How DNA repair machinery is a 'Two-Way Street'
... cell's DNA repair machinery to adeptly launch its action in either direction along a DNA strand to strip out faulty DNA. Such flexibility exemplifies the power of the repair machinery, which guards cells against mutations by editing out errors that occur during the process of chromosome replication. Malfun...Innovative efforts target epigenetics, molecular imaging
...ohns Hopkins and Harvard centers will implement an action plan to encourage underrepresented minorities to pursue education and careers in the field of genomics. Dr. Feinberg and his colleagues will offer select, Baltimore-area high school students the chance to conduct genetic research during their summer ...Hopkins to found first center for comprehensive study of epigenetics
...and his colleagues will also implement a "minority action plan" to encourage racial and ethnic minorities to...be principally involved with the center's minority action plan. Feinberg is also a member of the McKusick-Nathans Institute of Genetic Medicine at Johns Hopki...Joslin researchers identify key molecule in Type 1 diabetes progression
...like guided missiles), the researchers blocked the action of ICOS to see what would happen. Blocking ICOS disrupted the balance between T effector and T regulatory cells, and provoked insulitis to immediately convert to diabetes. The researchers concluded that ICOS plays an important role in keeping insul...Protein believed to control formation of memory identified by Scripps & UCSD scientists
...CSD) School of Medicine have demonstrated that the action of a protein called CBP is essential for the stabilization of long-term memory, a discovery that may help children with a rare but debilitating developmental disorder. They found that when the functions of normal CBP is suppressed in adult rodents,...UK small firms pay lip service to green issues
Government emphasis on voluntary environmental action is unlikely to have a significant effect on the environmental practices of SMEs, according to researchers at Kingston University who will present their findings at the Environment and Human Behaviour Programme seminar at the Policy Studies Institute ...Targeted therapy for lung cancer patients shows promise in extending lives
...arceva "aims to slow cancer growth by blocking the action of a molecule called the epidermal growth factor receptor, or EGFR, a protein found in the cell membrane of some cells, but found at an abnormally high rate in cancer cells. The protein triggers cells to divide at an accelerated rate, which allows th...Myths surrounding Cuyahoga River fire 35 years ago
...local authority and did not allow the city to take action against the polluters.The federal government had the River and Harbors Act of 1899 to grapple with pollution, but the general focus of the law was to keep waterways navigable for river traffic. The law barred disposal of wastes but not all liquid wa......ease and even starvation unless all countries take action now to slow global warming," said Michael Oppenhei...wledged, but policymakers and the public must take action now. "We're in the middle of a large, uncontrolled experiment on the only planet we have," Kennedy s...Fox Chase Cancer Center's Alfred Knudson Jr. named 2004 Kyoto Prize winner
...or at Northwestern University, whose communicative action theory and discourse ethics support a commitment to the elimination of discrimination and violence in human society, and the establishment of relationships of coexistence among all free and autonomous people. Knudson has been a senior member of the...Scientists receive awards, give lectures at the ASBMB/IUBMB meeting
...physiology of polyunsaturated fatty acids, and the action of prostaglandin. Dr. Jack L. Strominger, Harvard University, recipient of the 2004 ASBMB-Merck Award for outstanding contributions to research in biochemistry and molecular biology, will speak on MHC proteins and multiple sclerosis therapy at 8:30...Study of proteins offers insights into organization of biological networks
...otein partners interact, nor which partners are in action at the same time. "We need a way of analyzing proteins' activity as a dynamic process," Vidal says. Vidal and his colleagues focused on hub proteins, the social butterflies of the molecular world, which have large numbers of partner protei...Molecular marker predicts success of breast cancer treatment
...rapies for breast cancer. It works by blocking the action of estrogen on breast cancer cells. Estrogen directs the growth of normal breast cells, but can also stimulate the abnormal and unregulated cell growth associated with breast cancer. Unfortunately, nearly 40% of breast cancer patients fail to respond...Scientists discover way to regulate the body's energy expenditure
...t to determine the consequences of blocking RIP140 action in adult animals." This work was supported by the Wellcome Trust and the Biotechnology and Biological Sciences Research Council. Professor Parker and his team have recently signed a deal with CytRx, a US based biopharmaceutical company, t...When blood can't get to brain, special CT scan helps
... surface of the brain. Only a combination of quick action and neurosurgical skill can close the leak and save the patient's life. But even if they survive, patients have a high risk of ischemic stroke within hours or days of surgery, if their repaired blood vessels start to constrict uncontrollably. Many di...UCSD study shows how we perceive world depends on precise division of labor among cells in brain
... stimulus is because intensity will influence what action needs to be taken. For example, an uncomfortable shoe will become more and more difficult to ignore as your foot develops a blister. As the blister develops, the interval between subsequent electrical impulses arriving at the brain would decrease; ......ulation of its own synthesis. Block the hormone's action inside a few specific cells, the study shows, and the entire body stays healthier longer. Scientists previously thought insulin triggered other hormones to achieve this effect, but Tatar and his team found that insulin regulates its own production an...RNAi delivery system crosses blood-brain barrier to target brain cancer
...ed EGFR function in two ways. The EGFR is set into action when it binds a growth factor related to epidermal growth factor, a hormone growth factor that travels outside of cells in the blood. Activated EGFR normally induces a flow of calcium across tumor cell membranes. That calcium mobilization was minimiz...JCI table of contents, 1 June 2004
...2 indeed acts as a tumor suppressor and aids IL-12 action as an antitumor agent. TITLE: The IL-12Rbeta2 gene functions as a tumor suppressor in human B cell malignancies AUTHOR CONTACT: Irma Airoldi G. Gaslini Institute Genoa, Italy Phone: 39-010-563-6342; Fax: 39-010-563-6524 E-mail: laboncologia@ospeda...Cell growth and death controlled by single pathway in lymphoma cancer model
... not die. That meant something was controlling the action of p53." The team now had to determine whether this resistance to cell death was dependent on activation of the NF-kB pathway, so they treated the cells with molecules they knew would block NF-kB. They then exposed the transfected cells -- those in ...