Other Highlights in the June 2 JNCI
...ethesda, Md., and colleagues show how estrogen may act as an angiogenic switch and allow progression of breast carcinoma. Contact: Susan Johnson, National Institute of Dental and Craniofacial Research, National Institutes of Health, 301-496-4260, johnsonS@od31.nidr.nih.gov Zoledronic Acid Treatment Be...'Noisy' genes can have big impact
...omoters we studied, a major source of noise is the act of preparing the promoter DNA, the regulatory regi...it. "And the step that is generating noise is this act of removing the nucleosomes, in order to allow access of the transcription machinery and the regulat...Molecular image of genotoxin reveals how bacteria damage human DNA
...where bacteria seek to make a home. "CDT may also act as an immunosuppressant," says Stebbins, "since the immune system requires cell division to respond to microbial infection." There are nearly 10 different species of disease-causing bacteria that use CDT, including Salmonella typhi, a bacteria that c...51 globally threatened species get new lease on life in the Caucasus
... groups from the six countries. The Programme will act as the hub of CEPF strategy implementation in the ... assist in reviewing grant proposals as needed and act as a technical advisory group, as well as assisting the new Regional Council in its overarching role...Stuart Lipton honored with Jung Prize for Medicine
...nder "normal" conditions. Conventional treatments act by blocking the signals completely, which also blocks their intended function. Dr. Lipton discovered ways to control the gatekeeper receptor, NMDA, and moderate the activity through these pathways. The prototype treatment based on Dr. Lipton's co...Increasing ozone over the Atlantic ocean
...stion of fossil fuels and also by biomass burning, act as catalysts of ozone formation. In turn, this reduces air quality and impairs human health, agricultural crops and natural ecosystems. Furthermore, ozone is a greenhouse gas, so that its increasing concentration in the troposphere contributes to cli...Bird's eye views earth's magnetic lines
...al magnetite, synthesized by living systems, which act like miniature compass needles. The new experiments reported in the May 13 issue of Nature took advantage of the fact that migratory birds held in "orientation cages" during their normal seasonal migrations use the magnetic field as a source of co...Dartmouth Medical School awarded $9 million grant for genomics research
...ring, through their work on Neurospora, that genes act by regulating chemical events. Since then, the Neurospora genome has been fully sequenced and is predicted to have 10,082 proteins, but it has not been the subject of intense analysis of this magnitude until now. The five-year grant among the inst...Study examines future of species extinction, conservation
...al species start to disappear, two forces begin to act upon a community, making it either more or less tolerant to the environmental condition. One of these forces occurs when species disappear in order of their sensitivity to a particular environmental factor, with the least tolerant ones going extinct...Pearly mussels: One of North America's natural jewels is disappearing
...correct fish species. In adulthood, pearly mussels act as filter feeders, eating plankton and other small particles of food suspended in the water. Long-lived animals, most species live for decades. Currently, little is known about either mussel diets or the fascinating relationship between larvae and t...Fat fighting undermined by over active eating pacemaker
...k team have identified very specific neurons that act as feeding "pacemakers". This specific group of neurons- which they have dubbed the "ARC pacemaker" produce regular bursts of electrical activity. However these cells integrate and process a wide variety of signals indicating the energy needs of t...Mimicking humpback whale flippers may improve airplane wing design
...mic design. The expanded hammerhead shark head may act like a wing. The trick now is to figure out how to incorporate the advantage of the tubercle flipper into manmade designs, said Fish. The research team now plans to perform a systematic engineering investigation of the role of scalloped leading edge...Closing in on treatment for Charcot-Marie-Tooth disease?
...MT. In stress situations, cells produce HSPs that act as 'chaperones', stabilizing other proteins and protecting against degradation. The specific function of the two HSPs in our peripheral nerves has not yet become clear, but the mutations that have been discovered in several European families are now...Archaeologists announce discoveries at the ancient Maya site of Waka' in northern Guatemala
...t of the building. "This kind of termination is an act of desecration and speaks to a violent event in the site's history," Freidel says. Excavations have also delved into the activity at residential compounds, and at the main palace complex of the site, where at one time the rulers of Waka' presided ove...Plankton may influence climate change says UCSB scientist
...reaks down into a variety of sulfur compounds that act as cloud-condensing nuclei, leading to increased cloudiness. With more clouds, less sunlight reaches the Earth and the biological processes which produce DMS are reduced. According to their research, it appears that phytoplankton produce organic sul...Other highlights in the May 5 JNCI
...in Boston, writes, "DNAzymes targeting c-Jun could act as both direct and indirect inhibitors of angiogenesis." Contact: Levon M. Khachigian, Centre for Vascular Research, The University of New South Wales, 61-29-385-2537, l.khachigian@unsw.edu.au Examining the Potential Conflicts of Interest of Clini...Kinase backgrounder: Iressa discovery part of major kinase project at Dana-Farber
...he body to make it grow and function. Many kinases act as on-off switches inside cells, controlling the continuous flow of chemical signals that tell the cell what to do. A kinase sends a "go" message by adding a chemical unit called a phosphate to another protein, changing its shape or altering its func...Campbell wins 2004 Abbott-ASM Lifetime Achievement Award
...ts' understanding of such questions as how viruses act as agents of evolution for host genomes and the interaction between bacteriophage evolution and population structure. As well as his formidable body of research, Campbell is also noted for his extraordinary commitment to the profession of microbi...Campbell to receive American Society for Microbiology lifetime achievement award
...ts' understanding of such questions as how viruses act as agents of evolution for host genomes and the interaction between bacteriophage evolution and population structure." Campbell also is being recognized for his "extraordinary commitment" to the profession of microbiology as author, educator a...Study identifies which patients can benefit from targeted lung cancer drug and why
...t growth in cancer cells and test agents known to act against them. "The focus on kinases grew out of the idea that they may offer a way to have an immediate impact on cancer," remarks Sellers, who is also on the faculty at the Broad Institute and HMS. "This study demonstrates that rational drug design...