Growth hormone and IBD: Reduction of intestinal inflammation, promotion of growth
...ckground and results STAT3 (signal transducer and activator of transcription-3) regulates disease activity in experimental colitis and human IBD. Suppressor of cytokine signaling 3 (SOCS-3) and Src-homology tyrosine phosphatase 2 (SHP2) are negative regulators of Il-6 dependent STAT3 activation via the gp130 ...... why it was named the "second mitochondria-derived activator of caspases." Specifically, Wang and his colleagues sought to make a small molecule to mimic the function of the Smac protein, since a smaller molecule is better able to pass through the cell membrane to reach the cell's interior, where IAP-caspase ......ption of a gene that encodes another transcription activator known as Bmal-1, which is one of the known circadian genes. Bmal-1 drives the transcription of a protein called cryptochrome, which subsequently inhibits the ability of Bmal-1 to activate cryptochrome's own transcription. This feedback loop is what k...JCI Table of Contents, 15 July 2004
...velopment and function, the function of a receptor activator called RANKL. Ritonavir specifically inhibits the ability of RANKL to activate two cellular signaling pathways (one through a protein called NF-kB and the other through a protein called Akt) that are critical to the formation and function of osteocl...JCI table of contents, 1 July 2004
...ascular fibrin, plasminogen activator, plasminogen activator inhibitors, and airway hyperresponsiveness AUTHOR CONTACT: Scott S. Wagers Vermont Lung Center, Burlington, Vermont, USA. Phone: 802-656-8917; Fax: 802-656-8926; Email: Scott.Wagers@uvm.edu View the PDF of this article at: https://www.the-jci.org...Researchers show 'clot-busting' at stroke site is viable option
... intravenously with recombinant tissue plasminogen activator (rt-PA) within three hours of symptom onset were at least 30 percent more likely to have good outcomes compared to patients on placebo. That study led to the intravenous use of rt-PA as the only federally approved clot-dissolving treatment of ischemi...UCLA researchers recreate patterns formed by mammalian cells
...two proteins. The UCLA researchers knew the likely activator protein was BMP-2; it was produced by the cells and caused cells to draw together. One of the researchers, Dr. Kristina Bostrom, had recently discovered a new inhibitor of BMP-2, an unusually small protein known as MGP. The investigators theorized ...Tamoxifen stimulates breast cancer growth following alteration of estrogen receptor
...ve form. Instead, it acted as an estrogen receptor activator and encouraged tamoxifen-resistant cancer cell growth. Using a genetic screening technique, the researchers showed that this mechanism was also operational in patients. The findings indicate that PKA may be a critical determinant of how ER+...Junk DNA yields new kind of gene
.... To be turned on, genes must first be bound by an activator molecule. A common activator in yeast is a molecule called Switch/Sniff. While most genes are turned on by Switch/Sniff, SER3 is ...New insights on sirtuins, involved in gene expression and aging
...suggest how scientists might identify or design an activator to boost sirtuin activity using a structure-based approach. The research will be published Tuesday, May 18, in the Proceedings of the National Academy of Sciences. "We know that the Sir2 sirtuin silences gene expression and stabilizes the genome in...JCI table of contents, 2 April 2004
...mbinant Factor VII (FVII), a procoagulant reaction activator that is independent of FVIII and FIX. But this treatment is extremely costly and the recombinant FVII has a very short half-life, translating into more treatments. Katherine High and colleagues, of the Abramson Research Center in Philadelphia, provi...Tumor cell-specific therapy shows preclinical promise
...nto cancer cells. p53 works as a "transcriptional" activator that binds to specific gene sequences and triggers apoptosis in response to DNA damage. One region of the p53 protein, the C-terminal domain, facilitates DNA binding. In cancer cells, synthesized peptides (called p53C) derived from this region can in...Computer scientists develop tool for mining genomic data
...nts of DNA microarray data to cull the hundreds of activator and repressor candidates is actually the easy part. The real challenge is figuring out which of these genes, if any, are biologically meaningful. This requires a bewildering array of hit-or-miss wet-lab experiments that examine protein-protein and pr...Researchers uncover pathway that could lead to plant generation of human-like protein
...am has worked on three human proteins -- an immune activator called a macrophage activating factor, a type of collagen and a heat shock protein. They have done the work on three plants -- tobacco, arabidopsis and alfalfa. "What we discovered is that there is a very complex set of reactions that exist in plant...New method of identifying and isolating stem cells developed
... and just mate it with a mouse they expressing the activator gene in their favorite cells or tissue, the investigators say. Also participating in the research were, from the Fuchs laboratory, were Geraldine Guasch, Ph.D., Valentina Greco, Ph.D., Cedric Blanpain, Ph.D., William E. Lowry, Ph.D., and Michael Re...Newly identified genes may help predict outcome in childhood leukemia
... messenger receptor of intracellular response) and activator of protein kinase C, which plays a pivotal role in cell signaling systems; and G2, an interleukin (IL)-10 receptor alpha, which regulates immune and inflammatory response. ALL cases expressing higher levels of these genes were associated with bette...UCSD researchers find promising new avenues for treating infections
...plains Ghosh. "We are currently looking for this activator in mammalian cells," says Rebecca Phillips, graduate student in the Ghosh lab and the first author on the paper. "It may be possible to find a drug which prevents this interaction and protects cells from the toxin." The researchers are looking for m...Discovery may be first plant cell surface molecule that halts cell proliferation
...ceptor that has the structural features of both an activator and an RGS-like deactivator." Still, the researchers said, two interpretations may operate here. One is that the switches are simply physically linked. Or it could be that the 'off' switch and the 'on' switch are each regulated by external signals. T...Fe-TAML(R) activators developed at Carnegie Mellon decontaminate anthrax simulant
...anup tool for anthrax contamination. The Fe-TAML activator used with hydrogen peroxide can substantially decontaminate a cultured, benign simulant of anthrax, they said. This anthrax simulant is commonly used in the laboratory testing of agents designed to eliminate its more deadly cousin, which is considere...Fe-TAML(R) activators developed at Carnegie Mellon decolorize textile mill wastewater
...investigators used minuscule amount of one Fe-TAML activator (10-6 M concentration) and small amount of hydrogen peroxide (10-3 M concentration) to treat spent dye bath solutions found immediately after the dyeing operation and to treat dyes remaining in a biological treatment pond. Using Fe-TAML activators, t...