From science fiction to reality: Nanomedicine brings fresh hope to the medical world
...ine holds the promise of site-specific therapeutic action and consequently, fewer side effects," says Technical Insights Industry Analyst Rajaram Sankaran. "Such site-specificity holds the promise of a better risk-benefit ratio and thus enhances the prospects for nanomedicine applications." The advent of na......s involved in appetite. Leptin works through the action of several small proteins called neuropeptides, such as thyrotopin-releasing hormon. Many of these neuropeptides are first made in a longer inactive form (called a prohormone) and are subsequently cut into a smaller active form; this is called prohor...Ecologist calls for creation of an international panel to assess human behavior
...n deaf ears,'' he argued. ''The locus of necessary action has shifted into the domain of the social sciences - and thus an MAHB - to find ways of bridging the disconnect.'' Academic challenges Ehrlich also said that members of academic communities faced a great ethical challenge: ''Can we become moral ent...Forest managers can fight invasive species that come with roads
...es is good monitoring by forest managers and quick action against new satellite populations, according to Radeloff and Hawbaker. "It actually pays to be proactive in this case," says Radeloff. And, as the window period gets shorter when road density increases, another solution is to carefully consider wheth...Two-pronged attack targeting EGF receptor hinders cancer cell growth
.... They are small molecules that interfere with the action of EGFR to phosphorylate proteins inside the cell. Iressa or Erlotinib block the EGFR kinases from adding phosphate groups to other proteins within the cell. Used together, the monoclonal antibody and either of the small molecule kinase inhibitors ...DFG presents the 2004 MAK and BAT value lists
...f 2 mg/m 3 was suspended because the mechanism of action is unclear. Benzoyl chloride, ethyl chloroformate, 2,5-dimethoxy-4-chloroaniline, glyoxal and 1,5-naphthylene diisocyanate were also classified in this category as suspected carcinogens. There were 15 examinations or new listings for carcinogenic wo......e RNA interference machinery, provides the cutting action that carries out RNAi-mediated messenger RNA cleavage. The studies were conducted at Cold Spring Harbor Laboratory by research groups led by Greg Hannon and Leemor Joshua-Tor. Hannon's group focused on sorting out the functions of four mammalian Argo...Insecticide resistance: A constraint on evolutionary change
... AchE1 protein was indeed resistant to insecticide action in the test tube, suggesting that the mutation would confer resistance to the mosquito in principle but that for some reason the mutation does not appear in Ae. aegypti populations. Looking more closely at the Ae. aegypti gene sequence for AchE1 ...Yale scientists visualize details of how hepatitis C unwinds RNA
...a that helicases move smoothly with the continuous action of a snow plow. Instead, NS3 moves with a discontinuous stepping motion that alternates rapid translocation with pausing. "We observe that the helicase proceeds through discreet spatial and kinetic microstates," Pyle said. "We actually track the spee...Rutgers cancer prevention expert calls for FDA action to reduce colon cancer and osteoporosis
... help make this happen. Newmark's call to action involves the simple addition of calcium and vitamin D to the existing FDA-mandated enrichment mix in products such as bread and pasta. He contends the measure could save 11,000 lives and an estimated $3 billion in U.S. health care costs annually. But...New view of leukemia cells identifies best treatment options, Stanford researchers say
...ys that translate a signal in the environment into action in the cell's nucleus. In all cells, a carefully orchestrated network of molecules passes messages between the cell's surface and the nucleus. Molecules that relay those messages follow a strict order in healthy cells, always handing the note - in th...Antimalarial substances found in New Caledonian sponges
...sing feature of these phloeodictines' antimalarial action is that, in vitro, it is accompanied by very low c... models, and to attempt to unravel phloeodictines' action mechanism....Why some neonates need caffeine
...re believed to be an important target for caffeine action in premature neonates. Peripheral chemoreceptor ac...siveness (associated or not with a direct, central action of caffeine) remains debatable, particularly in human neonates. Past studies were performed in anima...Significant strides in small regulatory RNA research in plants
...standing the biological functions and mechanism of action of this fascinating and important class of regulatory molecule. ...Carnivore extinction risk determined more by biology than human population density, says study
...rginia, USA, and the Institute of Zoology, suggest action now would offset greater danger later: "Arguably, ...tinction," they conclude. They suggest pre-emptive action including the establishment of population monitoring programs, or listing species under national spe...Carnegie Mellon neuroscientist develops tool to image brain function at the cellular level
...the fosGFP mouse to study Clozapine's mechanism of action may provide a better understanding not only of which neurons are activated by the drug, but also how they change on continued exposure to the drug....New study in moths shows insects not entirely ruled by instinct
...to do with food. "More neurons were recruited into action when a moth smelled the odor connected to food," Daly said. "After a few exposures to this odor, moths automatically started sucking for the food, even when they weren't rewarded with food. They also learned to not respond to the odor that was unrela...Gene therapy alternative to calcium channel blockers
... the first successful gene therapy that mimics the action of calcium channel blockers, agents widely used in... decreased calcium current densities the chemical action of calcium channel blockers by 30 percent to 90 percent, when compared to a control group. Indeed...Structure solved at Scripps shows how one human protein reduces potency of chemotherapy
...ein called AGT that is known to interfere with the action of certain chemotherapy drugs. AGT repairs damaged DNA inside human cells. Cancer cells can use it to repair DNA that has been damaged in the course of chemotherapythus rendering the chemotherapy ineffective. The structure of AGT, which is being r...Chemoradioimmunotherapy for advanced breast cancer: hope for the future?
...ar downregulation of HER-2 as a consequence of the action of antiHER-2 scFv antibody; 2) there was re-expression of the tumour suppressor gene BRCA1 as a consequence of the inhibition of the DNMT1 mRNA and; 3) the radioisotopes had induced DNA double strand breaks in the tumour cells. The combination of the...