'Obesity gene' causes cancer of fat tissue, Schepens scientists find
... are obese early in life and develop tumors of the adipose (fat) tissue in adult life. About 25 percent of the transgenic mice develop tumors, while control mice, or normal mice, showed no evidence of tumor formation. The researchers also found that no tumors formed in other tissues of the body, just in fat...Tailoring mitochondria to the cell's needs
... in the cytoplasm. Likewise, mitochondria in brown adipose tissue (BAT), but not in most other cells, contain high levels of uncoupling proteins that allow OxPhos to generate heat rather than ATP. Lehman et al. now show that the transcriptional co-activator PGC-1 is limiting for mitochondrial proliferation...Estrogen a possible factor in obesity for both sexes, researchers say
... The lack of estrogen led to an increase in white adipose tissue, as well as insulin resistance and glucose ...t for the normal development and function of white adipose tissue in males....Is there a protective gene against alcoholism?
...me called lipase which increases energy storage in adipose (or fatty) tissue. Central administration of NPY in mice reduces anxiety, whereas NPY-deficient mice score high on measures of anxiety. In the normal variant of the NPY gene, one Leucine (Leu) amino acid is substituted by Proline (Pro) at position ...Say what? Neurons and fat cells have a dialogue in the lab
...are similar to those from deposits known as "white adipose tissue," the body's primary energy-producing fat store. The experiments showed that fat cells affect nerve cells' production of a messenger called neuropeptide Y (NPY). Also, the fat cells produce an as-yet-unidentified factor that influences the n...Control of fat cell development demonstrated using Sangamo BioSciences' ZFP technology
...ention as its role has emerged in the formation of adipose tissue, as well as in the pathogenesis and treatment of diabetes, cardiovascular disease and cancer." The data reported in the paper indicate that this application of Sangamos ZFP technology may improve understanding of these diseases and support the......in pancreatic b islet cells, hepatocytes, or brown adipose cells have all been described. Belke et al. now add to this list the CIRKO mouse, which lacks the IR specifically in cardiomyocytes. In young CIRKO animals, the heart is of normal structure but is reduced in size, apparently because the cells themsel...Children in lower socio-economic backgrounds at high risk for type-2 diabetes
...unknown, but mounting evidence suggests a role for adipose derived cytokines and tumor necrosis factor-a (TNF...overed adiponectin, a peptide hormone derived from adipose (i.e., fat) tissue, which is one of several new hormones involved in obesity and is related to susce...Fat cells transformed to resemble nerve cells
...ents in mice and human cells. In both cases, mouse adipose (fat) cells and fat cells taken from human liposuction procedures were treated with chemicals and growth factors and allowed to grow in the laboratory. "Within hours the treated cells in both models began to look like neuronal cells and began to pro...A message from nature to muskrats: 'Dont chill out'
...g voluntary diving, and active rewarming via brown adipose tissue (BAT) does not appear to occur until surfacing. Given these observations, the researchers hypothesized that hypothermia in diving muskrats may enhance their dive performance by lowering diving metabolic rate. The authors of Does Natural Hypo...Mercury associated with risk of heart attack
...ticipants to measure their exposure to mercury and adipose tissue samples to measure their levels of fish oil...iomarker of long-term exposure to mercury, just as adipose tissue fish oils are a marker of fatty fish intake. In addition, the correlation between mercury and...Could an anti-marijuana compound hold the key to body weight and appetite control?
...d system and leptin, a helical protein secreted by adipose tissue and acting on a receptor site in the ventromedial nucleus of the hypothalamus to curb appetite and increase energy expenditure as body fat stores increase, was reported. Specifically, a deficiency of leptin has been found in obese animal subj...Sudden removal of fat impairs immune function in rodents, biologists find
...uals from one of these groups had epididymal white adipose tissue removed, the second group had inguinal white adipose tissue removed, and the third group had a surgical procedure but had no adipose tissue removed. Half...A derivative of the green tea leaf may help with Metabolic Syndrome X, a potentially deadly disorder
...io of insulin:Glucagon were calculated. Abdominal adipose tissue was isolated and weighted. Results The ... significantly increased their weight of abdominal adipose tissue and ratio of Insulin:Glucagon, indicating increased adipose lipogenesis and deposit, and decr...3-D imaging inside living organism, using quantum dots
...in in its tail, as well as capillaries through the adipose (fat) layer around the mouse's ovaries. The resear...ography with quantum-dot labeling through skin and adipose tissue -- two of the most challenging tissue types -- the researchers said they had resolved several...JCI table of contents, 2 June, 2003
...glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1 AUTHOR CONTACT: Robert V. Farese Jr. Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA. Phone: 415-826-7500 Fax: 415-285-5632 E-mail: bfarese@gladstone.ucsf.edu Vi...JCI table of contents, July 1 2003
...ansgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice AUTHOR CONTACT: Jeffrey S. Flier Harvard Medical School, Boston, Massachusetts, USA. Phone: 617-667-9050 Fax: 617-667-9054 E-mail: jflier@caregroup.harvard.edu View the PDF of this article at: https://www......mia. TITLE: Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBb AUTHOR CONTACT: Robert S. Garofalo Pfizer Global Research and Development, Groton, Connecticut, USA. Phone: 860-441-1055 Fax: 860-441-0548 Email: robert_s_garofalo@groton.pfizer.com View...