Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction
By specifically deleting the adhesion protein d-catenin, which is found exclusively in t...ient to produce cognitive deficits. Also, although adhesion proteins have been shown to be critical for synaptic plasticity, a process by which brain circuits c...Novel IBD therapeutic approaches reported from Washington Univ., Barcelona, LSU at APS meeting
...directed toward identifying and characterizing the adhesion glycoproteins that enable leukocytes to bind to va... endothelial cells. Drugs that specifically target adhesion molecules involved in leukocyte recruitment are effective in treating intestinal inflammation. The...News tips from the Journal of Neuroscience
... zebrafish Becker et al. Expression of the cell adhesion molecule L1 is generally correlated with regenerative success, but it only appears in mammalian axotomized central neurons when axons are within a permissive peripheral nerve graft. The fish homolog L1.1 is upregulated after spinal transection, and i...Select research highlights from current AACR journals
... in carcinoma cells arising in this important cell adhesion molecule are similar to defects recently identified in muscular dystrophies. The research was conducted at the Lawrence Berkley National Laboratories, Berkley, Calif,; the University of Iowa, Iowa City, Iowa; and California Pacific Medical Center Re...Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
... known as Decay Acceleration Factor, or DAF. "Cell adhesion is one of the first contacts between bacteria and host," said Dr Matthews. "Knowing the architecture of the bacteria target allows us to conceive ways to disrupt this adhesion, which may lead to potential therapeutic intervention." Dr Matthews' team...JCI table of contents: 1 September, 2004
... The transmembrane adhesive protein junctional adhesion molecule (JAM-A) is expressed in a large number of...h nodes and contact hypersensitivity in junctional adhesion molecule-A-deficient mice AUTHOR CONTACT: Elisabetta Dejana IFOM, via Adamello 16, 20139 ...Bright idea could doom cancer and viruses, say Purdue scientists
...ir targets, which tends to happen because of their adhesion to blood proteins," Morrison said. "But I believe the results are promising for the future of the fight against cancer and viruses, and I hope other groups will continue the work we have begun."...UV light, coatings reduce bacterial adhesion up to 50 percent
...e lower wavelength UVC light (254 nm) lowered cell adhesion by 15 to 50 percent, depending on the type of bact...t with tin dioxide. Higher intensity light reduced adhesion more than lower intensity UV light. Li says, "Our work is among the first studies of the combinat...Nerve cells 'guided' to repair spinal damage: Technique
...ected with peptides, molecules that stimulate cell adhesion and migration. "When nerve cells are placed at the opening of the channel, the peptides act like breadcrumbs to follow," says Molly Shoichet, lead author and professor of chemical engineering and applied chemistry at U of T's Institute for Biomateria...Scientists discover new intricacies in how ulcer bugs stick to stomach
...oping that through combined approaches to blocking adhesion we may be able to prevent infection," Berg says. "It's possible, though, that we may have to set our sights on decreasing the severity of infections, which will limit the damage to the stomach and reduce cases of stomach cancer and ulcers." ......egrins are cell surface proteins that promote cell adhesion and signaling. Crump et al. show that Integrina5 promotes the development of an outpocketing known as the first endodermal pouch, which in turn acts as a template and helps to pattern a specific region of the hyosymplectic cartilage. But the pouch ma...Early predictor of breast cancer aggressiveness
...east Cancer Research today. A gene involved in the adhesion of cells is less active in breast tumors with a poor prognosis than those that are less aggressive, researchers found. Measuring the activity of the ALCAM gene in primary breast tumors could give physicians advanced warning about the likely clinical...New insight into cancer metastasis
... separate from one another, losing their cell-cell adhesion and scattering, thereby allowing these cells to tr...breast tumor cells completely lose their cell-cell adhesion and infiltrate other tissues. "In many mouse studies you have great models and come up ...Biocompatibility to widen scope of biomaterial applications
...tions. "Thrombosis involving blood coagulation and adhesion of blood platelets to biomaterial surfaces as well as fibrous-tissue encapsulation of biomaterials that are implanted in soft tissues are two challenging issues for researchers in quest of biocompatibility," says Technical Insights Analyst Dr. James ...Researchers identify two potential protein targets for new drug therapies for pancreatic cancer
...FAP (fibroblast activation protein) and FAK (focal adhesion kinase) in tumor samples and surrounding tissue of...in enhances the ability of a tumor to grow. Focal adhesion kinase not only promotes cell growth but also helps tumor cells migrate. "Our hypothesis was th...UNC scientists block cellular enzyme activity involved in cancer progression
... several types of human cancers. The enzyme, focal adhesion kinase (FAK), is known to promote cellular movement and survival. Its over-activity promotes cancer cell growth and metastasis. The new study demonstrates for the first time that one segment of FAK called the FERM domain plays a crucial role in activ...JCI table of contents, 1 June 2004
...TITLE: Dynamic flow alterations dictate leukocyte adhesion and response to endovascular interventions AUTHOR CONTACT: Yoram Richter Tel Aviv, Israel Phone: 972-3-767-9000; Fax: 972-3-647-5351; E-mail: yrichter@biorest.co.il . View the PDF of this article at: https://www.the-jci.org/press/21007.pdf ACCOM...Nanoscale contact optimizes adhesion
...ckos and many insects may have evolved to optimize adhesion strength, according to new research conducted at t... the tip of such hairs which gives rise to optimal adhesion to a substrate via molecular interaction forces. For macroscopic objects, such optimal shape design ...Measurement clarifies role between protein structure and cell adhesion
...tudying the adhesive properties of the neural cell adhesion molecule (NCAM) -- a protein that helps bind the n...her -- have found that two opposing models of cell adhesion are both correct. "Our extremely sensitive technique allows us to directly measure how these protein...... how spiders stick to surfaces, and how strong the adhesion force is. The team used a scanning electron micros...kes the van der Waals force an interesting form of adhesion is that, unlike many glues, the surrounding environment does not affect it. The only thing that affe...