Molecular motor implicated in tissue remodeling
...ent of individual tissue types. The model of MMP-1 action revealed by Goldberg and his colleagues might help explain how the enzymes that digest collagen serve constructive purposes. "The enzymes aren't loose and disorganized where they would just end up destroying the matrix," Goldberg states. "By mechanis...Researchers identify protein promoting vascular tumor growth
...vels safely, because the protein also is called to action to help wounds heal. Macrophages recruited in these cases make free radicals and promote angiogenesis that is beneficial in the wound-healing process. "There are times when you want to promote angiogenesis, but not with tumors, because it...Winning combination to build bone density in children
...take. This study provides evidence for synergistic action of habitual vigorous activity and calcium intake on bone mass in children. Recommendations for optimizing bone mass should reflect this synergism.......o guide the therapeutic to its correct location of action and ensure that pharmacological activity is maintained for an adequate duration once there." Professor Duncan's research (funded by CRC, now Cancer Research UK) led to the transfer of the first polymer-based anticancer conjugates into clinical trial...16 APS exercise research highlights, from reduced flu mortality to proteomics & obesity
...ersity of Massachusetts, Amherst) Improved insulin action following short-term exercise training: effects of exercise or energy balance? Study suggests that subtle changes in energy balance that precede measurable fat loss play a key role in mediating the beneficial effects of exercise on whole-body insulin...Wisconsin scientists develop quick botox test
... spur the development of agents to blunt the toxic action of the world's most poisonous substance. Writing t...to reveal molecules that may inhibit various toxin action pathways." Botulinum toxin is made by a bacterium that causes food poisoning. The poison is the mos...Marijuana use could cause tubal pregnancies
...receptors (adrenergic receptors) that through the action of noradrenaline, a neurotransmitter regulate muscle contraction. Wang, who led the study, has received two Lalor Foundation fellowships supporting research in reproductive biology. Subsequent experiments supported a new concept: the CB1 receptor mo...Key stimulator of colorectal cancer identified
.... However, the exact mechanisms of this protective action are unclear. PGE2 is a metabolite of COX that is elevated in CRC and has been implicated in disease development and progression. Peroxisome proliferator-activated receptor d (PPARd), a regulator of cell survival, has also been linked to CRC. Dr. Raym...JCI table of contents September 15, 2004
...made from the breakdown of arachidonic acid by the action of an enzyme called COX have been implicated in th... anti-inflammatory drugs, which act to inhibit the action of COX. Two prostenoids called PG I2/prostacyclin (PGI2) and thromboxane A2 (TXA2), are ele-vated i...Picking prostanoids to provide protection
...made from the breakdown of arachidonic acid by the action of an enzyme called COX have been implicated in th... anti-inflammatory drugs, which act to inhibit the action of COX. Two prostenoids called PG I2/prostacyclin (PGI2) and thromboxane A2 (TXA2), are ele-vated i...Genetically modified bacterium as remedy for intestinal diseases
...eidler and Erik Remaut) concerning the therapeutic action of IL-10 bacteria. Thus, this method of working with genetically modified bacteria offers promising prospects for the treatment of both acute and chronic intestinal inflammation, and it can potentially be extended to other therapeutics as well....First glimpse of DNA binding to viral enzyme
...nzyme's function, looking for new ways to stop its action and, therefore, block an adenovirus infection (see: http://www.bnl.gov/discover/Spring_04/anti_viral_1.asp ). The scientists didn't expect the viral DNA to bind to the protease, but they figured they should look just to rule out such an interact...Can an old gene learn new tricks?
...tterns in the fruit fly, Drosophila, the ancestral action of the Hmx gene was limited to the development of the central nervous system (CNS). Dr. Thomas Lufkin from the Genome Institute of Singapore and colleagues show that the mouse Hmx2 and Hmx3 genes have apparently interchangeable functions in CNS deve...A probable cause for high blood pressure identified - shows links with diabetes
...en an antagonist (another molecule that blocks the action of the first) is given, imidazole-4-acetic acid-ribotide's high blood pressure effect is inhibited. While some causes of high blood pressure are clearly established, the majority of cases are considered "essential hypertension," that is high blood p...Charting the future in prostate cancer care: A call to action
...r findings of the Report and its authors' calls to action to address the urgent need to improve the management of prostate cancer and accelerate the development of better treatments and a cure. The PCF will also debut a public service announcement campaign "It's a TEAM Approach: Prostate Cancer Treatment, ...Cell's gatekeeper for ammonia revealed in unprecedented detail
...e excreted from these organs. "Knowing the mode of action of Rh factors, we now know the basis of ammonia transport from tissues to the kidney, and the molecular-level mechanism for ammonia excretion via the kidney," Stroud explained. The structural basis for ammonia transport by AmtB is essentially the sam...Ventilation in bars, casinos doesn't control health risk for hospitality workers
... health of these workers." Few states have taken action to protect hospitality workers; only 14% of states have laws banning smoking in restaurants, bars, casinos and all other workplaces. According to the federal Agency for Toxic Substances and Disease Registry, people exposed to polycyclic aromatic hyd......thal havoc in cells targeted for apoptosis. Smac's action is why it was named the "second mitochondria-derived activator of caspases." Specifically, Wang and his colleagues sought to make a small molecule to mimic the function of the Smac protein, since a smaller molecule is better able to pass through the...Common cold virus can cause polio in mice when injected into muscles
...normally infected by polio. In studying the virus' action within infected mice, they found that the virus traveled from the calf muscle where it was injected to the central nervous system along "motor neuron axons." Such axons extend from the central nervous system to muscles throughout the body and convey ...Recent evolution at a single gene may have brought down heart disease risk in some human groups
...un around 24,000 years ago, is attributable to the action of natural selection favoring the variant, according to statistical analyses of genetic variation in several human populations. The researchers' new work also showed that the mutation that created the variant occurred at a site unusually prone to g...