JCI table of contents, 15 March 2004
...or peptide associated with the autoreactive T cell acting as an ergotope that induces anti-ergotypic T cells that in turn affect the autoreactive T cells. In the March 15 issue of the Journal of Clinical Investigation, Irum Cohen and colleagues, from The Weizmann Institute of Science, Rehovot, Israel, prov...Rimonbant shows promise in addressing multiple risk factors
...pact the way our bodies regulate energy balance by acting in the brain and on fat cells throughout the body," says Dr. Despres. "This suggests the importance of the Endocannabinoid System that we are only beginning to understand. The promise of rimonabant is that it may provide an entirely new therapeuti...Baker's yeast rises from genome duplication
...able to evolve more rapidly with natural selection acting on thousands of duplicated genes simultaneously, allowing for large-scale adaptation to new environments. This super-organism doesn't come without drawbacks. The excess genes cause instability in the genome and are deleted through mutation, gene loss...JCI table of contents, March 1 2004
...5.pdf ACCOMPANYING COMMENTARY: CD1a and langerin: acting as more than Langerhans cell markers AUTHOR CONTACT: Akira Takashima University of Texas Southwestern Medical Center, Dallas, Texas, USA. Phone: 214-648-3419 Fax: 214-648-3472 E-mail: akira.takashima@utsouthwestern.edu View the PDF of this comment...Lake restrictions make lakeshore property more valuable
...act to ecological change, as they are players both acting and being acted upon by their environment. "We want to be able to understand the causes of long-term changes observed in ecological systems, and we want to develop effective mitigation or management strategies," says Kratz. "We will have little chanc...Dirty air from Asia can push U.S. air pollution to unhealthy levels
...utian Islands and a high-pressure cell near Hawaii acting like twin gears that propel the air mass. Various forces over the Pacific can affect the altitude at which the pollution enters North America, but eventually it drops low enough, between ground level and 3,500 feet, to have an impact on air quality. ...Data shows FUZEON does not increase lipodystrophy in pre-treated HIV patients
...r, FUZEON works before the other classes of drugs, acting outside the immune cell and blocking the virus before it can enter. Based on the results presented at CROI, Roche is exploring clinical research to assess the benefits of adding FUZEON to nucleoside sparing regimens designed to decrease toxicities as...Substances found in blood may predict development of preeclampsia
...lt-1) binds to VEGF and PlGF, preventing them from acting on the cells that line the inside of blood vessels. Pregnant women who carry normal pregnancies to term also have sFlt-1 in their blood. In these women, however, sFlt-1 is present at much lower levels, and much later in the pregnancy-- shortly befo...Making new muscle: Researchers in Rome produce a mouse that can regenerate its tissues
...at bore a distinctive, fluorescent tag. "mIGF-1 is acting like a megaphone," Musar says. "If there's an injury, muscles expressing mIGF-1 send out a very loud signal, and stem cells respond from quite far away. After birth, most animals lose the signal, which may be one of the key reasons that our tissues d...Molecular level discovery could play role in development of new antibiotics
...hey tried to manipulate a peptide substrate. LctM, acting in the presence of adenosine triphosphate and ionized magnesium, selected specific serines and threonines for modification, allowing for a correct final structure of the material. It was reported in 1999 that lantibiotics such as nisin are effective ...Sex in the brain: How do male monkeys evaluate mates?
...even in monogamous species aren't necessarily just acting on some primal urge to procreate, without a second thought. Rather, they exhibit highly organized, complex neural processes. "This is the first time anyone has imaged an awake nonhuman primate in response to emotionally arousing stimuli; it is also t...A killer microbe as a living antibiotic
...-old prey-predator relationship. The lytic enzymes acting on cellular systems that are not targeted by conventional chemical antibiotics are thereby especially interesting. Far reaching anti-microbial strategies aim at using Bdellovibrio as a "living antibiotic". This seems feasible, as Bdellovibrio is n...New advance to combat antibiotic-resistant pneumonia and malaria
...by developing mutations that prevent the drug from acting on the bc1 complex. "We were able to isolate the genetic mutations that enable the pathogens to resist the drug when it is introduced to our yeast samples," said Dr. Bernard Trumpower, professor of biochemistry at DMS and corresponding author of the...Understanding urinary tract infections
...o processing of environmental cues, and instead of acting like individual bacteria, they behave more in a multicellular manner, working together to defeat the cell's defenses." Hultgren and his coauthors divided E. coli's infectious process into four stages. In the first, bacteria enter bladder cells and be...Climate change may threaten more than one million species with extinction
...n dioxide, methane, and nitrous oxide traps heat, acting much like a greenhouse in the atmosphere....Separation day arrives for Mars Express and Beagle 2
...lly targeted at its destination. With Mars Express acting as a champion darts player aiming at a bullseye, Beagle 2 should be placed on a collision course with the planet, following a precise ballistic path that will enable it to hit a specific point at the top of the Martian atmosphere in six days' time. ...Chimp vs. human DNA: what's in the 1% difference
... came from a particularly strong sign of selection acting on the gene that codes for an obscure protein in the tectorial membrane of the inner ear. One form of congenital deafness in humans is caused by mutations to this gene, called alpha tectorin. Mutations in alpha tectorin result in poor frequency resp...Lifestyle accounts for difference in chimp, human genome
... came from a particularly strong sign of selection acting on the gene that codes for an obscure protein in the tectorial membrane of the inner ear. One form of congenital deafness in humans is caused by mutations to this gene, called alpha tectorin. Mutations in alpha tectorin result in poor frequency resp...A first glance at global genetic networks
...enes) are more likely to develop many connections, acting as a hub. Following these organizational principles, transcription networks would have a relatively small number of highly connected "hub genes"--though a much higher number than one would expect in a random network. And that is what the authors obse...New advances in thrombosis help further understanding of disease prevention
...udy to investigate razaxaban, a new oral, directly acting inhibitor of coagulation factor Xa. Results showed that razaxaban administered at 25 mg twice a day (bid) appears to reduce the risk of venous thromboembolism after major orthopedic surgery with similar safety compared to current standard therapy, e...