Belgian researchers explore revolutionary approach to angiogenesis
...als in patients. "The chances for this anti-tumour adjuvant therapy to be well tolerated are high as ET-1 antagonists would be used acutely to produce an immediate effect on the tumour blood vessels i.e. given at the same time that the chemotherapy or radiotherapy is administered." He said that although the ...Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
...alone; a second group received the protein plus an adjuvant called Alhydrogel; and a third group served as the control, receiving an injection of saline solution instead of the vaccine. Purified RTA 1-33/44-198 protected 10 out of 10 mice from a whole-body aerosol challenge with lethal doses of ricin. T...Structure solved at Scripps shows how one human protein reduces potency of chemotherapy
...re currently being tested in clinical trials as an adjuvant for chemotherapy. The idea is that these inhibitors could be administered at the same time as chemotherapy to make chemotherapy more effective. "Having the structure solved allows us to make [inhibitors] that are [even] more selective," Pegg says. ...Endometriosis: Could angiostatic therapy be the new treatment of the future?
...ean that angiostatic therapy could be useful as an adjuvant treatment for endometriosis. "Angiostatic therapy mainly inhibits the development of new vessels. However, it also interferes effectively with the maintenance and growth of endometriotic lesions, and thus may be a promising way of preventing the re...Scientists learn how adjuvant makes vaccines effective
...eness. Aluminum salts, known as alum, are the only adjuvant approved for use in the United States for routine ...e he tried on rabbits. Again, the vaccine with the adjuvant was more effective than a vaccine containing the toxin alone. The adjuvant alum was first widely use...Study investigates breast cancer resistance to tamoxifen and possible way to reverse it
...ournal of the National Cancer Institute. Although adjuvant tamoxifen can reduce the risk of death for women with invasive breast cancer by about 15% over 10 to 15 years, many women do not receive any benefit from the drug. Even among patients most likely to benefit from tamoxifen--those with tumors that expr...Breast cancer patients failed by treatment with taxol and taxotere respond to abraxane
...atic setting, or had a relapse within 12 months of adjuvant taxane therapy. The patient population studied had a poor prognosis with 91 percent having visceral (lung and liver) disease, 65 percent with more than three metastatic sites and 88 percent demonstrating ongoing tumor growth while on Taxol or Taxote...APP reports Abraxane(TM) is active in breast cancer patients who failed taxol or taxotere
...atic setting, or had a relapse within 12 months of adjuvant taxane therapy. The patients enrolled in this study had a very poor prognosis, with 91% having visceral (lung and liver) disease, 65% with more than three metastatic sites, and 88% demonstrating ongoing tumor growth while receiving TAXOL and/or Taxo...Other highlights in the May 19 JNCI
...nical, that lead intentionally to proof-of-concept adjuvant trials is all too rare. But, as Pegram et al. remind us, it is not impossible," he writes. Contact: Kim Irwin, Media Relations, Women's Cancer Program Area, UCLA's Jonsson Cancer Center, 310-206-2805, kirwin@mednet.ucla.edu Multiple Sclerosis and ...Drug combo effective in advanced breast cancer
...nical, that lead intentionally to proof-of-concept adjuvant (Phase III) trials is all too rare," Sledge states in the editorial. "But, as (UCLA researchers) remind us, it is not impossible." Jonsson Cancer Center researchers first tested drug combinations in the laboratory with the goal of translating their ...Other highlights in the May 5 JNCI
... and a major criterion in determining the need for adjuvant chemotherapy. Although a biopsy can detect these metastases, there is a need for an accurate and noninvasive method of detection. Hisataka Kobayashi, M.D., Ph.D., of the National Cancer Institute, and colleagues developed a method in which nano-size ...Genetic signature may predict recurrence in colon cancer patients
...ng, potentially providing guidance in recommending adjuvant chemotherapy for certain Dukes' B patients. Furthermore, the ability to stratify this patient class into different risk groups could be a useful tool for aiding the development of new, targeted therapies for the disease. "It is well known that cance...Preoperative treatment with Arimidex(TM) allows patients to undergo less extensive surgery
...ore favourable overall tolerability profile in the adjuvant treatment of postmenopausal women with early breas...trozole) trial was the first to show that changing adjuvant therapy from tamoxifen to the aromatase inhibitor, anastrozole after 2 3 years results in a lower ri...JCI table of contents, 15 March 2004
... and show that such vaccination protects rats from adjuvant arthritis (AA), an autoimmune disorder. Analysis ...ITLE: DNA vaccination with CD25 protects rats from adjuvant arthritis and induces an antiergotypic response AUTHOR CONTACT: Irum R. Cohen The Weizmann Institut...Topical vaccine protects against inhaled ricin
...for vaccination in which the antigen is mixed with adjuvant and applied directly to the skin or on a patch that is applied to the skin. The vaccine was then applied either directly to the skin of mice or incorporated into a patch. After several weeks all the mice showed high levels of anti-ricin immune respo...VaxGen reports Phase I clinical trial results of anthrax vaccine candidate
...D. "Despite formulations that had a tenth of the adjuvant content, antibody responses at the higher dose lev...o determine the optimal concentrations of aluminum adjuvant and recombinant Protective Antigen (rPA) to induce an even greater immune response. (rPA is a purif...Scientists discover potential approaches to enhance existing cancer therapies
...yzed. Over half of the patients had received prior adjuvant tamoxifen therapy and all had discontinued tamoxifen more than two months prior to the PET study, to prevent antagonism with the imaging agent. The participants in the study underwent FES PET close to the initiation of their therapy and subsequently ...Presence of certain tumor markers for melanoma could signal best results for vaccine
...of the MAAs would benefit from surgery followed by adjuvant active-specific immunotherapy targeting of these MAAs." What's more, the results indicate there are potential patients with advanced melanoma disease who can benefit from immunotherapy and that molecular diagnosis can play an integral role in identif...Clinical trial shows timing of chemotherapy improves survival in breast cancer
...ium. "Since breast cancer is so common, and adjuvant drug therapy has already been found to be so effective, a way to make that treatment 31 percent more effective could potentially save thousands of lives per year in the United States alone," said Larry Norton, MD, Head of the Division of Solid Tumor ...First potentially clinically useful independent marker for lung cancer identified
... All had undergone surgery. Five had also received adjuvant radiotherapy and one had received radiotherapy and...ERCC1 are better off, whether or not they have had adjuvant treatment, because their more effective repair gene will swing into action against these stray secon...