No role for simian virus 40 in human pleural mesotheliomas
...York, N.Y., September 25, 2004 Mesothelioma is an aggressive cancer of the chest cavity that kills about 2000 people a year in the United States. Seventy to eighty percent of patients with this rare cancer have had exposure to asbestos. It has also been proposed that simian virus 40 (SV40), a contaminant in so...Gene expression in liver tumors and patient prognosis
...hich suggests an involvement of these processes in aggressive HCC. "Our results indicate that HCC prognosis can be readily predicted from the gene expression profiles of primary tumors," the authors report. Furthermore, they suggest that the unique molecular characteristics of each subclass could be us...Columbia research to examine gene influence on severity of peridontal disease, therapy response
...ontitis is classified into two groups chronic and aggressive that are categorized based on clinical signs afte...ll study 120 patients 60 with chronic and 60 with aggressive periodontitis. Samples of inflamed gingival tissue from the patients will be analyzed to identify l...Spontaneous mutation produces new MAO A/B knockout mouse
...eights are smaller. The mice also show anxiety and aggressive behavior, especially under stress." Looking furt...the men of a Dutch family who show impulsivity and aggressive behavior." This mutation in the Dutch family's MAO A also produces a premature stop codon which prev...Hunting illusive signs of natural selection
...enes, TRPV6 might be involved in susceptibility to aggressive prostate cancer and since there is a large difference in the prevalence of prostate cancer between the European- and African-American populations, TRPV6 may be the selected gene. TRPV6 and TRPV5 are involved in calcium absorption. Northern Europeans...... the laboratory from one of the most resilient and aggressive cancers a virulent brain cancer known as glioblastoma. The new approach to tricking the cell-death machinery could be applied to a wide range of cancers where this pathway, known as apoptosis, has been inactivated. The researchers -- led by Xiaodon...Study reveals first genetic step necessary for prostate cancer growth
... tests that predict whether the cancer will become aggressive and the development of treatments to prevent the c... tumor suppressor would predispose mice to develop aggressive prostate cancer, the role of Rb in tumor initiation remained enigmatic. Further research is needed ...Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
...ter assists the invasion. Together they define how aggressive or virulent the bacteria are at attacking the host. Most families of adhesins belong to bacteria that cause a single disease, but the 'Dr' family of Adhesins makes far more trouble: it is responsible for chronic diarrhoeal, intestinal and urinary tr...Tiny molecules have big potential as cancer drugs, Stanford researcher believes
...l to all tumors. "It suggests that anything that's aggressive and metastatic may involve these proteases and respond to an inhibitor," he said, adding that the inhibitor would likely be used in conjunction with other therapies....Marijuana ingredient inhibits VEGF pathway required for brain tumor blood vessels
...sed therapies." Glioblastoma multiforme, the most aggressive form of glioma, strikes more than 7,000 Americans each year and is considered one of the most malignant and deadliest forms of cancer, generally resulting in death within one to two years following diagnosis. The disease is usually treated with surg...Jefferson scientists find gene expression pattern may predict behavior of leukemia
...se and predict whether or not an individual has an aggressive form of B-cell chronic lymphocytic leukemia (CLL), Jefferson cancer researchers have found. Scientists, led by Carlo Croce, M.D., director of Jefferson's Kimmel Cancer Center and professor and chair of microbiology and immunology at Jefferson Medica...Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
...rican women present at a younger age and with more aggressive disease. Explanations for these racial/ethnic differences have included socioeconomic factors, nutrition, medical comorbidities, and healthcare behavior. However, analyses demonstrate that higher mortality risk remains independent of these factors. R...More aggressive breast cancer tumors found in African American women
...Haven, Conn.--A genetic mutation related to a more aggressive form of breast cancer occurs four times more often...isease also develops at an earlier age and is more aggressive in African-American women. To explore the reasons for the differences, Beth A. Jones, assistant prof...Method to visualize gene activity may provide insight into normal development & genome function
...d be possible for cancer biologists to predict how aggressive a tumor will be from its early patterns of gene expression." "Cell fate decisions must be understood in order for any of the incredible medical potential of stem cell therapy to be realized," adds Dave Kosman, a research scientist in the Bier ...Activated signaling pathway may predict lung cancer patients' response to gefitinib
... than 15% of patients with NSCLC are cured despite aggressive surgical and chemotherapeutic intervention. Gefitinib, a cancer drug that interferes with the epidermal growth factor receptor (EGFR) pathway, is active in approximately 10% of NSCLC patients in whom standard therapy has failed. Although earlier stud...Ants protect plants better when jacked up on nectar
...meat in their diets. Some species of ants are more aggressive than others, and many plants don't have any choice...o as good a job of protection as a few of the more aggressive ants. In addition, the results suggest that loading up a mild-mannered ant on nectar makes the ...Iron can have negative side effects on people with kidney disease
... 25 years, noted "This study will likely stimulate aggressive clinical investigation of the issues raised by the findings of this experimental paper." The study provides support for the concept that parenteral iron formulations are potentially toxic. Rather than helping patients, iron therapy may exacerbate pro...FDA approves VYTORIN, first and only to powerfully reduce LDL cholesterol through dual inhibition
...hyperlipidemia, especially in people who need more aggressive treatment to reach goal," said Margo Denke, M.D., ...n be started on 10/40 mg. Patients requiring less aggressive LDL cholesterol reductions may be started at 10/10 mg. The dose of VYTORIN should be limited to 10/1...New view of leukemia cells identifies best treatment options, Stanford researchers say
... recognize the pathways most commonly disrupted in aggressive cancers could help researchers predict which patients won't respond to standard chemotherapy. Doctors could immediately propose that the person consider less common therapies. "This is the first time we've been able to look at cancer signaling m...University of Pittsburgh medical center among first to implant heart assist device
...y blood pump, the Heartmate II. Known also for its aggressive work to enable patients on devices to be discharged to the home setting, UPMC was the first center to discharge a patient still on a device to await a human donor outside the hospital. Based on UPMC's experience, the FDA later allowed patients implan...