Nerve protein shown crucial to sensations of pain from heat, injury
...r, better known as the vanilloid receptor, or VR1, acts asa channel on the nerve surface. When certain compounds bind to it, the receptorchannel opens, allowing a stream of charged sodium and calcium molecules torush into the nerve cell. This generates an electrical signal that travels tothe brain to prod...Fox Chase Cancer Center molecular biologist named V Foundation Scholar
...d. The current hypothesis is that telomere length acts as a clock to limit the total number of divisions any cell is capable of achieving. This limitation on cell growth and renewal is believed to contribute to human aging. Activation of telomerase and stabilization of telomeric DNA circumvents ...Northwestern team identifies first enzyme in mammalian circadian clock
...dian rhythms in mammals, it is the first gene that acts as an enzyme. Circadian (Latin for "about a day") clocks are known to rely on a simple and elegant feedback loop of gene activation and inhibition. When that loop is working right, normal circadian rhythms of sleep and wakefulness adhere to a 24-...Pouch's newfound role tied to potential new treatment for malaria
...that it contains a pyrophosphatase, an enzyme that acts like a pump and allows protons to be transported inside it, and that the organelle has plant-like qualities. In the April 1 issue of the Biochemical Journal, the researchers reported that the organelle exists in Plasmodium berghei, a malaria-causing ......ipped up" together within a larger segment of RNA, acts as a boundary for the replication process. When ...ts that HIV is actually like telomerase -- when it acts in cells to make new viruses, it really is acting together with its RNAs. I think this is something ...Bone produced from skin and gum tissue
...ollagen sponges. The particular hydrogel they use acts like "reverse Jell-O," remaining liquid when cool and firming up when warm, says Rutherford. Injected as liquid into a lesion of any size or shape, the material gels as it warms to body temperature, holding the engineered cells in the appropriate pl...PRAECIS announces positive results for abarelix depot-M in two pivotal Phase III clinical trials
... a potentially new prostate cancer treatment which acts rapidly without causing a testosterone surge when therapy is initiated," said Marc B. Garnick, M.D., PRAECIS' Chief Medical Officer. "Based on the results of these trials, PRAECIS plans to continue clinical evaluation of abarelix depot-M and plans to...Cincinnati Children's researchers uncover critical food allergy pathway
...role in the body's response to allergens. Eotaxin acts to recruit eosinophils, a type of cell normally found in the blood, into inflammatory tissue. Drs. Rothenberg and Hogan developed a mouse model of eosinophil-associated gastrointestinal allergy and challenged the mice with oral allergens, mimicki...UCSF finding could lead to long-sought alternative to morphine
...mally receive and transmit pain signals. Morphine acts at so-called mu receptors. Nalbuphine is believed to act predominantly at kappa receptors. Others opioids work at delta receptors. But within each class there are subtypes of receptors and scientists are still working to tease out the impact the indi...Researchers decipher chemical 'cross talk' that determines survival of immunecells
...that rescues T cells from GR death signals. "Ras acts as a molecular switch at the nexus of several incoming signals and, in turn, activates a network of multiple pathways," Jamieson explains. Using cells with mutant Ras genes as probes, Jamieson and Yamamoto determined the specific Ras-initiated pat...Fruit fly model could explain how mosquitoes carry malaria: new drugs and vaccines on the horizon
... purge it from the body. Furthermore, the parasite acts like a chameleon, constantly changing its surface so the immune system is unable to recognize it. A transmission-blocking vaccine would not protect the person who originally becomes infected with malaria. Instead it would prevent the disease from sp...Study on chromosome ends may aid cancer research
...ry ends of chromosomes. The protein, called Pif1p, acts directly on the chromosome ends, called telomeres,... ways, Zakian said. The new paper shows that Pif1p acts on the telomerase pathway itself and interacts directly with telomeric DNA, a potentially attractive...Genetic 'switch' key to biotech patent royalties
...rst royalties for a genetic sequencing patent that acts like a molecular switch to expose encrypted characteristics of genes has netted University of Alaska Fairbanks biochemist John Keller $10,000. He received royalties from Research Corporation Technologies, a biotech company in Tucson, Ariz. examining ...Small molecules used to block proteins in HIV
...vent the possibility of drug resistance because it acts on a site that is less likely to mutate. "We think this might be a way to get in the back door and eliminate or reduce the problem of mutations and the possibility of drug resistance," she says. The "wedge" molecules were developed by taking pieces o...New crop protection method could save US farmers billions
... to take in choline, a carbon source in wheat that acts as a stimulant for the fungus that causes FHB. Farmers can safely apply a biological control agent, or "microbial spray," to a crop close to harvesting time because it simply increases the concentration of naturally occurring bacteria. No biologica...Isoflavone-rich soy products may prevent bone loss in women
...t did not influence bone turnover suggests that it acts in a way that may be different from estrogen or other agents currently used as treatments for osteoporosis. Additional perceived health benefits of the regular consumption of soy, such as reductions in the incidence of cancer and heart disease in som...More than 300 regularly prescribed medicines can damage the lungs
...n and public sale. There are also some therapeutic acts that appear on our lists, such as blood transfusion, laparoscopy, acupuncture, the insertion of catheters and various body punctures". And the specialists of the European Respiratory Society (ERS), which is celebrating its 10th anniversary in Florenc...Feeling nauseous? Research suggests your brain plays a role
... the stomach. This study showed that TNF acts directly upon neurons in the p... colleagues showed that when TNF acts on NST neurons, these neurons cause the stomach to stop all movement. This drama...Advances in animal medicine increase quality of life for older pets
...g called Anipryl, made by Pfizer Animal Health. It acts on one of the neurotransmitters in the brain responsible for nerve to nerve communication. The drug slows the natural destruction of the chemical compound dopamine in the brain. Because the problem is progressive, even if the drug works initially, ul......e encodes a protein which is secreted by cells and acts as a signal to other cells. Using the tools of molecular genetics, Neumann and Nuesslein-Volhard show that the first nerves in the retina activate the Sonic Hedgehog gene, which then instructs nearby cells to become nerves as well. These nerve cells ...