UT Southwestern researchers discover method of postponing labor in mice
...und to manifest the same types of changes in these activators at the end of pregnancy and during labor as humans." Co-activators have the capacity to alter chromatin structure around progesterone-responsive genes by increasing the acetylation of histones. The genes are active when the histones are acetylated an...Molecules discovered that extend life in yeast, human cells
...n activity. They are also searching for endogenous activators that may naturally exist in human cells. In the May 8 Nature , Sinclair's research group reported the first known genetic link between environmental stresses and longer life in yeast. Triggered by low salt, heat, or calorie restriction (to as low as...Fe-TAML(R) activators developed at Carnegie Mellon decolorize textile mill wastewater
...ry Division). "Our field tests show that Fe-TAML activators with hydrogen peroxide are highly promising for cl...of laboratory experiments showing that the Fe-TAML activators are useful in decolorizing a wide range of industrial dyes. Each year, approximately 53 billion gal...Fe-TAML(R) activators developed at Carnegie Mellon help cleanup paper and wood pulp manufacturing
...e. While the current study shows that the Fe-TAML activators are extremely promising in cleanup efforts, their ...at depend on those plants for food. While Fe-TAML activators are not yet optimized to the point where they could replace chlorinated bleaching processes complete...Fe-TAML(R) activators developed at Carnegie Mellon break down toxic pesticides
...tally friendly catalytic process involving Fe-TAML activators and hydrogen peroxide appears to totally break dow...dation of organophosphorus compounds using Fe-TAML activators of peroxide," Industrial & Engineering Chemistry Division). "These early results show that Fe-TAML a...Fe-TAML(R) activators developed at Carnegie Mellon decontaminate anthrax simulant
... environmentally friendlycatalysts called Fe-TAMLR activators has the potential to become animportant cleanup to... with anthrax. Potential military uses of Fe-TAML activators and hydrogen peroxide could extend beyond killing deadly biological agents, according to Collins, wh...Fe-TAML(R) activators developed at Carnegie Mellon remove recalcitrant sulfur from automotive fuels
...idation of sulfur compounds in fuels using Fe-TAML activators and hydrogen peroxide," Industrial and Engineering...ment of Energy. "We are working to develop Fe-TAML activators to clean fuels to the point where they will comply with stringent EPA sulfur standards slated to go ...Targeting transcription: New insights into turning genes on
...ctually affect regulator function." The artificial activators are much smaller than most known natural activators. Using the same kind of screening approach, the researchers now plan to search for small organic molecules that are structurally similar to their protein-binding peptides and to combine those molecu...Lasker Award honors Rockefeller University biochemist for pioneering studies of gene activation
...undreds of DNA-binding regulatory proteins, called activators and repressors, that control the rate of gene tran...mplexes that act like mediators or bridges between activators or repressors and the general transcription machinery, thereby providing the cell with added control...OHSU researchers discover molecular signaling system controlling aspects of embryonic development
...r tumors caused by abnormal regulation of Jeb-like activators pf Alk, would respond to drugs that target the interaction between Jeb and Alk. Further, other studies suggest that the Jeb-Alk signaling pathway may also be important in adults. So far, Weiss and colleagues have found the Jeb protein in adult neuro...New advances in thrombosis help further understanding of disease prevention
...d converted into thrombin by the action of various activators in the clotting of blood) and an increased risk for venous thrombosis. "Before we start testing for these genetic disorders prior to prescribing E+P, we will need to study this area further," Cushman said. Enoxaparin Treatment Improves the Gestat...'Suicide proteins' contribute to sperm creation
... cells, are regulated through a complex network of activators and inhibitors. Once activated, a "caspase cascade" ultimately cleaves and irreversibly alters the function of essential cellular proteins, leading to apoptosis. Not surprisingly, cells keep caspase activation under tight wraps. That's why it's intri...JCI table of contents, 2 April 2004
...rats, Bim expression increased. Blocking upstream activators of Bim or using Bim antisense to block Bim expression reduced neuronal damage. Of interest, in the hippocampus of epileptic patients, Bim appeared to be selectively down-regulated. These results suggest a means by which the brain may protect itself...Bim notes in the neuronal executioner's song
...rats, Bim expression increased. Blocking upstream activators of Bim or using Bim antisense to block Bim expression reduced neuronal damage. Of interest, in the hippocampus of epileptic patients, Bim appeared to be selectively down-regulated. These results suggest a means by which the brain may protect itself...Newborn lambs' central heating system could aid fat busting in humans
...Now we're looking at whether synthetic and natural activators of the genes that express PPARs and PGC-1 alpha have the same effect."...Insights on stroke from the peripheral blood suggest ways to develop markers and therapies
... therapies like the clot-busting tissue plaminogen activators so widely used today, drugs that restore blood flow and thus slow brain death. The development of functional MRI sequences (continuous images of brain activities) provided valuable new insights into how ischemic stroke progresses in humans during the...JCI table of contents, 16 August, 2004
...novel AMPK targets and/or the possible use of AMPK activators may be useful in providing therapy for healing during or after a heart attack. A related commentary in this issue by D. Grahame Hardy from the University of Dundee places these data in the context of what is currently understood about the molecular m...Putting energy into heart protection
...novel AMPK targets and/or the possible use of AMPK activators may be useful in providing therapy for healing during or after a heart attack. A related commentary in this issue by D. Grahame Hardy from the University of Dundee places these data in the context of what is currently understood about the molecular ...... plans to investigate exactly how their artificial activators work. "We haven't rigorously proven that they func...aid. The researchers also will try attaching their activators to different DNA-binding domains to see if that affects their activity....