Electron Accelerator Provides Unique Proof Of Gene Repair Process In Living Cells
...out blasting it away," said Petrini. "The electron accelerator at the Synchrotron, which generates so-called 'ultra-soft' X-rays that are extremely limited in their effect, allowed us to do that." To damage only a small area of the nucleus, the researchers irradiated the cells through a miniscule grid made of g...Pharmacologists Discover Linkage Of Key Cell Switches
.... Their finding, like discovering that the accelerator and brakes of a carare mounted together, represents an important basic insight into the machinerythat controls living cells. The discovery also offers the potential for a newstrategy for developing drugs that would manipulate one or both of the linke...Hopkins Researchers Discover Key Target In Molecular Pathway That Initiates Colon Cancer
... that mark cancers. "Cancer is like a car with the accelerator pushed to the floor and failingbrakes," says Vogel...and a Hughes scholar. "In this case, c-MYC is the accelerator and APC is the failed brakes," heexplains. When suppressor genes, like APC, malfunction either thro...Scientists document most recent date for Neandertals
...t have been small and rather subtle." Using direct accelerator mass spectrometry radiocarbon dating, team member PaulPettitt and colleagues at Oxford University (England), determined that twopieces of Neandertal skulls from the Vindija cave site are between 28,000 and29,000 years old. The new Croatian dates refu...Neurosteroids: the missing link?
.... "These are glutamate and GABA. Glutamate is the accelerator pedal and GABA is the brake pedal. GABA essentially shuts the brainoff." Morrisett explained that neurochemists and electrophysiologists were at odds for almost 20years because one group believed that alcohol strongly activated GABA function while ...Purdue center to lead national research in dietary supplements
...of-a-kind rare isotope laboratory. The PRIME Lab's accelerator mass spectrometer will allow researchers to monitor bone loss in 50 days that otherwise would take two to four years, Weaver said. "For our osteoporosis study, for example, we'll be able to use just nine people and test them for seven different produ...Five Rutgers professors named fellows of national science association
...ing experiments at national and university nuclear accelerator facilities in the United States and abroad. She is the graduate program director in physics and astronomy, and this year is teaching the seminar in physics course, required of all first-year graduate students. Joan G. Ehrenfeld, professor in the de...Lawrence Livermore Lab, UC Davis Cancer Center ink alliance to develop integrated cancer program
...s. * Ultrasensitive pharmacokinetic studies using accelerator mass spectroscopy that analyze how well drugs are absorbed in the body. This study shows promise in helping physicians to fine-tune chemotherapy dosages based on an individual's metabolism, lessening toxicity and improving chemotherapy effectiveness....Pooling worldwide data about childhood tumors helps researchers gauge aggressiveness of treatment
... a cancer-causing "oncogene." Often compared to an accelerator pedal, MYCN can cause cancer cells to multiply in a runaway fashion. When MYCN is amplified -- which means that cells have 200 copies rather than the normal two copies of the defective gene -- the prognosis is grave. In fact, at the time of Hunters d...Researchers explain how protein inhibits angiogenesis
...s. This integrin molecule normally functions as an accelerator of angiogenesis, explains Kalluri. But when tumstatin connects with integrin, it brakes the acceleration and, by exerting a negative force, stops the production of proteins. As a result, the endothelial cells die, angiogenesis is halted, and the spre...The role of obesity and calories in cancer prevention
...expression of Wnt-1 (an oncogene that acts like an accelerator to enhance cell proliferation). Female p53-deficient Wnt-1 transgenic mice provided with unlimited access to food became obese and rapidly developed fatal mammary tumors, while miceprovided with fewer calories each day, or fasted one day per week, l...Clemson researcher takes part in breakthrough research on insects
...roblem by using a synchrotron, a circular particle accelerator that can generate x-rays. The one at Argonne National Laboratory ranks among the most powerful in the world. "This is the first time anyone has applied this technology to create x-ray videos of living animals," says co-author Wah-Keat Lee, a physicis...Fruit flies unlock Methuselah's secrets
...ly controlled transposable element that acts as an accelerator of gene expression to find mutations that could make flies live longer. Crucially, they were able to turn this acceleration on an off by feeding the flies a specific chemical and to look at the effects of the mutations in adult flies. Their experime...DFG to establish nine new collaborative research centres
...ical University of Darmstadt. The Darmstadt linear accelerator is unique in its kind and makes it possible, in particular, to examine electrical and magnetic nuclear stimulus at low energy levels and with impulse transmitters. This means that it is possible to carry out experiments which address fundamental ques...Chemists unlock secret to activating tumor suppressor gene
... cell goes out of control. It's like a car with an accelerator but without the brakes." It was generally thought that PTEN was activated by binding to other proteins, giving it a signal to interact with the cell membrane. But Cho said that's not the case. Cho's group found that PTEN itself can be activated by ...UCLA receives NSF award for plasma research
..., unlimited renewable energy source. New particle accelerator technology, to reduce the current kilometer size of atom smashers to meter lengths and for developing compact accelerators used in medical treatments. Space weather, to understand the near-earth plasma environment to guarantee the reliability and pe...Moving the target for osteoporosis treatment
...em always has one foot on the brake and one on the accelerator at the same time because bone is a very key tissue and you want it to be very tightly controlled," Dr. Isales said. Before findings such as those at MCG began emerging, it was believed bone regulation was an endocrine function, that ACTH and other ...New NASA facility will help protect space crews from radiation
...internal organs," he said. For each experiment, an accelerator produces beams of protons or heavy ions. These ions are typical of those accelerated in cosmic sources and by the sun. The beams of ions move through a 328-foot transport tunnel to the 400-square-foot, shielded target hall. There, they hit the target...'Elves' makes protein crystallography easier
...ographic studies of proteins. The ALS - a particle accelerator called a synchrotron because it produces X-ray synchrotron radiation - upgraded in 2001 to become a cutting-edge source of high-energy or "hard" X-rays ideal for protein crystallography. At present, the ALS has six hard X-ray beamlines dedicated to X...Dazzling new light source opens at Stanford Synchrotron Radiation Laboratory
...nal Institutes of Health have joined in funding an accelerator research facility. I expect this to be a long and ...uccessful. In a remarkable accomplishment, the old accelerator was dismantled, a new tunnel floor poured, SPEAR3 installed and commissioned, and users back online-...