Researchers design and build first artificial protein
... colleagues took advantage of methods for sampling alternative protein structures that they have been developing for some time as part of the Rosetta ab initio protein structure prediction methodology. "Indeed, the integration of protein design algorithms (to identify low energy amino acid sequences for a fixe...New drug target and biomarker for advanced childhood cancer discovered
... in cancer patients for whom there currently is no alternative therapy....Advance in developing biological strategies to produce hydrogen and sequester carbon dioxide
...lopment of new methods for carbon sequestration or alternative energy production. "This research is a next logical step in the efforts to understand the key elements that comprise a biological system," Secretary Abraham said. "This is a major goal of the biological research carried on by the Nation's major publ...Technique may identify novel disease genes at a faster clip
...ion of Nova, an RNA-binding protein that regulates alternative splicing. In alternative splicing, messenger RNA, carrying the blueprint for a protein from the cell's genes, is processed in...Researchers describe new technique for cataloging RNA targets in rare brain disease
...in called Nova plays a critical role in regulating alternative splicing within the brain. "We have developed and ...a mature mRNA that codes for cellular proteins. In alternative splicing, different pieces of this pre-mRNA, called exons, are stitched together to produce differen......rnal subscriptions stimulated the need to seek out alternative publishing models. Tom Sanville, Executive Director of OhioLINK, explains the commitment by OhioLINK to fund open access publishing for all 84 member institutions: "We need economically sustainable access to quality research. We want to give our fac...NHGRI selects sequencing centers
...ommunity to carefully consider and discuss all the alternative targets that could be sequenced to address the goals of our institute, and then select the best target for the purpose," said Dr. Peterson, who is also program director for the NHGRI's Large-Scale Sequencing Research Network. After evaluating the re...DuPont awarded highest US honor for technological innovation
...rators. The first-developed and most widely used alternative to date was hydrochlorofluorocarbon (HCFC) 22. While less ozone-depleting than CFCs, HCFCs are governed under the Montreal Protocol and are being phased out globally. DuPont commercialized the first of its non-ozone-depleting hydroclorofluorocarbo...President Bush to present DuPont with National Medal of Technology
...its global leadership and innovation in developing alternative technology that reduced the environmental impact caused by ozone-depleting chlorofluorocarbons (CFCs). DuPont Chairman and CEO Charles O. Holliday, Jr. will accept the Medal from President Bush at a White House ceremony Thursday, Nov. 6 at 3 p.m. Du...Hot cocoa tops red wine and tea in antioxidants; may be healthier choice
...the health benefits of cocoa and points to a tasty alternative in the quest to maintain a diet rich in healthy antioxidants, chemicals that have been shown to fight cancer, heart disease and aging, the researchers say. Their study, which they say is the most complete comparison to date of the total antioxidant c...Researchers home in on obesity gene and offer explanation for overeating
...t adults in France, from which they identified two alternative forms, or alleles, of the GAD2 gene. One form of the gene was found to be protective against obesity, while another increased the risk of obesity. The normal weight group of French adults had a higher frequency of the protective form of the GAD2 ge...Gene controls age at onset of Alzheimer's and Parkinson's diseases
...urological disorders are of particular interest as alternative targets for treatment, said Margaret Pericak-Vance, Ph.D., director of the Duke Center for Human Genetics. Drugs that delay the onset of Alzheimer's or Parkinson's diseases beyond the normal human lifespan would effectively prevent them in patients a...JCI table of contents, 15 October, 2003
...ergy and Immunology in California found that in an alternative mouse model of lupus, treatment with alphaGalCer caused an abnormal Th1-type immune response that in fact exacerbated disease. Treatment with blocking anti-Cd1d monoclonal antibodies augmented the immune response and ameliorated disease. In their rep...Cow's resistance to worms is genetically determined
...he development of a vaccine, which would be a good alternative for preventing gastrointestinal worm infections....Using plants and microbes to purify polluted industrial wastewater
...uthorities accept constructed wetlands as a viable alternative to conventional wastewater treatment. As a non-bureaucratic network linking research and the private sector, EUREKA is easy to work with, and has raised the recognition of results at local and national level."...DuPont and NREL to develop world's first integrated 'bio-refinery'
...nd demonstrate the feasibility and practicality of alternative energy and renewable resource technology. The initiative will develop the world's first fully integrated bio-refinery, which will be capable of producing a range of products from a variety of plant-material feedstocks. Several bio-refineries curren...UCSD researchers find promising new avenues for treating infections
... cells in the hope that such insight would lead to alternative treatments for the infections. "We knew that these bacteria use a needle-like structure to inject toxin directly into mammalian cells," explains Ghosh. "But we didn't know the mechanism by which the toxin induced cell death." Three of their finding...Thorough, searchable database of human proteins unveiled
...get a single entry that contains everything -- its alternative names, structure, function and sequence, how it's modified, other proteins with which it interacts, where it's found in cells, where it's found in the body and links to the papers that say so. "The richness of the database is astounding, since it...Does a new hypothesis help explain higher levels of hypertension among African-Americans?
...emature development of essential hypertension. An alternative to this widely accepted approach is the "pressure natriuresis" hypothesis. It supposes that stress-induced impaired sodium (salt) regulation leads to an extended period of elevated BP in blacks, and that the resulting increase in BP load leads to the...NIH announces strategy to accelerate medical research progress
...age scientists and scientific institutions to test alternative models for conducting research. Implementation groups in this area are: High-Risk Research-NIH Director's Innovator Award Interdisciplinary Research Public-Private Partnerships "Biological, physical and information sciences have converge...