

Yale and Alexion report advance in spinal cord repair

.NAGOYA, JAPAN, Oct. 25, 1999 -- Researchers from the Yale University School of.Medicine and Alexion Pharmaceuticals, Inc. (Nasdaq: ALXN) today reported that.transplanting genetically modified pig cells into surgically damaged spinal.cords of non-human primates can regenerate the myelin sheath around the injured.fragment of the spinal cord. Alexion believes that these results represent a.critic...

Yale cancer center study underscores fears of discrimination over genetic testing

.(NEW HAVEN) -- Fear of genetic discrimination often keeps those concerned they.may be at risk for developing hereditary cancer away from the genetic testing.that can -- in some cases -- save their lives. Concerns about discrimination,.privacy and confidentiality in insurance and employment have even led to state.and federal legislation to help protect these individuals.. .The same fears of ge...

As world population hits six billion, Yale experts provide insight into 21st century environmental challenges

.New Haven, Conn. -- On Tuesday, Oct. 12, the Earth's population is expected to.reach six billion and Yale population expert Fred Meyerson says that unless.action is taken, projected future population growth will lead to increased.pressure on scarce resources such as land and water. . ."The two most important environmental challenges in the next century are likely.to be climate change and the lo...

Breast cancer relapse rates appear higher in women who have cancer-causing gene, Yale study finds

.New Haven, Conn.-- Women with cancer-causing genes who choose lumpectomy and.radiation therapy appear to have an increased risk of getting a second tumor in.the treated breast five to 10 years after treatment, a Yale study finds.. .The results of this 14-year study, appearing in the Journal of Clinical.Oncology's October issue, suggest that breast cancer patients who carry either.the BRCA1 or B...

Yale scientists find evidence healthy animals detect and avoid sick animals

. New Haven, Conn. -- A new study by Yale scientists has found that animals.can recognize and stay away from other animals that may infect them with a.disease.. . Professor David Skelly said that research completed in his laboratory in.collaboration with Professor Joseph Kiesecker, who is now at Penn State.University, shows that healthy animals can distinguish the odors given off b...

Isle Royale Wolves Bounce Back

.HOUGHTON, MI--The wolves of Isle Royale National Park have surprised scientists.again by staging a dramatic comeback just when wildlife managers were worried.that the island park's most storied species might be headed for trouble.. .Several times during the past two decades biologists have felt that.canine parvovirus or a perceived genetic weakness resulting from inbreeding was.placing the wol...
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