Tag: "abnormal" at biology news

ESHRE continues ban on human reproductive cloning

...problems, not least of which is the high chance of abnormal babies, even if abnormalities are not apparent at birth. "Just as important, there are ethical objections. The deliberate generation of clones could infringe upon the dignity and integrity of human individuals by increasing genetic determinism and re...

Injection prevents blinding blood vessel growth in mice

...ries. It's also believed that VEGF contributes to abnormal blood vessel growth from the choroid layer of the ...ert a strong therapeutic effect in the eye against abnormal blood vessel formation. No side effects were identified. Peter A. Campochiaro, M.D., senior study...

JCI table of contents, 16 June 2003

...******** The difference a carbohydrate makes The abnormal development of the bile ducts inside or outside the liver, of which an early symptom in newborns is jaundice, is known as biliary atresia. Using a reovirus-induced model of this condition in mice, researchers have revealed it is the ability of the vi...

Silent DNA architecture helps block cancer cell growth

...us and precancerous cells can detect that they are abnormal and kill themselves, or remain alive indefinitely but cease proliferating, through two intrinsic processes called programmed cell death and cellular senescence. One goal of cancer chemotherapy is to help stimulate these potent antitumor processes. Re...

Prematurity, infections most likely causes of brain damage among infants

...ding, eight had seizures, 13 had hydrocephalus (an abnormal increase in cerebrospinal fluid) and nine had periventricular leukomalacia (brain softening). Several infants had more than one complication. Moreover, only three of 52 newborns whose umbilical cord gasses were measured had evidence of acidity, a f...

Researchers discover possible diagnosis, treatment, vaccine for mad cow, prion diseases

.... Mammals can contract prion diseases by ingesting abnormal or infectious prions. From the digestive system, these prions make their way to the brain. When an abnormal prion comes in contact with a normal prion protein, it causes the protein to misfold, thus creating ...

With government nod, gene therapy pioneered at UNC is given to children with rare disorder

...ously acquired motor skills, feeding difficulties, abnormal muscle tone (floppiness or stiffness), poor head control and megalocephaly (abnormally enlarged head). Paralysis, blindness or hearing loss also may occur. There is no cure for Canavan disease or a standard course of treatment other than symptomatic ...

Equine cloning may shed light on human cancer causes

...rtain chemicals in the body affect both normal and abnormal cell activity." Calcium more importantly, the relationship between the amount of calcium within each cell and outside each cell is key. Members of the horse family have a lower amount of intracellular calcium than humans and a correspondingly slow...

Abnormal immune response may play major role in glaucoma, study says

...), are the first evidence of a direct link between abnormal inflammatory immune responses and any type of glau...ugh more rapid and intense) to that in humans, had abnormal immune responses in their eyes", says Streilein. Glaucoma is the second leading cause of blinding ey...

Hebrew University researcher wins prize for work leading to new anti-cancer drugs

...ins turn themselves off and what goes wrong in the abnormal Ras. Importantly, they were also able to demonstrate that normal enzymatic activity can be restored to mutant, oncogenic Ras A further stage of the work is now progressing for the design of chemical compounds to "rescue" mutant Ras proteins in vivo,...

National Jewish faculty to present research at American Thoracic Society

...M-infected patients seen at National Jewish had an abnormal gene for alpha-1 antitrypsin, a protein that helps protect the lungs. Only 4% of general population has that mutation. Mutation of both copies of the gene typically causes severe emphysema. Almost all of the RGM-infected patients had only one mutated...

Mutated protein combination tied to excessive sugar production

...curs in the gene producing FOXO1, it results in an abnormal FOXO1 protein that no longer is sensitive to insulin. Consequently, the switch fails and the liver overproduces glucose, which spills into the blood and can damage vital organs and nerves. In his previous Nature paper [Sept. 13, 2001] Spiegelman demo...

Researchers discover common cause for aging and age-related disease

...n the worm and prevent the harmful accumulation of abnormal proteins that cause a debilitating Huntington's-like disease. The finding appears to be the first evidence in an animal of a link between aging and age-related disease. The molecules, called "small heat-shock proteins," are known to assemble into com...

Ovarian tumor cell sensitivity then resistance - to chemotherapy linked to genetic abnormality

...NA in ovarian cells tends to snap and recombine in abnormal ways. This causes the cells to become cancerous, but it also makes them highly susceptible to cisplatin. "Cisplatin has been a front-line chemotherapy drug for ovarian and other cancers for decades," explains the study's first author, Toshiyasu Tani...

Johns Hopkins receives $24 million from Donald W. Reynolds Foundation to study sudden cardiac death

...ogical therapies, including stem cells, to prevent abnormal heart rhythms and sudden death in patients recovering from heart attack. They also will use modern imaging techniques to better define the functional, structural and metabolic features of the heart posing the greatest risk for life-threatening arrhy...

Genetic reconnaissance identifies new colon cancer genes

...lon cancers. Researchers have known for years that abnormal activity of tyrosine kinases can hasten the development of certain forms of cancer. In this first-of-a-kind survey, researchers used a forward-looking approach to screen the genes that produce tyrosine kinases -- reasoning that somewhere in this geno...

2003 ASM Communications Award goes to Milwaukee Journal Sentinel reporters

...nsin that also explored the complex science of the abnormal proteins called prions and the diseases, such as chronic wasting disease, they are believed to cause. The Award, given annually since 1996 to recognize outstanding achievement in increasing public awareness, knowledge, and understanding of microbiolo...

Schepens Eye Research Institute scientists at ARVO

...r Endothelial Growth Factor Trap, could block the abnormal growth of corneal blood and lymphatic vessels that accompany certain types of corneal diseases (in this case, inflammatory corneal diseases such as herpetic keratitis). Their study also demonstrated that this new drug might ultimately prevent the rap...

Gene enhances prefrontal function at a price

...iological phenomena associated with schizophrenia: abnormal prefrontal function and up-regulated striatal dopamine activity," suggest the researchers. Many mysteries still surround the COMT gene's possible role in schizophrenia and other psychiatric illness. For example, last Fall a team of researchers in I...

Hyperglycemia may increase risk of eye disorder in premature infants

...opathy of prematurity (ROP), a condition marked by abnormal blood vessel growth in the retina, and hyperglycemia, which occurs in about 45 percent of all infants weighing less than 2.2 lbs. The Johns Hopkins researchers found that infants with ROP had higher daily blood sugar levels compared to healthy inf...

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