Tag: "airways" at biology news

Novel gene therapy approach in 1st human trials

...ts to transfer healthy genes into the cells of the airways of cystic fibrosis patients, explains primary inve...y in the cells that line the airways. In turn, the airways accumulate thick and sticky mucus. Bacteria proliferate in the mucus and cause chronic infections t...

Research uncovers new treatment target for cystic fibrosis patients lung infection

...patients suffer occur deep in the cells lining the airways or are localized on cell surfaces in the sticky mu...f incorrect genetic instructions, cells lining the airways remove too much salt and water from the secretions, and when they do that, they work very hard, Schw...

Right better than left in asthma medication for children

...ic albuterol does become less effective at opening airways after frequent, repeated use. In fact, it seems to actually decrease lung function if used too often for too long. Levalbuterol, marketed by Sepracor Inc. as Xopenex, has been approved as a bronchodilator for patients 12 and older since March 1999. D...

UNC, Duke researchers discover cause of mysterious pancreatitis in some people

...ate the salt and water content of cells lining the airways in their lungs. As a result, they produce overly thick and sticky mucous that traps disease-causing bacteria and other organisms in their lungs and leads to chronic infections and shorter lives. Such patients can also suffer from pancreatitis -- an i...

Study: control of chloride channels localized, discovery may boost cystic fibrosis treatment

... control. The work offers strong new evidence that airways have evolved highly efficient methods to flush away noxious particles. Such basic science information should help improve treatments for children and adults with cystic fibrosis, the most common lethal genetic illness among Caucasians in the Unite...

APS August/September journal hot picks

...deep inhalation to dilate methacholine-constricted airways was greater among allergy sufferers than asthmatic individuals, but it progressively reduced in rhinitis during exposure to allergens. Conclusions: The researchers concluded that the allergy subjects may develop similar airway inflammation and remo...

Cystic fibrosis patients show too little salt in lungs, will need long-lasting treatments

... or is it that too little salt leads to stuffed-up airways and a series of chronic, debilitating infections? ...was because the layer of salt and water that coats airways in the lung is only about a millionth of an inch thick. As a result, it has been extremely difficult...

Microbes and the dust they ride in on pose potential health risks

...e tiny dust particles can penetrate deep into your airways and react with lung tissue," Herman said. "During major dust episodes reaching Florida, there could be a correlation with increased respiratory problems." In addition to the dust itself, even small concentrations of fungal spores can trigger allergi...

Drug bottles containing natural rubber stoppers may place latex allergic patients at risk for reactions

...e-threatening allergic reaction that can constrict airways in the lungs, severely lower blood pressure and cause death....

Chemokines in allergic asthma

...chemokines and chemokine receptors in the inflamed airways of asthmatic subjects. They find that two Th2-restricted chemokine receptors, CCR4 and CCR8, are upregulated in the asthmatic lung following challenge with inhaled allergens. Several chemokines that bind CCR4 are also induced under these circumstance...

New protein is essential for lung development

...he healthy animals. Lungs have a complex series of airways that range from large tubes to small branches. The airways in the mice lacking Fgf9 appeared normal during early embryonic development, when the larger tubes f...

Researchers discover gene responsible for cilia, lungs' natural cleaning system

...ut 80 percent of epithelial cells in healthy human airways are ciliated, he said. They sweep mucous and trapped particles and disease-causing organisms into the throat where they are usually swallowed and eliminated. Ciliated cells are injured and lost when flu viruses infect the lungs, for example. Thi...

Mouse allergy contributes to inner-city asthma crisis

...llergies that trigger the wheezing and constricted airways of asthma. But while doctors have treated people who work with mice in laboratories for allergies to the furry creatures, until now, not much was known about mouse allergy in the general population. To fill this knowledge gap, Wood and his colleagues...

New technique will improve delivery of drugs and gene therapy for cystic fibrosis patients

...eted aerosol particles to smaller, harder to reach airways in the lungs of people with cystic fibrosis (CF). ...that contain the drug are too large to pass beyond airways that are partially obstructed by thick, sticky mucus, a condition resulting from the disease," says ...

Marathon runners, swimmers, and cross-country skiers beware: intensive exercise is bad for your lungs

...s on the athletes indicated an inflammation of the airways of half of those tested, compared with only one person in three of the control group. Beware of cross-country skiing in very cold, dry weather conditions! Paradoxically winter sports attracted most attention in the discussions in Florence, in the lig...

Hopkins research may bring 'sigh' of relief to asthmatics

...deep breaths also provide protection by preventing airways from closing in the first place. The findings may ...ug methacholine to study asthma because it narrows airways and causes wheezing in asthmatics, but not in healthy people. Then, in 1995, Hopkins researchersdisc...

Targeted genetics presents promising data from cystic fibrosis clinical trial

...-CF was delivered efficiently throughout the upper airways of these patients, despite the presence of thickened mucus in their lungs. Maximum levels of 0.1-0.6 vector-delivered gene copies per cell were detected 14 days following administration of a single vector dose. Vector was still present in some pati...

Virtual reality tool quantifies physics of a doctor's touch

...uch a system could provide visual feedback of real airways while the student is maneuvering the tube into the simulated patient on the screen; the simulation would provide the student with the proper tactile or pressure feedback, felt through the haptic interface. Kesavadas estimates the research team could...

Study shows receptor molecule facilitates introduction of corrected genes into cells

...re these receptors on the side of cells facing the airways and that if you can dress up viruses with UTP, you can fool the cells into opening their doors long enough for the virus to sneak in." The scientists are now attempting to boost the vector's efficiency in entering cells, Boucher said. After that, th...

Oral exposure to anti-oxidant glutathione could help prevent flu infections

...helial cells (the cells that line the mouth, upper airways and intestine). Scientists have found through studies in mice that viral infections result in oxidative responses that inactivate natural protease inhibitors, thus enhancing viral activation. They also have found that activation of the virus partic...

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