Gene expression patterns may help predict risk and progression of prostate cancer
...the prostate gland containing cancer, meaning some alteration has occurred throughout the prostate tissue. This study lends support for such a hypothesis." The researchers also created a gene model using GeneSpringTM software to predict the aggressiveness of the disease and found that the expression prof...Researchers identify gene for a primary form of sudden infant death sydrome (SIDS)
... disease that has never been described before. The alteration in TSPYL can affect the neurological system and cause sudden death, and in males can also affect the reproductive system. According to Stephan, the relationship of TSPYL mutations or polymorphisms to SIDS in the general population will be studied nex...Scientists suggest framework for epigenetics in common disease
...hen the mutation can't cause disease. More subtly, alteration of epigenetic marks could "tune" gene expression to cause a full spectrum of effects. Epigenetic variation is also likely to help relate environment and age to disease incidence and risk, the researchers say. "Common complex diseases occur more often...New understanding of the machinery of flinching
...effects on the polysensory zone were partly due to alteration of the muscle response as well as to effects on the sensory response to the air puff. The researchers concluded that their findings help reveal the role of the polysensory zone (PZ) as a "hotspot" that is relatively specialized for processing a parti...Heart gene yields insights into evolution, disease risk
...regulatory region of the gene. However, the single alteration in the MMP3 protein regulatory region causes a functional difference that has important clinical implications. The MMP3 protein is an enzyme that plays a role in regulating the elasticity and thickness of blood vessels. While its effects are complex,...Growth hormone and IBD: Reduction of intestinal inflammation, promotion of growth
...n associated with increased SHP2:gp130 binding and alteration in CEC and LPMC apoptosis and proliferation. The results indicate that use of growth hormone in IBD would lead to new therapeutic approaches taking advantage of improving growth and intestinal healing....