Tag: "airways" at biology news

'Man's best friend' may be even better

...tor agonist, D-pseudoephedrine.The volume of nasal airways was assessed by acoustic rhinometry and resistance to airflow (RNA) by anterior rhinomanometry. Results In the first series of experiments, histamine delivered to the nasal passages of five dogs caused rapid increase in RNA from 0.75 + 0.26 to a ...

The area where carcinogens settle may be a key factor in developing lung cancer

... adjusted to ensure smooth transitions between the airways with realistic length, diameter, branching angles,...ent factors may be higher in diseased lungs, where airways can be constricted or completely blocked. Conclusions Cells located in the area of the dividing sp...

Benefits of lung surgery reported for emphysema patients

...ed, leading to large holes in the lung, obstructed airways and trapping of air because of reduced elasticity of the lungs. According to the NIH, emphysema costs more than $2.5 billion in annual health care expenses and causes or contributes to 100,000 deaths in the United States each year....

Cystic fibrosis gene therapy trial results encouraging

...y in the cells that line the airways. In turn, the airways accumulate thick and sticky mucus. Bacteria proliferate in the mucus and cause chronic infections that permanently damage lungs. Under the direction of Dr. Konstan, the research teams for this recently completed Phase I study delivered the healthy g...

New proteomic techniques reveal workings of bacteria linked to cystic fibrosis

...PQS might be important for early adaptation to the airways of young cystic fibrosis patients. If it is, then ...nalyzed samples of Pseudomonas aeruginosa from the airways of children ages 6 to 36 months, the first time samples have been so thoroughly analyzed among patie...

UI study discovers cells segregate molecules to control signaling

...n body has barriers such as skin and the lining of airways and gut that protect and separate us from the outs...were overgrown and showed abnormal structure." The airways of individuals with these airway diseases also undergo many cellular changes, including a thickening...

Bacterial infections alter allergic response

...ponsiveness (a measure of the "twitchiness" of the airways of these asthma-prone mice), levels of the cytokine IL-4, and total white cell count in the airways were all lower in the previously infected mice than in mice who were not infected. Levels of gamma i...

Causation between white blood cells and lung disorders confirmed

...on chronic inflammatory condition of the bronchial airways causes the airways to become over-reactive, thus producing increased mucus, mucosal swelling and muscle contraction. Th...

A bed of microneedles: Johns Hopkins scientists' gadget measures muscle cell force

...cle cells control the expansion and contraction of airways and blood vessels, the microneedle bed's ability to measure how a cell's environment affects the strength, duration and timing of cellular contractions should one day help shed light on medical conditions like asthma and high blood pressure, the rese...

Medical devices safe, but could be safer with better regulation

...scope is used to put sterile saline into the lower airways and then remove it so potential infectious agents and other causes of respiratory illness can be identified. In late November 2001, a group of Olympus bronchoscopes were recalled nationwide because of a loose port that could permit contamination. Th...

Researchers warn biotech advances could be misused by terrorists

...es past the lung's immune system and deep into the airways where they can cause disease. Antibiotic-resistant strains of bacteria help scientists determine which antibiotic therapies will be most effective in treating an illness, but former Soviet bioweapons builders are suspected using this technology to de...

World-first gene therapy for cystic fibrosis targets lung stem cells?

...ompound found in our lungs which 'conditions' lung airways to allow cells to take up the therapeutic gene. Ou... human lung cells this enables us to use the nose airways in mice to easily develop and test out gene therapy treatments. "By instilling a single dose of a de...

Pain-relief drug may prevent lung problems, blindness in premature infants

...k of development, is a chronic inflammation of the airways and the lung tissue of premature newborns. About 5,000 to 10,000 new cases of this disease are reported each year, according to the National Heart, Lung and Blood Institute. Retinopathy of prematurity is another common complication of premature birth...

Not all mammals vomit -- or how to study emesis in mice

...type-specific inhibitors that are effective in the airways but do not interfere with PDE4 activity in other t... the beneficial anti-inflammatory effects in human airways without causing human patients to feel sick and vomit....

JCI table of contents: October 1, 2002

...type-specific inhibitors that are effective in the airways but do not interfere with PDE4 activity in other t... the beneficial anti-inflammatory effects in human airways without causing human patients to feel sick and vomit. CONTACT: Debra Polomeno Public Relations Me...

Scientists unlock secret behind cause of chronic lung disease

...including asthma and emphysema. "The lining of the airways began to change and accumulate huge amounts of mucus. Elastic fibres built up the around the airways, leading to fibrosis, a condition that restricts the airways, reduces their elasticity and causing scarring of the airways. Over time other enzymes...

Genome Therapeutics, University of Southampton and Schering-Plough identify novel asthma gene

...ncreased likelihood of suffering from asthma. "The airways in asthma patients undergo a number of changes such as thickening of the airway walls and subsequent narrowing of the airway passage," stated Stephen Holgate, M.D., Medical Research Council Professor at the School of Medicine, University of Southampt...

Treating bacterial infections can help asthmatics

...k multiple tissue samples from the upper and lower airways of 55 adults with mild to moderate asthma. They looked for evidence of bacterial infections by culturing tissue samples and performing genetic analyses. None of the tissue cultures grew any bacteria, but DNA from Mycoplasma pneumoniae or Chlamydia pn...

CF Foundation seizes proteomics for drug discovery

... sticky CF mucus that causes major problems in the airways and digestive tract. Researchers know that the CFTR protein interacts with a large number of other proteins in the cell but are just beginning to understand what those proteins might be and how those interactions might be important in CF. Many prote...

Genomic study breathes new life into asthma research

...it triggers the characteristic constriction of the airways that is associated with asthma. The authors used microarray technology to analyse how gene expression changes during simulated asthma attacks. Microarrays are DNA-coated microchips that allow researchers to look at a large number of genes at one tim...

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