Tag: "aggressive" at biology news

Breast cancer can be reversed in laboratory mice, scientists report

...turned on, the transgenic mice developed extremely aggressive mammary tumors; in many cases, the tumors metastas...of the breast tumors -- including many of the most aggressive and advanced cancers -- regressed to the point that they no longer could be detected by physical exa...

PTEN and prostate cancer--the devil is in the doses

...functional PTEN genes showed the most invasive and aggressive cancers. These results, the researchers say, show that PTEN plays a "crucial dose-dependent role in prostate cancer tumor suppression" and that progressive reduction of gene function induces progressive changes in the quantity and quality of molecula...

Dose of PTEN protein found to determine progression of prostate cancer

...determines whether the tumor will become either an aggressive cancer or take a slow path towards microscopic features of growth, but remain benign. This new understanding of the natural history of the disease could allow researchers to develop novel clinical strategies to diagnose, treat, and possibly prevent p...

Exercise and healthy weight delay cancer even among women with highest genetic risk

...can decrease cancer risk. Women may participate in aggressive monitoring programs that try to detect any cancer as soon as possible. A number of medications to prevent cancer (such as tamoxifen) are being evaluated in high-risk women. Surgery to remove the ovaries can reduce the risk of both breast and ovarian ...

Ki-67 biomarker a strong predictor of outcome for prostate cancer patients

...rtion of prostate tumor cells with Ki-67, the more aggressive the cancer. Prior studies involved small patient numbers and did not definitively establish the usefulness of the Ki-67 biomarker. "Our study conclusively shows that Ki-67 was the most significant determinant of distant metastasis and death in prost...

TIGR posts sequence data for parasite that causes trichomoniasis

... incidence of HIV transmission made possible by an aggressive immune response and a heavy influx of target cells for HIV. This response may increase the chance of entry of HIV in HIV-negative individuals. Conversely, in HIV-positive individuals, the hemorrhages that are frequently associated with T. vaginalis i...

JCI Table of Contents, 1 October, 2003

...ncer progression up to the stage of histologically aggressive but nonmetastatic disease. At the point when the disease spreads to additional tissue types and organs, TGF-beta appears to switch from a tumor suppressor to a pro-oncogenic factor. These data have important implications for understanding epithelial ...

Sick Kids researchers link maternal folic acid intake to decrease in deadly childhood cancer

...ommonly diagnosed malignant tumour of infancy. The aggressive nature of this tumour also makes it the most common cause of cancer-related death among children one to four years old. When a number of Sick Kids oncologists noticed a decline in new neuroblastoma diagnoses, they sought to investigate the cause. In ...

New study shows why hypertension affects black males disproportionately

... verified in young asymptomatic African-Americans, aggressive behavioral adaptations should be made early to minimize the progression and onset of cardiovascular disease. The methods used to evaluate arterial compliance and autonomic function in the study were safe, noninvasive and caused no discomfort to the...

Study of bees by UC San Diego biologist provides insight into evolution of bee communication

...compete for food, Nieh says it is advantageous for aggressive bees to arrive at a food source in large groups. Similar behavior occurs in other types of aggressive insects; for example, army ants arrive in "enormous hordes," according to Nieh. A scent trail with c...

Collapse of seals, sea lions & sea otters in North Pacific triggered by overfishing of great whales

...l value of harbor seals and because seals are less aggressive and easier to catch. As the pinnipeds became comparatively rare, some killer whales expanded their diet to include the calorically least profitable mammals - the sea otters - with rippling ecosystem effects. By the late 1990's low numbers of sea ott...

SPR Annual Meeting features newsworthy discoveries

... P3 amplitude as an index of severity in impulsive aggressive behavior -- Matthew S. Stanford, Sarah M. Conklin...trical activity of people with so-called impulsive aggressive behavior. This study showed that a particular component of the brain electrical activity (called P3)...

Unique two-part macroemulsion offers new approach to cleaning up contaminated aquifers

...in field testing the technique. "There is not an aggressive attitude toward cleaning up these spills," he said. "It's an uphill battle, and there are still a lot of old dry cleaner sites out there. But the contamination is not going to disappear by itself." Pennell sees the technique offering an efficient a...

Sick Kids researchers identify cancer stem cell for brain tumours

...ancer stem cells from different tumour types, from aggressive malignant tumours to more slow-growing benign ones, share similar properties to each other as well as to normal brain stem cells. This suggests that mutations that lead to cancer formation may have originated in the brain's own small numbers of stem ...

Fruit fly pheromone receptor first ever discovered linked to specific sexual behavior

... pheromone receptors exhibited abnormal sexual and aggressive behavior, this is the first study to clearly link a single pheromone receptor to a specific mating behavior, Amrein said. Besides chemical sensing, courtship in flies involves visual and auditory cues. Therefore, Amrein said, the finding in fruit fli...

Telltale prostate cancer protein key to breast cancer, too

...ers of the team previously reported EZH2's role in aggressive and metastatic prostate cancer. "EZH2 may serve as an excellent biomarker for determining a breast cancer patient's prognosis more precisely than current methods," says lead author Celina G. Kleer, M.D., an assistant professor of pathology at the U-M...

Cancer biologists and a cardiologist take a new look at aggressive tumors

...multidisciplinary approach to learn more about how aggressive cancer cells function and how they differ from poorly aggressive cancer cells. The study, which appears in the Sept. 1 issue of Cancer Research, may also suggest pot...

Endostatin promising treatments for AIDS-related cancer

...oughout the body. "It also makes KS an incredibly aggressive disease," Mallery said. But treating KS cells with endostatin in the laboratory seemed to stop the cells in their tracks the cells had lost their ability to migrate and invade in response to growth factors. While the laboratory results of the curren...

Protein profile predicts prognosis for lung cancer

...st appropriate action, which could range from more aggressive therapy at the outset to avoiding therapies that are more likely to hurt quality of life for the patient than to extend that life. The research involved investigators from the Vanderbilt-Ingram Cancer Center; Vanderbilt School of Medicine's departme...

UT Southwestern researchers define regions of human genes highly prone to mutation

...likely to occur, medical geneticists can take more aggressive approaches to discover the genetic basis of many human diseases. "We know the genome is very big, and there currently is no technology to remeasure every single letter of this 3-billion-letter code," said Dr. Garner. "A very significant byproduct of...

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