Duke Researchers Show "Editing" Can Fix Faulty Genes In New Approach To Gene Therapy
...of these newtherapeutic approaches for sickle cell anemia and even to "sabotage"the AIDS virus. "This research proves that we can use nature's ownprocesses to rewrite genetic instructions in mammalian cells," Sullengersaid in an interview. "The results have encouraged us to go forwardin exploring the use o...Low Iron Levels Cause Weakness In Women Who Are Not Anemic
...7, Haas has been looking at iron depletion without anemia in several groups of women, ages 19 to 36. Their ...vide mounting evidence that iron depletion without anemia should be a concern. Other researchers have recently reported that moderate iron deficiency also c...Iron Deficiency Increases Likelihood Of Bone Fractures
...ros. “And given the fact that iron deficiency anemia is so common, it’sremarkable that nobody examined the connection between iron and healthybones before.” The researchers fed some laboratory rats a healthy diet, while otherrats ate a diet deficient in either iron or copper. X-rays of......he same protein is responsible for iron-deficiency anemia in twodifferent animal models. All cells in the body require iron to function, but the details of ironmetabolism, particularly which proteins are specifically responsible for ironabsorption in the intestine and iron traffic within cel...Fortified Drink Improves Third World Nutrition
...nkers, most of the children with moderately severe anemia showed significant improvement in iron status. But many of the nonfortified drinkers showed a reduction. For vitamin A, only 11 percent of the fortified children were still below the benchmark for serum retinol levels, compared with 20 percent of ...... cutoffs at this age. Infants at greatest risk for anemia and low ferritin were those with birth weights 3000 g had a low ferritin value at 6 mo. We conclude that the risk of iron deficiency is low among infants with birth weights > 3000 g who are exclusively breast-fed for 6 mo. Iron drops ...Health Effects Of Consuming Alcohol, Dairy Foods, And Iron-Fortified Products ToBe Debated
...th claim for dairy foods. Iron deficiency anemia is the most prevalent nutritional disorder in theworld, affecting a billion people, mostly women and children. "IronFortification of Foods" (Session F-3, June 21, 1:30 PM) will show thatfortifying commonly eaten foods with iron is one of the least e...Duke Researchers Call Gene Therapy A Promising Strategy For Sickle Cell Anemia
... Therapies, tried their new therapy on sickle cell anemia because thereis no effective treatment for the und...micResearch Fund grant to Lee. Sickle cell anemia is an inherited disease that is most common amongpeople whose ancestors come from Africa and the Mid...Largest Generation Of Adolescents Faces Reproductive Health Risks
...ks, such as pregnancy-induced high blood pressure, anemia andhemorrhage, obstructed and prolonged labor, and postpartum infection. Althoughthese ailments can occur at any age, they are often more pronounced and moredangerous in very young adolescents. Laurie Schwab Zabin is Professor, Department of Populat...Treating Anemia Reduces Risk Of Death For People With HIV
... World AIDSConference inGeneva show that untreated anemia alone can significantly increase the risk ofdeath ...d physicians alike need torecognize thesymptoms of anemia early and treat it." Anemia, marked by a depleted number of red blood cells that carry oxygen t...UNC Scientists Succeed In Inserting Gene In Human Cells Via Artificial Chromosome
...uch as hemophilia, cystic fibrosis and sickle cell anemia and improvetreatment. "We have been able to do this with a piece of DNA five to 20 times theusual size scientists work with," said Dr. Jean Michel Vos, associate professorof biochemistry at the UNC-CH School of Medicine. "Although so far we h...Gene Therapy Trial Approved For Rare Anemia
...to Walsh, the majority of individuals with Fanconi anemia are unawarethey have the disease. "By and large, m...thy blood cells that are needed every day. Fanconi anemia affects an estimated 2,000 to 3,000 people in the United Statesand Europe. Given these relatively sm......r supplements. While many cases of iron-deficiency anemia occur as a result of inadequate dietor blood loss,... our gene was important, given the iron deficiency anemia themutation caused, but determining the similarity to ceruloplasmin gives us a cluethat this protein......p C) ofthe feline leukemia virus that causes fatal anemia in domestic cats, and fortype D primate retroviruses, a family of viruses that cause severeimmunodeficiencies in primates and that have been found in numerous AIDSpatients, particularly in Africa. Results of those studies are awaitingpublication....Dietary Vitamin A Supplements Improve Maternal Survival In South Asia
...fective way to preventmaternal iron deficiency and anemia in the developing world. "The study findings indicate that an adequate dietary intake of vitaminA (or beta-carotene) may complement efforts to provide prenatal and obstetriccare to improve maternal survival in the developing world," said Dr....Genetic Mutations Linked To Rare Metabolic Disease
...tics. Called megaloblastic anemia 1, or Imerslund-Grasbeck sy... This work on the genetic cause of megaloblastic anemia 1was helped by the fact that it is more prevalent in Finland. ...Fortified Drink For Pregnant, Lactating Women
...drink, most of the children with moderately severe anemia showedsignificant improvement in iron levels while many of the consumers of thenonfortified drink showed a worsening. Latham notes that between one- and two-thirds of pregnant women in thedeveloping world suffer from anemia, and many do not take iro...Jefferson scientists further develop gene repair technique
...ogy mayhold promise as a treatment for sickle cell anemia and other diseases bycorrecting the DNA mutation f...will move ustoward cystic fibrosis and sickle cell anemia applications."...Target for cystic fibrosis drugs found
...CF was a "folding disease" -- much likesickle cell anemia -- and struck on the idea of fixing the problem bycorrectly folding the mutant protein. In work yet to be published, Ko used an unlikely molecule -- heavy water --to fix the mutant CFTR fragment. The heavy water acts like an extra set ofhands on the ......he amelioration of human diseases like sickle cell anemia and Crigler-NijjarSyndrome. Arntzen believes the new technology "would be used to benefit farmers and foodproducers. We may one day be able to quickly reduce caffeine in coffee beans orshorten the long-chain fatty acids found in plants like soybea...