National Toxicology Program Meets On Transgenic Animals
...do studies on the carcinogenicity of environmental agents more rapidly than using ordinary strains of rodents. The tests use fewer animals and cost less. Some of the issues to be addressed are: Is the NTP approach to evaluation and validation of transgenic models sufficient and appropriate? How can exis...Plants Thrive With Insect-Induced Immune Responses
...trigger an immune response against disease-causing agents is already on themarket. The UC Davis researchers suspect similar products aimed at plant-eatinginsects will be commercialized in the next few years. The wild radish study was funded by the National Science Foundation and the UCDavis Center for Popu...Long-Standing Puzzle Of Immune System Is Solved By UCSF Researchers
...that encode antibodies, proteins that mark disease agents fordestruction. This diversity provides the immun...yimmunologists believed that they targeted disease agents by adapting theirshapes to engage the microscopic invaders. But by the 1960s it becameclear that, r...Common Infection Linked To High Blood Pressure
...s bacterium is one of the mostprevalent infectious agents worldwide with a wide range of clinicalmanifestations, including coronary heart disease and stroke," says Peter. J.Cook, specialist registrar at Heartland Hospital in Birmingham, England. "Nowwe know that severe high blood pressure falls into the sa...New Sensor Will Detech Chemical And Biological Pathogens At Incredibly Small Doses
.... To detect many of these weaponizable biological agents (WBA), a sensor must beable to identify a pathogen at a measurement of parts per trillion. Technologyavailable during the Gulf War only allowed measurements of parts per billion. A novel sensor, developed by two Virginia Tech engineering faculty mem...Pitt Researchers Find Way To Block Cellular Growth Pathways And Inhibit Tumor Growth
...nd EGFR proteins. The investigators injected these agents intohead and neck tumors growing in laboratory mice. This "antisense" therapyeffectively inhibited tumor growth and resulted in cancer cell death, orapoptosis.......d inhibitors could act as effective therapeutic agents against arthritic lesions and might increase the rate of survival in various endotoxin-induced septic shock syndromes....Possible Trigger For Heart Failure Identified In Lab Animal Studies
... hypothesis'" is todemonstrate that treatment with agents that inhibit the production or action ofTNF prevent or reverse heart muscle dysfunction and damaging "remodeling" inresponse to the molecules' errant assault on the failing human heart, Bristowwrites. Co-authors with Bryant in Dallas are Lis......lide will eventually surpass otherchemotherapeutic agents as an effective treatment for cancer". Harbor Branch Oceanographic Institution, Inc. is one of the nation's premiernot-for-profit oceanographic research and education facilities, dedicated to theexploration of the world's oceans, estuaries, and coa...... changes inthe criteria and procedures for listing agents in the Report. A press release on the advisory council's review of these substances may beobtained at http://www.niehs.nih under news and publications or by telephoningthe contact listed at the beginning of this release. The FR notices are o......ective therapy." The study, "Antibacterial agents that inhibit two-component signaltransduction systems," by J.F. Barrett, R.M. Goldschmidt, L.E. Lawrence, B.Foleno, R. Chen, J.P. Demers, S. Johnson, R. Kanojia, J. Fernandez, J.Bernstein, L. Licata, A. Donetz, S. Huang, D.J. Hlasta, M.J. Macielag, K......s beenwell characterized as a catalyst for hunger, agents that mediate satiety are not fully identified.This seems to be a part of the puzzle." The next steps are to identify the precise structure of the CART peptides and to further exploretheir role in managing an animal's body weight, especially long-ter...New Study Shows White Males Have More Receptors For Patent Blood-Vessel Contracting Substance
...A receptor antagonists may be usefulas vasodilator agents in chronic heart failure and hypertension. "The gender differences observed in this study raise interestingquestions with regard to our understanding of the gender-related differences incardiovascular disease reported in epidemiological studi...Cystic Fibrosis Gene Protects Against Typhoid Fever
...ecule that protrudes from the cell membrane. These agents blocked the uptake of S. typhi by CFTR, thus identifying theprotruding CFTR segment as the S. typhi binding site through which it enterscells. "Uptake and ingestion of S. typhi by epithelial cells is part of the body'snormal protective response," exp...Biggest Acoustics Meeting Ever
...y vehicles, blood substitutes, and medical-imaging agents (3aPAa2). What Cats Hear When You Talk to Them A famous "Far Side" cartoon shows a dog owner giving a long lecture to his pet, who only comprehendshis name and registers everything else as "blah blah blah." In real life, scientists are studying h...Mouse Model Of Down Syndrome Offers Glimpse Into Role Of Specific Genes In TheDisorder
...low researchers to assess potentialpharmacological agents and various forms of environmental enrichment, suc...als can be used to assess potentialpharmacological agents and various forms of environmental enrichment for theirability to improve learning and behavior. Al...Micro-Plants Yield Pharmaceutical New Wave
...lve future needs for drugs, including anti-cancer agents and urgently-needed antibiotics," says Dr Blackburn who has been investigating the properties of microalgae for 20 years. Dr Blackburn said the two year project is part of a national collaborative super-project called the "Bioactive Molecule's...Spinach Enzymes Neutralize Explosives
...are a trigger to releasing biological and chemical agents storednearby,"said Dr. Manish M. Shah, the project's principal investigator. "The challenge is to have a process that is safe, easy to use, environmentally friendlyandpreferably mobile," Shah said. "EBDP destroys explosives in a very benignmanner." E......rbids experimentation or acquisition of biological agents or toxins formilitary purposes. "We think investig... U.S. might have been experimenting withbiological agents forbidden under current treaties, and that the bug somehow hadgotten out among the populace. A simil......nsors for detecting biological or chemical warfare agents withfunding from the Defense Advanced Research Projects Agency (DARPA). "Test-Tube Evolution" Mimics Nature Breaker sets up a system of natural selection through test-tubeevolution to produce DNA sequences with the characteristics he desi...