Tag: "aggressive" at biology news

Presence of certain tumor markers for melanoma could signal best results for vaccine

...reased expression or loss of MAA are of a selected aggressive phenotype with greater advantage to progress and escape host immunity, thus adversely affecting patients' overall survival," said Dr. Hoon. "These studies suggest that advanced staged patients with melanomas expressing the two or three of the MAAs wo...

OXiGENE announces commencement of Phase I/II clinical trial of Combretastatin A4 Prodrug

...dvanced stages of the disease. ATC is an extremely aggressive disease with a poor prognosis and no established standard treatment therapy. A Phase Ib trial of CA4P is also underway at the University of Pennsylvania's Presbyterian Medical Center, where researchers are studying the VTA in combination with a c...

USC researchers use gene therapy to prompt mouse cells to produce human collagen

...20," says Woodley, "they often have developed very aggressive squamous cell carcinomas." Ever since their successful cloning of the type VII collagen gene, Woodley, along with Keck School of Medicine associate professors of research Mei Chen, Ph.D., and Wei Li, Ph.D., as well as gene therapy expert Nori Kasahar...

OXiGENE announces phase II clinical trial of lead anti-tumor compound in thyroid cancer

...advanced stages of thedisease. ATC is an extremely aggressive disease with a poor prognosisand no established standard treatment therapy. OXiGENE completed Phase I safety trials of CA4P in 2001. Duringthose trials, one patient with ATC, who had exhausted all knowntreatment regimens used for this disease, re...

Wistar-developed antibody shows promise against brain tumors in Drexel trial

...r high-grade cancers of the brain, one of the most aggressive and deadliest forms of cancer, has shown promise i...ing to Brady. Patients with glioblastomas, a more aggressive form of tumor, usually die within 12 to 18 months. Of the 180 patients receiving the MAb425 injecti...

Researchers developing new arsenal in war against cancer

...o be effective, so we can use agents that are more aggressive and not get the side effects of chemotherapy," Brewer said. Researchers Shawn Swavey and Alvin Holder, along with students Lee Williams and Nathan Toft, working in the Brewer laboratory, developed the new mixed-metal supra-molecular complexes (med...

Researchers identify cause of aggressive childhood cancer

...rts. Malignant rhabdoid tumors are rare but highly aggressive cancers that usually appear in infancy. These tumo...umors and that it may be involved in certain other aggressive cancers in early childhood. This work has led us to realize the existence of an entirely novel tumor...

Hatchery salmon may endanger wild cousins

...kes several days. Moreover, hatchery steelhead are aggressive fish that could easily outcompete the more timid wild chinook for food. Indeed, when they reach the estuary, hatchery steelhead often have full stomachs but the chinook do not. As salmon continue to decline in the Pacific Northwest, some hatcheries ...

JCI Table of Contents, November 18, 2002

... leads to more and more boneloss and more and more aggressive growth of the tumor. Consistent with this scenario, inhibition of osteoclast activity not onlydecreases bone lesions but also reduces tumor burden in animals. Preliminaryresults from human patients treated with bisphosphonates, a group of drugsalso u...

A genetic basis for aggression and anger

...CLE 1: "Vasopressin V1b receptor knockout reduces aggressive behavior in male mice" AUTHORS: SR Wersinger, EI G...hrough its 1a receptor subtype, is known to affect aggressive behaviors. The vasopressin 1b receptor (V1bR) is also expressed in the brain, but has received much ...

Scientists tackle the question: 'What will it really take to stop global warming?'

...eenhouse effect. The study's call for prompt and aggressive energy research and development distinguishes it from the Bush administration's Energy Plan, which focuses on domestic oil exploration, and the recent United Nations Intergovernmental Panel on Climate Change "Mitigation" report, which indicates that ...

A red flag for lethal prostate cancer

... identify accurately those men who need immediate, aggressive treatment to prevent the cancer from spreading outside the prostate. Once prostate cancer metastasizes, or spreads, to other organs, it is usually incurable. "Over the past 50 years, there has been no significant improvement in clinical outcome for m...

Nurse intervention helps cardiac patients manage cholesterol

...xercise patterns. "Our research suggests that more aggressive treatment is needed to enable patients with a history of heart disease to manage their cholesterol, improve their health, and avoid complications," says Allen. "Further research on the long-term clinical outcomes and the cost-effectiveness of nurse c...

Penn study may explain cliche of 'hot-headed' men

...neurological basis for the clich that men are more aggressive than women, according to new findings by scientist...n capacity than men for actually 'censoring' their aggressive and anger responses." In the Gurs' work, they relied on established scientific findings that human e...

Hormone replacement therapy may improve breast cancer detection and survival rate

...ho use hormone replacement therapy (HRT) have less aggressive tumors and are more likely to be diagnosed through...mors and node-negative tumors--all signs of a less aggressive disease. "From this data it appears that HRT use had only beneficial effects on breast cancer detect...

Laboratory study explains clinical promise of anti-angiogenesis cancer drug

...wth of tumors in mice implanted with cells from an aggressive form of human breast cancer; kept new blood vessel...year. The results were striking. The mice with the aggressive human breast cancer "xenografts" that received TM had their tumor size suppressed by 69 percent, com...

Rockefeller researchers provide the first functional evidence for mammalian pheromone receptors

...l Chemical Senses Center report significantly less aggressive and sexual behavior in laboratory mice who were en...ormal counterparts. Normally, nursing females are aggressive toward other lab mice that intrude or invade their nest. The nursing mutant females, however, were l...

Plant compound kills brain tumor cells

...in the western United States kills the cells of an aggressive brain cancer that affects some children. The compound, cyclopamine, blocks a signaling pathway that appears to be important for the survival of medulloblastoma, a form of cancer for which there is no effective treatment. In an article published in th...

Smoking pot alters more than mood human immune system affected, USF/UCLA study finds

...y might be harnessed to treat patients with overly aggressive immune responses or inflammatory diseases like multiple sclerosis and rheumatoid arthritis." Receptors that react to delta-9 tetrahydrocannabinol or THC, the compound in marijuana that produces a high, have been found in tissues throughout the body ...

Combining Rb2 gene with radiation therapy quickens tumor cell death, Temple researchers find

...ers transplanted a correct copy of the Rb2 into an aggressive brain tumor known as a glioblastoma using a vector that is sensitive to the drug tetracycline. "When you have the presence of tetracycline, the Rb2 gene is in a silent state," says Giordano. "When you remove the tetracycline, you enhance the Rb2 ge...

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