Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis
...f brain cells the NPAS1 and NPAS3 proteins are acting upon. Information about this particular chemical pathway could provide further clues to a genetic link with human psychosis....The future of HIV therapeutics is brightening, according to Gladstone Institutes Director
...th new antiviral drugs. Combinations of inhibitors acting at each of the three steps in the viral entry sequence could soon form a new "triple cocktail" therapy for HIV-infected patients. Prospects in the longer term are also bright, with the recent discovery of natural antiviral factors that are very activ...Streptococcus infects humans by thwarting blood clotting
...ic mice to dissolve blood clots just as if it were acting on a human clot. "The critical experiment, though, was when Hongmin infected the skin of these transgenic mice with the group A streptococcus bacteria," said Ginsburg. "She found that the bacteria were much, much more toxic to these mice than the no...Circadian clock genes reign in duration of fruit fly copulation
...n--for example, by influencing male development or acting as components of a molecular timer....Why your knees and quads hurt more after running than walking: You're only human
... run), they found that limb muscles were primarily acting to generate force on the ground and the muscle's role in overcoming inertia and gravity was minimal. Results of the research are reported in a paper entitled "Muscle mechanical advantage of human walking and running: implications for energy cost," wh...Nucleic acid-amplification testing further safeguards nation's blood supply
...mproved testing," said Barbara Alving, M.D., NHLBI acting director. "NAT enhances the safety of the nation?s blood supply by further reducing these risks." The study is the first and only one of its scope to show the effectiveness of the NAT assay system nationally. All major blood donation laboratori...Scientists visualise cellular handmaiden that restores shape to proteins
...to back, and a 'cap' unit that sits atop the cage, acting as a stopper. The cage contains the unwound, or denatured, protein, while the chaperonin goes about refolding its shape using the cellular energy source, ATP. The structure of the chaperonin complex is one of the largest and most difficult solved by ...Technology already exists to stabilize global warming
...ase may be," Pacala continued. "The alternative to acting now is to watch the experiment happen and then find out how accurate we were." A strong case for action comes from three lines of evidence, said Pacala. First, investigations of the Earth's climate over the last million years show that vario...Biologists deciphering complex lemur scent language
... a specific function in terms of message, or is it acting as sort of a fixative for the more volatile components of the wrist gland?" Also, said Drea, there are indications that the same scenting behavior might have a different meaning at a different time. For example, male tail-waving might be used not jus...Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
...accine development," said George V. Ludwig, Ph.D., acting science director for USAMRIID. "In the past, our reliance on using natural proteins and other immunogens limited our ability to make useable and producible vaccines. New techniques such as those described offer nearly unlimited possibilities." ...New framework for biodiversity conservation
...phasizes the importance of being opportunistic and acting fast. "This approach would allow conservation agencies to move quickly and effectively to protect habitat," says Possingham. "Redirecting funds could help managers offer financial or other incentives to land owners, helping turn years of planning int...Workforce achievements celebrated at NASA Marshall Center Awards ceremony
...ight Projects Directorate; Joseph L. Randolph Jr., acting group lead for the Gravity Probe B Systems Engineering Office in the Science Directorate; Michael U. Rudolphi, manager of the Space Shuttle Propulsion Office; and Dennis A. Kross, former director of Marshall's Space Transportation Directorate and cur...HIV reveals evolution of a primate defense against intragenomic infiltrators
...mate evolution suggests that another force is also acting on the gene. Sawyer et al. propose that this force is exerted by human endogenous retroviruses, which act in many ways like foreign retroviruses. These mobile genetic elements emanating from one's own genome pose less of an immediate threat than a r...Anxiety during pregnancy affects child behavior
...ceptibility for attention deficits, hyperactivity, acting out and anxiety disorders in childhood. We also wanted to learn whether there are specific vulnerable periods during the pregnancy in which this anxiety "programs" the child's biological system, thus increasing the fetus' susceptibility for such diso......cinnamon oil might also affect adult mosquitoes by acting as a repellant," Chang says. The researchers havent yet tested this theory, but they plan to find out in the near future. The Council of Agriculture of the Executive Yuan, a government agency in Taiwan, provided support for this research. Jason Gor...Leading scientists design new framework for biodiversity conservation
...phasizes the importance of being opportunistic and acting fast. "This approach would allow conservation agencies to move quickly and effectively to protect habitat," says Possingham. "Redirecting funds could help managers offer financial or other incentives to land owners, helping turn years of planning in...Funding to commercialize technologies of UC San Diego engineers tops $1.2 million
...l and temporal distribution of mechanical stresses acting on the vessel walls, the project could lead to a quantitative assessment of the risk of rupture in AAA - and potentially provide improved guidelines for intervention. Lasheras will work with other engineers, computer scientists as well as physicians ...Report outlines steps needed to lessen smallpox threat
...of experience with commissioning such products and acting as the sole market for them," said Harrison. "But the federal health agencies do not, so we recognized that such arrangements would require significant changes in how they interact with industry." The report emphasized that there is a basic lack of k...Researchers discover how worms' noses sense oxygen
...nzyme, they were able to show that this enzyme was acting as an oxygen detector, primarily steering worms away from too much oxygen. The enzyme is found in three separate neurons that innervate the worm's nose. Bargmann speculates that the oxygen-sensing system used by C. elegans may be used by other animal...New compound 'highly efficacious' at reducing human tumour growth
...ficacious at inhibiting tumour growth and works by acting on two separate mechanisms that are involved in the development and perpetuation of human cancer cells", said Dr. Siemeister. The compound has already entered phase I clinical trials to determine tolerability and pharmacokinetics in humans and to est...