Tag: "active" at biology news
International study findings link acne-like rash to effectiveness of new targeted cancer treatment
...d a reasonable quality of life, either being fully active
or at least still able to carry out light work. Cetuximab, also known as Erbitux, is a new targeted treatment a monoclonal antibody designed to home in selectively on a protein called the epidermal growth factor (EGFR). EGFR is found on the surface...
Researchers determine genetic cause of Timothy syndrome
... said Keating, mouse studies showed the gene to be active
in brain regions that were known to show abnormalities in autism. Cell culture studies of the mutated version of the channel revealed that it did not react properly to block calcium flow at the appropriate time. This abnormality could expla...
Rare childhood genetic syndrome identified
...wed that the gene encoding the calcium channel was active
not only in heart muscle cells, but in tissues of the gastrointestinal system, lungs, immune system, smooth muscle, testes, and brain including brain regions that are known to show abnormalities in autism. Keating notes, however, that autism is a c...
New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
...rst tried it in leukaemia after finding it was the active
ingredient in some traditional Chinese preparations. The drug works by causing changes in cancer cells, inducing apoptosis programmed cell death. It also appears to correct the gene responsible for making a flawed protein (the PMLRAR fusion protein)...
Phase II trials of second-generation antisense cancer drug planned following successful early study
...utics and we were able to identify a biologically active
dose," he said. Antisense drugs work by inhibiting...such a way that we could identify the biologically active
dose in the tumour tissue. Being able to identify the active
dose in this way gives us confidence th...
Award winning researchers reveal potential new role for Glivec
...y an international team has shown that the drug is active
against a rare type of cancer called dermatofibrosarcoma protuberans (DFSP) a malignant tumour that occurs in the second layer of the skin (the dermis). He said that complete control of the disease was achieved in eight out of 10 patients in a Ph...
UCSF scientist Joe Derisi named MaCarthur Fellow
...g researcher, a talented and dedicated teacher, an active
participant in university and public service, and a wonderful human being. Joe's impact to date has been well beyond our wildest expectation. Among the many lucrative projects that could be tackled with microarray technology, Joe has focused a signif...
Wildlife Conservation Society hosts public symposium on human-wildlife diseases
...sed at the Bronx Zoo, and Field Veterinary Program active
in dozens of countries around the world, WCS is uniquely positioned to convene the critical mix of expertise needed to assess the complex relationships between health, wildlife conservation, and stewardship of Earth's resources at this critical junct...
Marijuana use could cause tubal pregnancies
... CB1, a "cannabinoid" receptor that binds the main active
chemical for marijuana, delta-9-tetrahydrocannabinol (THC). In pregnant mice that lacked the gene for the receptor, or in which the receptor was blocked, the embryo failed to go through the oviduct the tube leading from the ovaries to the uteru...
Females may be more susceptible to overindulge 'sweet tooth' cravings than males
...plus sweet milk was monitored during sedentary and active
conditions. In sedentary rats (where the running ...ntake of the chow plus milk diet in both sexes. In active
males, diet-induced hyperphagia was abolished and caloric intake was reduced to that observed during...
New hydrothermal vents discovered as 'South Pacific Odyssey' research begins
...cluster of hydrothermal vents along a volcanically active
crack in the seafloor. About a mile and a half do...st of scientists since the late 1960s. Lined with active
deep-sea volcanoes and hydrothermal vents--along with massive sulfide deposits enriched in gold and ...
$7.5 Million grant to Yale researchers for role of viruses in cancer
... mechanisms for inducing these viruses to re-enter active
growth. Joan Steitz , Sterling Professor of Molecular Biophysics and Biochemistry , also works on herpesviruses, focusing on the role of small viral RNAs in the induction and maintenance of tumors. Many RNAs that she studies were first identifie...
Study explores gene transfer to modify underlying course of Alzheimer's disease
...e and facilitates its delivery to brain cells. The active
part of the drug is the NGF gene, the human DNA strand that codes for the NGF protein, a natural substance that exerts positive effects on brain cells. A key objective of the study is to deliver the CERE-110 directly to the part of the brain that is ...
Prion propagation: Avoiding the toxic oligomer
...rstanding the mechanism of propagation, an area of active
research. An abundance of small protein aggregates, called oligomers, is associated with amyloid fiber growth and formation. Mounting evidence suggests these amyloid intermediates are the "toxic species" underlying amyloid diseases. It is not...
Chemical genetics identifies SARS inhibitors
...udy has provided a reservoir of novel biologically active
small molecules that could be developed as anti-SARS therapeutics....
Resveratrol synthase uncovered: Cyclization specificity of type III polyketide synthases
...f cyclization is not regulated by the shape of the active
site, as was believed previously, but occurs because of an alternative electronic network, termed the aldol switch, that exists in STS. ...
Understanding celiac disease
...nal lining. However, the processes contributing to active
destruction of healthy tissue are not well understood. A research study headed by Dr. Bana Jabri from the Department of Pathology at the University of Chicago examined a receptor on CTL cells called NKG2D that can be activated by stress-induced chemi...
There and back again
...e team found that the expression of constitutively active
Cdc42 prevented mesenchymal cells from undergoing ...roporation of dominant negative and constitutively active
forms of Rac1 also indicated a role for that molecule in the mesenchymal-epithelial transition. Rac1...
Molecule awakens and maintains neural connections
...al signaling. During maturation, dendrites acquire active
AMPA receptors, and it was not known whether this process depended on Dasm1. Shi, the Jans, and their colleagues found that interfering with Dasm1 function drastically decreased AMPA receptor function. Their experiments also revealed that Dasm1 was ...
Researchers identify distinctive signature for metastatic prostate cancer
...established that the Hedgehog pathway was, indeed, active
in cultures of human metastatic prostate cancer cell lines. Blocking Hedgehog signaling with cyclopamine, a drug discovered by Beachy's group that targets another protein in the pathway, Smoothened, inhibited growth of these cell lines. Furthermore...
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