Aslera™ improves bone mineral density in lupus patients
...d therapy, and currently available anti-resorptive agents may not be sufficiently protective, so we need alternatives that treat lupus and provide benefits, such as preserving BMD," says Ellen M. Ginzler, M.D., coauthor of the study and Professor and Chief of Rheumatology at the State University of New York......reconstruction attempts using known DNA polymerase agents were often hindered, since even localized DNA lesions can cause these enzymes to stop operating, dooming the entire reconstruction process, explains Livneh. The sloppy R1 duplicating enzyme may prove pivotal in this respect due to its ability to tole......sms that protect the brain from bacteria and other agents in the blood that might damage it, said Frank Longo, MD, PhD, a UCSF professor and vice chair of neurology and SFVAMC chief of research. Longo and his colleagues now have found that a much smaller portion of NGF may carry NGF's most useful functio...Hopkins researchers develop method to predict response to chemotherapy
...d. The researchers currently are investigating agents that will block the MGMT gene and increase tumor sensitivity to carmustine. "The ability to detect the methylated form of the MGMT gene may provide a new way of pre-selecting some cancer therapy based on a tumor's chemical profile," says James G. He...Cell studies may further gene therapy prospects for head and neck cancer
...is model is useful for testing future gene therapy agents to determine the effects on normal epithelium and tumor cells. It's a great model to study gene therapy without having to test humans or animals. We wanted a model that best replicates what goes on in humans and we think our model does that."...UC Davis study shows spirulina boosts immune system
...tes and can potentially increase the expression of agents that stimulate inflammation, which also helps to protect the body against infectious and potentially harmful micro-organisms. Additional studies with individuals consuming spirulina are needed to determine whether these dramatic effects extend beyon...First gene therapy to calm pigs' out-of-sync hearts
...e study, the researchers primed 10 pig hearts with agents that increased their uptake of the gene and its carrier system. They then threaded a catheter into the artery that feeds the heart's AV node, infusing the node with an adenovirus carrying the inhibitory gene. Some pigs received the same viral carri...Researchers discover new mechanism of drug that alters genetic makeup of viruses
... design and production of a new class of antiviral agents to treat RNA viruses. Such viruses, a family that includes poliovirus and hepatitis C, use RNA as both their core genetic material and also to direct protein synthesis. A paper published in the December 2000 issue of Nature Medicine, by a team led......is a prime strategy for developing new therapeutic agents to combat solid tumor and hematologic cancers, suc...LDP-341 in combination with other chemotherapeutic agents are planned as well as Phase II studies. The first combination study, LDP-341 with 5-FU and leucovo...... alloys, trichloroethylene and two pharmaceutical agents long known to have medical benefits, but also with recognized risks for causing cancer. The final version of this tenth report will be prepared by the National Toxicology Program headquartered at the National Institute of Environmental Health Scienc...MIT develops filters for wastewater treatment, more
...Mayes continued. These include tethering chelating agents to the comb "bristles" to trap heavy metals from a filtrant, and tethering cell-signaling ligands to the bristles to encourage cell attachment to, for instance, a membrane being used as an artificial tissue material. To explore bioengineering possib...Coffee may protect against bladder cancer
...moderate the harmful effects of the cancer causing agents produced by smoking....... swelling. Paraptotic cells are also resistant to agents that block apoptosis. Intriguingly, the character...ent and degeneration, as well as novel therapeutic agents for cancer and neurodegenerative diseases. "We are fascinated by paraptosis because it appear......erous problems including cost and finding chemical agents which will have a strong affinity for the contaminant in question, without being itself toxic. Such agents would also have to biodegrade quickly. In previous studies, the chemicals used by scientists Vu...Trans-NIH collaboration with NIOSH initiates studies of racial and ethnic disparities in health
...ss., will study the role of physical environmental agents and psychosocial factors such as life stress in the increasing incidence of childhood asthma, particularly among socioeconomically disadvantaged children in inner city areas. The investigators hypothesize that stress experienced prenatally and durin...Biological warfare: an emerging threat in the 21st century
...e points to some two dozen conventional biological agents - including anthrax, Ebola and typhus - plus an un...ax, smallpox and other ``conventional`` biological agents aren`t frightening enough, Block also raises the specter of ``black biology`` - a shadowy science in...Veterinary researchers seek secret to reversing birth defects
...une health may be important for protection against agents or events that lead to many birth defects, but it also raises the question whether individuals with a compromised immune system are at greater risk for having babies with birth defects. Answering these questions could help unlock some of the secrets...JAK-STAT signaling keeps leukemia cells alive
...The work reinforces the view that chemotherapeutic agents inhibiting the JAK-STAT pathway might prove of considerable utility in treating LGL leukemia and perhaps other neoplasms....UK researchers find critical link for estrogens neuroprotective effects
...tremendous implications for developing therapeutic agents for treating brain injuries....... a long-standing goal of medical science, and such agents could contribute significantly to the treatment of an array of human diseases. Although the complement proteins are part of the immune system, they do not always limit themselves to potentially disease-causing invaders complement does not discrimina...