Wolves decline, moose increase
...and the Chippewa Harbor pack, with the east pack's alpha male killed. Peterson's team found that particular wolf, one of four on the island wearing a radio collar, just offshore in Lake Superior. "The Chippewa Harbor pack has been pushing the east pack aside and enlarging their territory," Peterson said. "...MGH researchers unravel structure of a key protein involved in tumor angiogenesis and metastasis
... supply to grow. A key receptor protein called the alpha V beta 3 integrin directs formation of new blood v..." says Arnaout. The MGH scientists also found that alpha V beta 3 integrin changes its shape when bound to its ligand, allowing it to send chemical signals i......o study. GNAS1 (guanine nucleotide binding protein alpha stimulating activity polypeptide) provides the DNA blueprint for Gs-alpha, a protein that plays a critical role in a cell's ability to respond to its external environment. Part of an elegantly complex metabolic system called a signal transduction pat...Enzyme mimetic reduces tissue damage in colitis animal study
... pro-inflammatory cytokines, tumor necrosis factor alpha (TNF-) and interleukin-1 (IL-1), implicated in the development of inflammatory bowel disease. M40403 is one of a proprietary family of small-molecule SOD mimetics developed by MetaPhore that are designed to selectively remove superoxide, a free rad...Low doses of radiation in nature may pose more risk
...researchers found the bystander effect occurs with alpha particles, a common type of radiation that comes f...tute-funded study, the researchers beamed a single alpha particle through the nuclei of randomly selected cells growing in petri dishes. Alpha particles cons...Science: nanoscale 'Trojan Horse' attacks cancer cells from within
...Inside the cell, the actinium decays by giving off alpha particles--very small, high-energy particles that ...hree "daughter" atoms, each of which emits its own alpha particle as well. "These are extraordinarily potent drugs. One atom will kill a cell," says Scheinbe......search in Dallas have linked abnormal secretion of alpha interferon to the malfunctioning immune systems of...ients as the dendritic cells are hyperactivated by alpha interferon, one of three main classes of specialized protein weapons activated in the bodys otherwis......t was completely resistant to prior treatment with alpha interferon given with or without a second antivira... always detectable in blood despite treatment with alpha interferon. Within 48 hours of the initiation of treatment with omega interferon,HCV RNA fell sharp...Experiments offer major clue to repairing diseased nerves
...ne responsible for producing tumor necrosis factor alpha and then bred successive generations of the rodent...ical trials of several drugs designed to block the alpha form of TNF, which was considered to be a problem, actually made patients conditions worse, Arnett s...Drugs from sea study finds sponge health link to bacteria
... newly discovered bacterial strain (of the family, alpha Proteobacteria, very common to coastal waters) is also somewhat of a scientific departure. Previous cultivation studies of such bacterial-sponge associations showed that bacterial populations in sponges could be very diverse. "This provides an excel...Biologists discover protein's impace on plant-water balance
...in component within the guard cells, the G-protein alpha subunit, had been eliminated. The Penn State group analyzed those plants and found that they had lost a typical response to ABA regulation of the guard cells. As a result, opening of the stomatal pores was no longer inhibited by ABA and water loss ...Quick, easy, color-coded technique will speed identification of drugs for diseases
... colleagues created analog proteins that mimic the alpha and beta forms and tagged them with fluorescent pr... known as cyclic AMP (cAMP), the researchers added alpha and beta analogs to the genome of the amoeba and then exposed the cells to cAMP. When the GPCR was i...Treatment in mice proves effective against Duchenne muscular dystrophy
...fmans lab discovered the molecule in question the alpha 7 integrin in 1985. A deficiency of this molecul...d they engineered them to produce even more of the alpha 7 integrin protein. Untreated mice developed debilitating muscular dystrophy, suffered severe weigh...Novel protein is both ion channel and enzyme
...kinase itself is a member of a unique class called alpha kinases because they phosphorylate alpha helices in proteins. While the mechanism of the action of TRP-PLIK is known, its biological functio...Researchers find candidate gene for premature menopause
...e premature menopause. They found that the inhibin alpha gene (one of three inhibin genes) was mutated in t...menopause. "We think that mutations in the inhibin alpha gene may be responsible for premature menopause in very young women, but that more subtle changes in...Researchers zero in on first drug that may be helpful in treating common liver disease
...the drug had lower levels of tumor necrosis factor alpha (TNF alpha) in their livers than those who had not. TNF alpha is a protein produced by the body during inflammation. It also promotes insulin-resistance. The sci......rd post-surgical treatment for Stage III melanoma, alpha interferon." Berd added, "It is important to note ...multi-center randomized trial comparing M-Vax with alpha interferon. We believe that the confirmation of our earlier findings, showing the relationship betw...Estrogen may fuel lung cancer growth, report University of Pittsburgh scientists
... study looked at two common estrogen receptors (ER alpha and ER beta) on lung cancer cell lines, cultured normal lung cells and normal and tumor tissues from lung cancer patients. The researchers found that normal lung tissue rarely showed detectable levels of ER alpha, whereas lung tumor cells ha...Understanding how the first cells emerged
...ith a membrane, however, the protein folds into an alpha helix. According to the computer simulation, four of these helices then bond to each other, forming a channel on the inside, and the whole package inserts itself into the membrane to escape the water. Within the channel, parts of the proteins bond t......ense of smell, that person may barely perceive the alpha pinen (the active chemical responsible for the smell). This means that the rest of the consumers will think it smells too piney," said Friedrich. "That's a problem." Using a selective and sensitive bioassay for smells based on gas chromatography ol...