UT Southwestern Nobelists find protein structure that may help fight high cholesterol
...releases its LDL in cellular compartments that are acidic and then returns to the plasma membrane, where it is "recycled." The LDL receptor's extracellular domain consists of two major parts, the LDL binding region and the so-called "beta-propeller" region. In the Science study, the structure reveals that p...Tips from the Journals of the American Society for Microbiology
...pH conditions. While all four inhibited growth in acidic conditions, only two were able to inhibit growth under neutral pH. The researchers believe that the lactobacilli were able to inhibit growth by producing hydrogen peroxide. "On the basis of these data, one might hypothesize that the capacity of com...JCI table of contents, January 15 2003
...diated hepatocellular apoptosis andliver damage in acidic sphingomyelinase knockout mice TNF-alpha induces ...F-alpha by twosphingomyelinases, neutral SMase and acidic SMase (ASMase), is apro-apoptotic signaling intermediate. Having found that ASMase-deficientmice are...Researcher explores tumors' survival strategy
...ation," Dr. Motamed said. SPARC - secreted protein acidic and rich in cysteine - is commonly expressed in the healthy remodeling of tissue, such as during embryonic development and wound- healing. It also is expressed in varying degrees by different cancers; expression is increased in breast cancer, prostat...15-foot hypodermic needles provide evidence for vast oceanic crustal biosphere
... for 20 years of microorganisms that thrive in the acidic iron-, sulfur- and heavy-metal-rich fluid environments in areas where seafloor is being created at mid-ocean ridge spreading centers. These areas are subject to frequent volcanic eruptions and can have fields of hydrothermal vents that pour superheat...Water quality in Adirondack lakes responding to acid rain regulations
...cies than Brook Trout, so certain lakes may be too acidic for one but not the other. The goal is to get ANC up to a level where the water can support a diverse biological community. An ANC of about 200 microequivalents per liter is considered highly positive. The good news is that ANC is increasing in many ...Microgel polymer beads may provide general vehicle for vaccines, gene therapy
... merge with acid-filled lysosomes to become highly acidic digestive chambers.) Making the beads is a bit li...f the protein is released in about six hours under acidic conditions typical of the phagosome. In nearly neutral conditions characteristic of blood, only 10 p...Bacteria convert food processing waste to hydrogen
..." says Van Ginkel. Keeping the wastewater slightly acidic in the hydrogen production step helps to prevent any methane-producing bacteria from growing and consuming hydrogen. After only a day of fermentation in oxygen-free or anaerobic conditions, the hydrogen-producing bacteria fill the headspace in the f...'Kiss-and-run' rules the inner lives of neurons
...ped by other researchers, does not fluoresce under acidic conditions normally present in vesicles fully load...le releases its payload, the interior becomes less acidic and the vesicle glows a bright green. Thus, said Stevens, by imaging individual vesicles in cell cul...Organelle's discovery challenges theory, could alter approach to disease treatment
... transport. He named it an acidocalcisome for its acidic and calcium components. In 2000, he reported its ...s membrane, which is used to maintain its interior acidic content. This has never been described before in a bacterium." The existence of discrete organelles......in protein complexes containing subunits with long acidic tails. The so-called SET complex (containing the SET component) is cleaved at multiple sites and dismantled during killer cell attack. A cellular Mg2+-dependent DNase, called NM23-H1, is thereby freed from this complex and degrades the DNA nucleus by...New research challenges prevailing theory of microbial biodiversity
...discovered in the 1970s - and can withstand highly acidic conditions and temperatures as high as 180 degrees... specifically adapted to life in the extremely hot acidic environments of a geothermal hot spring," said Whitaker. "It's not too surprising that geographicall...Stay-at-home microbes: New study finds micro-organisms more complicated than we thought
A study of microbes that thrive in hot, acidic conditions has overturned a long-held view that sp...thor, focused on the archaeon Sulfolobus, found in acidic hot springs and flourishing at temperatures from 140-180 degrees Fahrenheit. She drew the vast major...UVa scientists detail salmonella protein
... large patch that may help SipA bind to the mostly acidic surface of actin....Clay may have aided formation of primordial cells
...re stable at basic conditions, are exposed to more acidic conditions, they spontaneously assemble into vesic...s to which micelles had been added -- finding that acidic conditions induced the micelles to become unstable and somehow incorporate themselves into a growing...Study of primitive life form expected to provide clues to biological processes in higher organisms
...ch, is studying a primitive organism discovered in acidic hot springs at Yellowstone National Park to find clues about that mechanism in higher organisms. A $400,000 grant from the National Science Foundation is allowing Kennelly to continue his investigations into the process of protein phosphorylation. T...JCI table of contents, January 2, 2004
...ate is reduced to nitrite by oral bacteria. In the acidic environment of the stomach, nitrite is further reduced to nitric oxide, which has broad biological activity. In the January 2 issue of the Journal of Clinical Investigation, Jon Lundberg and colleagues from the Karolinska Institute in Sweden tested t...Microbial biofilm yields community genomes, metabolic clues
...am found its biofilm atopa hot, flowing, extremely acidic solution-laden withdissolved iron, copper, zinc an...er nearly a century ofoperations, created the most acidic mine drainage in theworld, discharging-on average-a ton of toxic metals everyday into the Upper Sacr...Scientists report first sequencing of environmental genome
...ke scum on the surface of green pools of water, as acidic as battery acid, in the dark depths of the Richmon...gen fixation, or their scavenging of iron from the acidic groundwater? "The next step in this project is to get whole community genome arrays up and running t......itions, such as low or high temperatures, basic or acidic environments or organic solvents." Horswill and Stephen J. Benkovic, the University professor, the Evan Pugh Professor of Chemistry and holder of the Eberly Chair in Chemistry, used enzymes from Escherichia coli and Bacillus subtilis, two common bac...