Tag: "activation" at biology news
Improving the body's 'homeland security' against TB
...vides a much sought-after link between immune cell activation
and TB inhibition," says MacMicking. "Previously we'd examined another pathway based on NOS2 but this was not the whole story. LRG-47 opens up a new way of thinking about the problem. It's the first step in a biologic process which one day could be m...
U-M scientists find genetic 'fountain of youth' for adult stem cells
...esearch "raises the possibility that inappropriate activation
or over-expression of Bmi-1 in stem cells could lead to uncontrolled growth and cancer." Morrison and his research team cultured central nervous system stem cells and neural crest stem cells removed from the brain and gut, respectively, of mice that ...
White House awards National Medal of Science to Rockefeller University's James Darnell
... Darnell's lab also has shown that the persistent activation
of a protein called Stat3 can, by itself, cause no...es showed for the first time that persistent Stat3 activation
could contribute directly to the transformation of cells into tumor cells. During the last 20 years,...
Embryonic pathway critical to growth of digestive tract tumors
...researchers. The researchers checked for Hedgehog activation
in cell lines and fresh samples of digestive tract...ier this year, a team from Hopkins linked Hedgehog activation
to small cell lung cancer, providing reason to anticipate Hedgehog's involvement in a variety of oth...
Better model of cancer development sheds light on potential angiogenesis target
...ous work, including their own, suggesting that Id1 activation
was an important step in tumor angiogenesis, a pro...ansplant. The tumors grew in the animals with Id1 activation
while the injected tumors failed to grow in mice whose Id1 genes were inactivated. "But this is n...
JCI table of contents, 15 October, 2003
...atory agents. To investigate the role of NF-kappaB activation
in macrophages during atherogenesis, de Winter and...mmatory factors. TITLE: Inhibition of NF-kappaB activation
in macrophages increases atherosclerosis in LDL receptordeficient mice AUTHOR CONTACT: Menno P. J....
First study to watch brain patterns when forgiving
...gests that it may be possible to demonstrate brain activation
change, concomitant with symptom resolution and / ...mponent. Results: Post-therapy, we found increased activation
in brain regions predicted on the basis of foregoing work in healthy controls. These included signif...
JCI Table of Contents, 1 October, 2003
.... The authors demonstrated that inhibition of PARP activation
blocked all the known pathways of hyperglycemia-in...nd acute liver failure generally results following activation
of one of two different pathways: (i) oxidative damage following ingestion of toxic agents; and (ii)...
Vascular disease and aging
...trated a progressive increase in oxidative stress, activation
of inflammatory mediators, and increasing endothelial dysfunction in both humans and animals. Yet individuals and certain rodent strains display different degrees of "physiological aging" at a given chronological age--suggesting a genetic component...
PET scans used to determine progression of HIV infection
...et. According to the study, the PET scans recorded activation
of the lymph nodes, which are involved in the body...mptomatic with low viral loads also had lymph node activation
in the neck, upper torso and pelvic areas. The researchers observed a tight correlation between the ...
Envisat observes resurgent ozone hole
...t data from MIPAS do show a high level of chlorine activation
over Antarctica. The ozone layer is most prone to ...y which this year still allows sufficient chlorine activation
over a large area and for a longer period than last year." MIPAS will continue to monitor the condi...
Novel proteins designed that block inflammation regulator associated with rheumatoid arthritis
...port in today's issue of Science that blocking the activation
of a regulator of inflammation called tumor necrosis factor (TNF) decreased swelling by 25 percent in a rodent model of the human disease rheumatoid arthritis. Elevated TNF levels are associated with the onset of rheumatoid arthritis. The uniqueness ...
SPR Annual Meeting features newsworthy discoveries
...simply neutral. Both men and women showed similar activation
patterns in an area of the brain called the visual association cortex when they were shown the images. There was one slight difference though. As you might have guessed, men showed slightly more brain activity in this area when they were shown eroti...
JCI Table of Contents, September 15, 2003
...lifornia in Berkeley report that it is the chronic activation
of the host immune system in response to HIV infec...l proliferation reflects a state of chronic immune activation
following HIV infection as opposed to simple compensatory proliferation. Hellerstein and colleagues ...
Lasker Award honors Rockefeller University biochemist for pioneering studies of gene activation
...strated. "Virtually all of what we know about gene activation
and its regulation in animal cells can be traced b...activity. Control of gene expression -- the proper activation
or silencing of genes in cells -- is crucial in the developing embryo, and many diseases arise when ...
UCLA study uses genetic profiling to distinguish types of leprosy
...ons between the two lesion groups found that LIR-7 activation
may actually suppress the immune system's defenses...tuberculosis bacteria sample to test whether LIR-7 activation
would suppress the ability of the immune system to directly combat microbial pathogens. Researcher...
Scientific equipment including the first European student experiment reaches the ISS
...s. In addition to the above experiments, a biology activation
unit for ROOT and GENE experiment has been uploaded. The next flight will be on the Soyuz TMA-3 spacecraft which will be taking ESA astronaut Pedro Duque to the ISS on 18 October. Pedro Duque will have other duties during the Spanish Soyuz mission to...
Study shows critical role for steroids in insect embryonic development
...edical Institute research associate, looked at the activation
pattern of the receptor for ecdysone. They found that this receptor is highly activated in an extraembryonic tissue called amnioserosa, a tissue that does not itself form part of the embryo, but is nonetheless required for embryonic development. Thum...
JCI Table of Contents
...immune response". TITLE: Constitutive p40 promoter activation
and IL-23 production in the terminal ileum mediate...ep in the evolution of an immune response. Optimal activation
requires 2 steps: (i) T cell receptor binding to the foreign antigen; and (ii) engagement of the CD2...
UNC researchers identify protein crucial to gene silencing
...signals affect the modulation of gene expression - activation
or repression - throughout the genome. Studies at UNC and elsewhere have shown that epigenetic phenomena underpin the shutting down of one copy of the X chromosome occurring in female mammals, and parental "imprinting" - in which a gene's activity de...
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