UCSF scientist Joe Derisi named MaCarthur Fellow
...geneticist, received the honor. His studies on the yeast Saccharomyces cerevisiae yielded major insights into the fundamental aspects of cells. He was also a pioneer in pharmacogenetics -- the study of the way natural variations in individuals' genes affect their response to drugs. DeRisi, who des...Punching the timeclock of life
...sed on observations of programmed aging in baker's yeast by Longo and co-author Paola Fabrizio. Scientists use baker's yeast to study aging because the molecular pathway that regulates its longevity is similar to that in othe...New sequence involved in DNA replication timing may aid in cancer detection
...lls control replication timing. Studies in budding yeast ( Saccharomyces cerevisiae ) have suggested that, ...cation timing, Huberman and Yompakdee used fission yeast as a model organism because of its small size, rapid cell cycle, and convenient genetics. "Human bei...$2.7 million grant to support creation of virtual zebrafish atlas
..., zebrafish provide a closer model for humans than yeast or fruit flies, which are also commonly used for medical research. In the early 1990s, Cheng and his team became the first to develop the zebrafish as a medical research model to study the relationship between high rates of mutation and the developme...'Fossil genes' reveal how life sheds form and function
... the utilization of galactose, suggesting that the yeast experienced an ecological shift that somehow remov...eed, probing the genomes of three other species of yeast that are unable to metabolize galactose, the Wisconsin scientists found the genetic pathway almost c...Prion propagation: Avoiding the toxic oligomer
...sion from monomer to oligomer to plaque. Using the yeast prion protein Sup35 to study how amyloids form, Jo...of amyloid formation and prion propagation. Though yeast aren't susceptible to prion diseases, they do assume what scientists call the yeast prion state. Two...Amyloid fibers sprout one step at a time
...se of the stepwise assembly of amyloid fibers in a yeast prion protein. Their findings suggest that these s...ephalopathy (mad cow disease) and scrapie. In the yeast cells Weissman and his colleagues used as research models, however, the insoluble prion merely alter...Researchers identify the genome's controlling elements
...ow living organisms put their genes to work. Using yeast as a testing ground, researchers at Whitehead Inst...ols with new computational methods. Harbison took yeast cells and subjected them all to a dozen nutritional, chemical, and temperature environments. "We tri...Scientists discover proteins involved in spread of HIV-1 infection
...ses. Previously, scientists determined that the yeast version of TSG101, called Vps23p, binds to two other proteins, Vps28p and Vps37p, to form the E ndosomal S orting C omplex R equired for T ransport (ESCRT-I) which then participates in the protein sorting and packaging process. However, the ana...Highlights of American Chemical Society national meeting in Philadelphia, Aug. 22-26
... commercially that were tested in humans, selenium yeast appeared to be more bioavailable than sodium selenite. Organic selenium, such as is present in yeast, is also a much more powerful antioxidant than inorganic selenite, according to a test-tube model of heart disease. The presentation is part of a two...Prions act as stepping stones in evolution
...irector Susan Lindquist reported that a particular yeast protein called Sup35 somehow altered the metabolic...am discovered that these new phenotypes afford the yeast cell a survival advantage. "But we still didn't know the molecular mechanisms behind this," says Tr...Tobacco promising factory for biopharmaceuticals
...rowth hormone is inserted into the genetic code of yeast (gene recombination), then the corresponding protein expressed in the yeast is called recombinant human growth hormone. Zhang's research starts with introducing the genes of i...You are what you eat: New insight into autophagy
...r machinery of autophagy is largely conserved from yeast to mammals, the control of autophagy in multicellular animals is necessarily more complex than in yeast, as it is likely to be involved in functions other than the starvation response," writes Dr. Stenmark. Stenmark's group went on to show that that ...NHGRI adds 18 organisms to sequencing pipeline
...ea squirts, two roundworms, several fungi, baker's yeast and many prokaryotes (bacteria and archaea) including Escherichia coli . Additional organisms already in the NHGRI sequencing pipeline are: the macaque, the kangaroo, the cow, the gray short-tailed opossum, the red flour beetle, the flatworm Schimdt...Commercialization deal boosts hope for new sickle-cell drug
...ug approved in 1975 and long used to treat vaginal yeast infections, jock itch, and athlete's foot. A team led by Dr. Carlo Brugnara, director of the Hematology Laboratory at CHB, discovered in the early 1990s that clotrimazole also reduces sickling of red blood cells. In sickle cell disease, the bod...Study reveals surprising 'remodeling' property of gene regulation process
...k of gene expression to occur." The study used the yeast genome as an experimental model to determine if chromosomal remodeling actually occurred. "The yeast genome is very simple compared to the human genome, but yeast are quite responsive to their environm...U of T microbiologists achieve results with pattern recognition software
...n recognition software to discover the function of yeast genes essential to cell life knowledge that could...need to live. "Given the similarities between the yeast and human genomes, our work should promote advances in genomics research in both yeast and humans," ...Study identifies genetics of fat metabolism, red wine link
... and extend mammalian lifespan. Research done with yeast has shown that a gene called SIR2 tends to promote longevity, and that yeast cells die prematurely if this gene is deleted, Leid said. Previous studies have shown that resveratr...Study finds plant enzyme function changes with location in cell
...n double bonds, desaturating the fat. While using yeast cells to determine the functions of several newly ... of the enzymes appeared to operate differently in yeast than it did in the plants: It inserted a double bond in a different place along the fatty acid carbo...Purdue yeast makes ethanol from agricultural waste more effectively
WEST LAFAYETTE, Ind. - A strain of yeast developed at Purdue University more effectively ma...used as animal feed, and the first license for the yeast has been issued to the biotechnology company Iogen Corp. Purdue's genetically altered yeast allows a...