Beware cancer, insomnia and liver disease UH students are taking aim
... could develop a way to control gene expression in abnormal cells, then we would be able to control the growth of tumors. To reach that point, we need to have a strong basic understanding of the process of gene expression." A third student and winner from NSM's Biology and Biochemistry department, Marisa R...Cell growth and death controlled by single pathway in lymphoma cancer model
...cause lymphoma is a tumor of the immune system and abnormal activation of the NF-kB pathway, which is normally...nvolved in setting up an immune response, leads to abnormal proliferation." But the scientists also discovered five genes they say are known to be involved in ...Fox Chase discovery may help physicians diagnose, treat devastating childhood disease
...ations at EDNRB have associated syndromes, such as abnormal pigmentation, with white spots in the skin and hair, and hearing loss. Defects in the EDNRB signaling pathway also play a part in other major diseases, including cancer, hypertension and cardiovascular disorders. Research elsewhere has shown that in...Clemson researcher receives Komen grant
...characterized by uncontrolled growth and spread of abnormal cells. If the spread is unabated, it can result in death. Cancer is caused by both external factors, such as radiation and chemicals, and internal factors, such as hormones, genetic mutations and immune conditions....UW-Madison scientists find a key to cell division
...d development of all organisms and, critically, of abnormal cell division, when the key proteins fail. These failures can lead to infertility, birth defects, cancer and neurological problems such as Huntington's and Alzheimer's diseases. "Going from one cell to two, or cytokinesis, is one of the most fundamen...Shortened chromosomes linked to early stages of cancer development
...testine, mouth and cervix, the research team found abnormal telomere lengths in 97 percent of the cases examin...cers," says Meeker. "It's a strong indicator that abnormal telomeres are likely playing a causal role in cancer development." Telomeres cap the chromosome ends...Genomic imprinting in disruptive spermatogenesis
...les is expressed. Imprinting disorders can lead to abnormal fetal development and malignant disease, and have ...mprinting defects in sperm. To investigate whether abnormal genomic imprinting could be associated with disturbed spermatogenesis, Professor Mario Sousa and col...... vitamin D is the best way for the body to control abnormal cell growth which could lead to: Improved bone health and prevention of osteoporosis, osteomalacia, and rickets Reduced risk of heart disease, stroke, and breast, colon , prostate and other cancers Alleviation of skin disorders Decreased risk of...Imaging study shows brain maturing
...archers. By contrast, children with autism show an abnormal back-to-front wave of gray matter increases, rather than decreases, suggesting "a specific faulty step in early development." Also participating in the new study were: Leslie Lusk, Cathy Vaituzis, Tom Nugent, David Herman, Drs. Deanna Greenstein, L...Gene discovered for Cornelia de Lange syndrome, a disabling genetic disease
...Nipped because a mutation in that gene produces an abnormal fly wing that looks like it had a small bite taken out of it, said Dr. Jackson. Both the fruit fly gene and the human gene regulate biological signals that have wide-ranging effects during development, on a variety of organ systems. This discovery is...JCI table of contents, 17 May 2004
...docytes from a3-integrindeficient mice, which have abnormal podocyte structures. They further observed induction of podocyte B7-1 expression in other models of nephrotic syndrome and found a correlation between podocyte B7-1 levels and the clinical severity of human lupus nephritis. Additionally, the absence ...Chromosome losses mean poor survival in childhood leukemia
...curs in 2 to 5 percent of children with ALL, is an abnormal chromosome that sometimes occurs in several types ...ses with a chromosome 22. The fusion results in an abnormal protein that plays an important role in the malignancy....Closing in on the cellular culprits of schizophrenia
...re we found that it is highly expressed and highly abnormal in schizophrenia."...Kinase backgrounder: Iressa discovery part of major kinase project at Dana-Farber
...gh their genetic blueprints for genes that produce abnormal growth-stimulating proteins known as tyrosine kina...ive type of infant leukemia. With this distinctive abnormal kinase, the disease warranted a new, specific name: mixed lineage leukemia. As with the case of CML ...Study identifies which patients can benefit from targeted lung cancer drug and why
...g for mutated genes that instruct cells to produce abnormal versions of growth proteins called tyrosine kinase...aveling to a science conference, seeks to identify abnormal tyrosine kinases enzymes that spark or halt growth in cancer cells and test agents known to act ag...Harvard Stem Cell Institute hosts inaugural symposia
...he brain; blood diseases, including leukemia where abnormal blood cells are produced, and immune system diseases such as AIDS; cardiovascular disease, where heart muscle tissue is destroyed during heart attacks; musculoskeletal diseases, such as muscular dystrophy. The Details to Date: Educational Web si...Sick Kids researchers look at viral triggers for multiple sclerosis in children
...uch as infections), genetic predisposition, and an abnormal autoimmune response. At least five per cent of all MS patients experience the onset of their disease before the age of 18. It is estimated that 50,000 Canadians have MS. Multiple sclerosis is the most prevalent in countries that are furthest from the...Biochemist becomes 15th UT Southwestern faculty member serving on National Academy of Sciences
...nts for cancer but also to therapies targeting the abnormal cells in neurological diseases, such as Alzheimers and Parkinsons. Originally from China, Dr. Wang received his undergraduate degree from Beijing Normal University before moving to the United States to pursue graduate studies at UT Southwestern, wher...Study is another step in determining if curry can protect against Alzheimer's
...hondrial metabolism can act as causative factor of abnormal function and cell death. Various toxins in the environment can injure mitochondrial enzymes, leading to increased generation of free radicals and oxidative stress, that over the life-span would eventually play a major role in aging. Free radical's ox...New research explores 'early bird' and 'night owl' sleep patterns
...nt in establishing the genomic basis of normal and abnormal variation in sleep patterns. Further research into the genetic basis of these differences may very well help dissect the multigenic and physiologic mechanistic pathways involved in circadian sleep and behavior in rats that would be homologous to thos...