Researchers identify protein promoting vascular tumor growth
... because current therapies including steroids and alpha interferon have a number of high-risk side effect...nt, and cause weight gain and irritability. Use of alpha interferon as a medication in children can cause irreversible neurologic damage. Surgical removal is...New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
...inflammatory mediator called tumor necrosis factor alpha (TNFα). The result, published in the September 20, 2004 issue of the journal Cancer Cell, was increased effectiveness of a cancer-killing protein called TNF-related apoptosis-inducing ligand (TRAIL), leading to a decrease in cancer cells and in...New fruitfly model of diabetes has future implications for pancreatic cell transplantation
...produce a glucagon-like hormone, which are akin to alpha cells in mammals. These two cell types within the ...nome for genes that have a similar function in how alpha and beta cells develop. "This will be useful information for researchers trying to program und......with something like Compound 3, it would cause TNF alpha to trigger apoptosis in the cells that cause joint and tissue damage. Thus, the secondary inflammation from these cells would be prevented." However, he said, further studies in his laboratory will concentrate mainly on using Compound 3 as a prototy...Optimizing protein's 'death domain' halts leukemia in laboratory study
...that proved successful, it would show that the BH3 alpha helix and alpha helices from many other proteins could be used like keys to turn off protein activity involved in d...Body's own defense against H. pylori, cause of stomach ulcers and stomach cancer
...ns, called O-glycans, linked with the carbohydrate alpha 1,4-N-acetylglusoseamine, cloned previously in Dr. Fukuda's laboratory. Because the alpha 1,4-linked N-acetylgucosamine is confined to the stomach's deeper mucosa lining, which also lacks H....Other highlights in the June 16 JNCI
...molecules--matrix metalloproteinase 2 and integrin alpha v beta 3 --form a cell-surface trimolecular complex, cancer cells appear to become more invasive. Contact: Robert Kuska, National Institute of Dental and Craniofacial Research, 301-594-7560, kuskar@mail.nih.gov Also in the June 16 JNCI: Review:...Brain cells become more discriminating when they work together
... role in brain functioning. Since the discovery of alpha waves in 1929, experts have known that neurons in different parts of the brain periodically coordinate their activity with their neighbors. Despite a variety of theories, however, scientists have not been able to determine whether this "neuronal sync...Newborn lambs' central heating system could aid fat busting in humans
...cience Research section. "A further signal, PGC- 1 alpha is then needed to convert immature fat cells into ...o brown fat." To establish whether PPARs and PGC-1 alpha play a role in switching UCP-1 off the researchers looked at expression levels during late pregnancy...Lack of specific brain protein causes marked deficits in learning, memory
...evidence that lack of this protein known as RIM1 alpha causes profound deficits in the learning process...sing neurotransmitters. The mice lacking the RIM1 alpha protein, unlike the others, lacked the ability to learn the location of an escape platform in a poo...Gene variants may increase susceptibility to type 2 diabetes
...gion of a single gene, hepatocyte nuclear factor 4 alpha (HNF4A), a transcription factor that acts as a "master switch" regulating the expression of hundreds of other genes. HNF4A turns genes on and off in many tissues, including the liver and pancreas. In the beta cells of the pancreas, it influences th...JCI table of contents, March 1 2004
...siological significance of two proteins, I kappa B alpha and I kappa B beta, previously thought to possess ...ly controlled by two I kappa B proteins, I kappa B alpha and I kappa B beta, which prevent NF-kappa B from binding to DNA in the nucleus. Stimulation of NF-k...U Iowa study identifies damaging mechanism in transplants and heart attacks
...ry proteins. Two of these inhibitory proteins, IkB alpha and IkB beta, keep NF-kB in an inactive state. How... The UI team used gene manipulation to replace IkB alpha with IkB beta in mice. Mice with only IkB beta protein respond to bacterial infection in the same wa...PNNL recognized for commercializing technologies
...ds for the laboratory's Electrodynamic Ion Funnel, alpha particle immunotherapy for treating leukemia and s...y and surgery. Immunotherapy combines the power of alpha particle-emitting radioactive isotopes, such as actinium-225 and bismuth-213, with monoclonal antibo......nce to the nucleus due to the presence of importin alpha and beta. The researchers found that blocking this newly uncovered process inhibits nerve regeneration (photos available). The identification of the proteins containing the "healing message" and of the genes that enable the healing response is the n...Chimp vs. human DNA: what's in the 1% difference
...humans is caused by mutations to this gene, called alpha tectorin. Mutations in alpha tectorin result in poor frequency response of the ear, making it hard to understand speech. "It's so...Lifestyle accounts for difference in chimp, human genome
...humans is caused by mutations to this gene, called alpha tectorin. Mutations in alpha tectorin result in poor frequency response of the ear, making it hard to understand speech. "It's so...Novel therapies show promise against myeloid leukemia
... leukemia in blast crisis, MSC-produced interferon alpha (IFNaMSC) inhibited tumor growth in vivo and doubl... apoptosis (cell death) and degradation of PML-RAR alpha oncoprotein and this synergy might provide a plausible explanation for superior efficacy. Side effe...Zadaxin in triple therapy shows 61% response for hepatitis C non-responders
...IN® in combination with pegylated interferon alpha and ribavirin produced a 12-week early virologic r...rate recent studies show that pegylated interferon alpha plus ribavirin produce an EVR in approximately 15-21% of non-responders and a sustained viral respon......The newly activated spores are then bombarded with alpha particles, a form of radioactivity that does not penetrate skin or clothes. The alpha particles kill the spores, rendering them nontoxic. Carl Czajkowski, a Brookhaven Lab scientist, an...