Tag: "activation" at biology news
Researchers find new way to trigger self-destruction of certain cancer cells
...s free to put the brakes on. In cells lacking p53, activation
of the JNK cascade by rapamycin occurs so quickly ...3. The team showed that rapamycin caused sustained activation
of the JNK cascade; and that exposure of Rh30 cells to IGF-I completed blocked the activation
Hebrew University researcher studies 'reorganization' of brain in blind people
... brain. In contrast, no such verbal memory-related activation
was found in V1 of a sighted control group. This V1 activation, unique to the blind, was accompanied by superior verbal memory skills for the blind as a group, compared to their sighted peers. The test shows that the greater the occipital activation,...
Scientists find protein that controls prostate cancer's spread
...redicted that reduced RKIP levels pave the way for activation
of MEK, which in turn is involved in vascular invasion and metastasis. The researchers tested their theory by blocking MEK activity in some metastatic cells and blocking the action of other kinases in other cells. The cells with blocked MEK activity...
JCI table of contents, 16 June 2003
...val in different cell types. The mechanism of this activation
is not entirely clear. A new study shows that it i...activation. TITLE: AIP1 mediates TNF-ainduced ASK1 activation
by facilitating dissociation _of ASK1 from its inhibitor 14-3-3 AUTHOR CONTACT: Wang Min University ...
A new view of the crayfish brain
...ese-enhanced MRI, the scientists hope to determine activation
of multiple pathways simultaneously. "Our goal is ...ty marker for identifying entire patterns of brain activation
in dominant and subordinate crayfish," said Herberholz. "We also want to compare changes that occur ...
Chemists unlock secret to activating tumor suppressor gene
...tively common way to regulate membrane binding and activation
of many cellular proteins involved in cell signaling and membrane trafficking. Loss of PTEN regulation has been linked to various cancers, including the malignant and usually deadly brain cancer glioblastoma, and to endometrial carcinoma, or cancer ...
UT Southwestern researchers find immune system stages for eliminating viral infections, cancer cells
...llow further research to better understand NK cell activation
and possibly the development of tools to regulate NK cell behavior in combating cancer cells." The next step is to find out how the cytoskeleton of the natural killer cells is regulated and what signaling molecules and receptors are involved in the p...
UCR Plant cell biologists show that plants use unique mechanisms to process and degrade proteins
...molecules. The manner by which this degradation or activation
occurs, however, is uncertain. In the June 10, 2003, issue of the Proceedings of the National Academy of Sciences (PNAS), however, scientists from UC Riverside identify a key protein, v acuolar p rocessing e nzyme or VPEg, in Arabidopsis thaliana ...
Abnormal immune response may play major role in glaucoma, study says
...etermine if the eyes were actively suppressing the activation
of T-Cells (white blood cells that cause inflammation.) Although normal eyes successfully suppress these T cells, Streilein and his collaborators found that the eyes of the model mice failed in this regard. And this failure preceded clinical evidence...
Diabetes in the elderly linked to fewer cellular 'power plants'
...an enhance the number of mitochondria in muscle by activation
of a key enzyme called AMP kinase. "This is yet an... shown that exercise leads to more mitochondria by activation
of AMP kinase -- by staying active, the elderly might well able to maintain mitochondrial content an...
New Hair in 15 Days
... Medical School have discovered that the transient activation
of a protein called -catenin can induce new hair g...rsity of Michigan have demonstrated that the brief activation
of -catenin in telogen-phase adult hair follicles is sufficient to initiate the anagen phase. The -c...
U-M scientists trigger new hair growth in mice
...ts new about our study is the finding that a brief activation
of beta-catenin in resting hair follicles could be...hair growth would not produce a normal hair. Also, activation
of beta-catenin in the body would need to be tightly regulated, since uncontrolled beta-catenin acti...
Tiny protein prevents disease-related cell death
...vered in studies of Alzheimers Disease, suppresses activation
of the protein Bax. Bax triggers pathologic cell ...t could prevent or arrest diseases associated with activation
of Bax, says Dr. Reed. Dr. Reed envisions that the tiny protein humanin could be synthesized and d...
Genetic reconnaissance identifies new colon cancer genes
...essentially "turned on" in the absence of a normal activation
signal, which is called constitutive activation. This represents an ideal drug target, said Vogelstein, and is exemplified by the success of the drug Gleevec in treating chronic myeloid leukemia. "In the past, the search for drug targets has been g...
'Frontiers In Bioinformatics' symposium to be held by UB Center of Excellence in Bioinformatics
...deling, focuses mainly on growth factors, receptor activation
and signal transduction, which are important in cancer and other diseases. Previously, he worked on the enzymes involved in hypertension and AIDS. He is co-founder of Astex Technology Ltd., a drug-development company, and formerly headed Britain's fi...
A switch that makes a blood clot sticky found within the platelet membrane
...IIb-IIIa subunits is responsible for responding to activation
signals and, in return, causing groups of the activated integrin to cluster. "Remarkably, these regions are evolutionarily conserved V meaning the transmembrane region in GPIIb-IIIa is the same in apes or rabbits or mice as they are in humans," said...
Researchers discover effective method for killing prostate cancer cells
...new study, Nevalainen explored what happens if the activation
of Stat5 in prostate cancer cells is blocked. Using human prostate cancer cell lines and viral gene delivery of an inhibitory mutant of Stat5, Nevalainen and her colleagues found that blocking the activity of this protein in prostate cancer cells wi...
Purification of signaling protein may boost tissue engineering
...een destroyed by chemotherapy. The research on Wnt activation
and its role promoting the development of blood-fo... addition of a lipid molecule is necessary for the activation
of Wnt proteins. Co-authors on that article include Jeff Brown and Esther Danenberg, as well as rese...
Gene activated in 80% of breast cancer patients
...m 46 patients was tested. The rate ofexpression or activation
for Caucasian women with breast cancerwas 57%. Among African American women, it was 89%. According toBerg, While the research into BP1 may impact all groups withbreast cancer in that there was an overall higher expressionrate, the findings may prove...
Premature birth linked to lack of nutrition before pregnancy: study
... it is well known that the fetus does this through activation
of its adrenal gland to produce a surge of cortisol in the blood. The surge of cortisol is the catalyst for the chain of events that eventually lead to its birth. It is believed that human labour follows the same type of process. The problem is when ...
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