Cells may shoot messenger to halt protein production
...nd children, and may contribute to changes in gene activation in cancer. The mechanism involves a recently discovered enzyme that destroys the ribbon-like molecules of messenger RNA (mRNA). Messenger RNA is a copy of gene, and it contains information that describes the structure of a protein. It carries that in...Gene expression profiling may predict head, neck cancer recurrence
... subtype "shows an epidermal growth factor pathway activation signal, and that's potentially important because there are many new drugs in the clinic today that target that pathway," Perou said. Another subtype was associated with a "tobacco exposure signature," showing a high expression of genes involved in re...Protein may reduce susceptibility to autoimmune disease
...lude that increased expression of liCTLA-4 reduces activation of T cells and thus plays a role in preventing susceptibility to T cell-mediated autoimmune diseases. "The discovery of a new form of CTLA-4 was a completely unexpected result and demonstrates that the study of natural variation of genes altering au...New insight into how tumors resist radiation
...ke University Medical Center have investigated the activation of this protective response and whether the process can be successfully inhibited, thereby maximizing the effectiveness of radiation therapy. The investigators focused on a molecule called hypoxia inducible factor-1 (HIF-1) that is known to stimulate...JCI table of contents, 17 May 2004
...OMPANYING COMMENTARY: Amyloid at the cutting edge: activation of alpha-secretase prevents amyloidogenesis in an Alzheimer disease mouse model AUTHOR CONTACT: Christian Haass Ludwig-Maximilians-Universitat, Munich, Germany. Phone: 49-89-5996-471; Fax: 49- 5996-415; E-mail: chaass@pbm.med.uni-muenchen.de View t...Nonalcoholic beverages may impart cardiovascular benefits without the negative effects of alcohol
...In other words, nonalcoholic beer reduced platelet activation and blood coagulation just as well as the alcoholi... Perhaps a different method of inhibiting platelet activation would be to drink dealcoholized beer." Another finding of the study concerned only the nonalcoholic ...Scientists find second way to kill cancer cells: Discovery opens possibilities for new therapies
...ells. The rapid energy depletion was triggered by activation of a DNA repair protein, called PARP. Its activation leads to an inhibition of the cancer cell's ability to break down glucose to produce the cellular fu...New research at UNC shows ribosomes do not function as conventional enzymes
...e is characterized by lowering the enthalpy of the activation barrier and has often been observed. "In our pres...ontribution of enthalpy andentropy to lowering the activation energy barrier," she said. "Malte did this by comparing the energy barrier of the reaction when the ...Vanderbilt students take HHMI fellowships
... NSCLC and her study will test the hypothesis that activation of estrogen and associated growth factor receptors enhances growth of NSCLC, possibly offering new therapeutic targets. "I had planned on taking this year off to do research because I wanted to dedicate more time to this area," Weinberg said. "I hop...Could vitamins raise levels of bad cholesterol? Animal study suggests they might
...vitamin E, a well-known antioxidant, prevented the activation of the lipoprotein-breakdown pathway in rat and mouse liver cells. Thus, the liver destroyed fewer of the bad lipoproteins. The study also explains why polyunsaturated fatty acids, the good fatty acids found in cold water fish, are healthy for t...Recognition of bacteria in the cytosol by the immune system
...ng infection, and that this may play a key role in activation of the immune system. A surprising result came whe...lonize the cytosol do so in a manner that prevents activation of the immune system. ...Crowding stem cells' personal space directs their future
... simply grown in regular dishes in the lab, RhoA's activation or inactivation overrode signals usually used to direct their growth toward fat or bone," says McBeath. "But altering RhoA activity couldn't force a round cell to become a bone precursor, or a spread cell to become a fat cell on our micropatterns." ...APS announces four 2004 Young Investigators awards
...ting the role of Rho regulators in controlling the activation of RhoA. This research will shed light on the mechanisms of inflammation and edema, a hallmark of acute respiratory distress syndrome. Armin Just, M.D., Ph.D. University of North Carolina The Arthur C. Guyton Award for Excellence in Integra...Brain areas identified that 'decode' emotions of others
...ow, however, there has been no evidence that their activation can be intentionally controlled. "Our study shows that, not only will this brain activity happen when people passively react to an emotional stimulus, it also occurs when they actively search for mental state information," says Dr. Sabbagh. Problems...Genetic screening study at Stanford ID's most aggressive adult leukemia strains
...enes to the 133 that showed the most difference in activation between the groups. This handful of genes effectively discriminates between patients who have the most and the least aggressive cancers, and is a more manageable number for screening in a doctor's office. This study joins a growing body of research r...Introduction of the 'Rett protein' in post-mitotic neurons rescues Rett Syndrome in mice
...ally high levels in the brain. The timing of MeCP2 activation coincides with the maturation of the central nervous system and recent reports suggest that MeCP2 may be involved in the formation of contacts between nerve cells and may function in activity-dependent gene expression (i.e. learning). Multiple labs ...Gene with key role in replicating pox viruses also halts inflammation
...Shisler said. Because the K1L gene inhibited NF-kB activation in numerous cell lines tested, it suggests that its activity is global. Since this study was completed, the researchers subsequently have found a second protein that inhibits NF-kB, suggesting there may be multiple genes at work, Shisler said. "Thes...UT Southwestern researchers reveal mechanisms of smooth-muscle contraction
... recruited a second pathway to enhance the limited activation of MLCK, which leads to a strong muscle contractio...nsor that directly monitors the calcium/calmodulin activation of MLCK in real time in smooth-muscle cells. "These studies demonstrate the feasibility...The APCs of autoimmune disease
...mouse strain and now present data showing that the activation state of APCs plays a role in the development of a...e APCs in the EAE-resistant background had a lower activation state and lower T cell stimulating response than those in the EAE-sensitive strain. Furthermore, inn......mouse strain and now present data showing that the activation state of APCs plays a role in the development of a...e APCs in the EAE-resistant background had a lower activation state and lower T cell stimulating response than those in the EAE-sensitive strain. Furthermore, inn...