Researchers identify protein promoting vascular tumor growth
...ited in these cases make free radicals and promote angiogenesis that is beneficial in the wound-healing process. ...-being of people with tumors." Because angiogenesis is implicated in the development of other kinds of tumors and chronic inflammatory conditions, OSU s...16th EORTC NCI AACR Symposium 'Molecular Targets and Cancer Therapeutics'
.... * Dr. Olivier Feron: A revolutionary approach to angiogenesis - exploiting tumour blood vessels to boost chemotherapy and radiotherapy instead of (or before) killing them. Successful mouse study leads to patient trial. * Professor Eric Van Cutsem: International trial results shows way to measure success of cent...IBD (Crohn's, Colitis) 'joins' cancer, inflammatory diseases in associated blood vessel growth
...e. Relatively recently, a novel pathogenic role of angiogenesis has been established for such chronic inflammatory...aterial and conceptual framework for investigating angiogenesis in IBD both as a pathogenic component as well as a possible therapeutic target," he added. Method...Zoledronic acid zings cervical cancer
...ervical cancer to explore the molecular control of angiogenesis in cancer progression, Douglas Hanahan and colleag...edronic acid treatment in the mouse model impaired angiogenesis and slowed cervical tumor progression and growth. The researchers showed that this drug acted by bot...JCI table of contents: 1 September, 2004
...ervical cancer to explore the molecular control of angiogenesis in cancer progression, Douglas Hanahan and colleag...edronic acid treatment in the mouse model impaired angiogenesis and slowed cervical tumor progression and growth. The researchers showed that this drug acted by bot...Advances in tumor angiogenesis Dendritic cells co-opted to the dark side
... between factors that promote tumor growth such as angiogenesis and factors that control tumor growth such as immu... Thus, VEGF promotes tumor growth not only through angiogenesis but also through suppression of antitumor immune response, because these dendritic cells lose their ...New compound could give some types of cancer the one-two punch
...t toxic effect on cancer cells, and also prevented angiogenesis the formation of new blood vessels from pre-existing ones," said Tom Li, the study's lead investigator and an associate professor of pharmacy at Ohio State. "It's like using one stone to kill two birds." Li presented the results on August 22 in Phil...JCI table of contents, 2 August, 2004
...CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model AUTHOR CONTACT: Akihiko Taguchi National Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan Phone: 81-6-6833-5012; Fax: 81-6-6872-7485; E-mail: ataguchi@res.ncvc.go.jp View the PDF of this article at: https...Scientists identify molecular link driving spread of skin cancer
...hetic peptides to reduce tumor cell metastasis and angiogenesis and increase apoptosis may be important in the development of therapeutics for malignancy," said Hynda Kleinman, Ph.D., chief, cell biology section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Md. ...New compound 'highly efficacious' at reducing human tumour growth
... Austria: Treatment with a new dual cell cycle and angiogenesis pathway inhibitor blocks VEGF-induced vascular permeability, inhibits tumour angiogenesis and induces apoptosis in human tumour models said Dr. Gerhard Siemeister of Schering AG, Corporate R...Endometriosis: Could angiostatic therapy be the new treatment of the future?
...d a new therapeutic strategy. Endostatin or other angiogenesis inhibitors could be one of these approaches."...Other highlights in the June 16 JNCI
...lpha, a subunit of HIF-1, is associated with tumor angiogenesis and tumor cell proliferation. Lee M. Ellis, M.D., ...ts of inhibiting HIF-1alpha on VEGF expression and angiogenesis and tumor growth in human gastric cancer. They found that inhibition of HIF-1alpha activity decreas...JCI table of contents, 15 June 2004
... healing. TITLE: Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction AUTHOR CONTACT: Albert J. Sinusas Yale University School of Medicine, New Haven, Connecticut, USA. Phone: (203) 785-4915; Fax: (203) 737-1026; E-mail: albert.sinusas@yale.edu View the PDF of this article...UNC scientists uncover crucial mechanism for blood vessel development
... Growth Factor-A, or VEGFA, said Bautch. Sprouting angiogenesis occurs as a result of the interactions of VEGFA with two cell receptor molecules, VEGFR1 (also called flt-1) and VEGFR2 (also called flk-1), she added. While flk-1 is thought to promote endothelial cell division, the exact functions of flt-1 are poo...Drug that cuts off tumor's blood supply extends lives of colorectal cancer patients
...England Journal of Medicine. The study paired the angiogenesis inhibitor Avastin, approved by the U.S. Food and D...articular," Kabbinavar said. "Avastin is the first angiogenesis inhibitor to be approved by the FDA, and we found it has manageable toxicity. So patients not only l...Other highlights in the May 5 JNCI
... proliferation and migration in vitro , inhibited angiogenesis in rat corneas, and inhibited solid melanoma growth in mice. In an editorial that accompanies the article, Judah Folkman, M.D., of Children's Hospital in Boston, writes, "DNAzymes targeting c-Jun could act as both direct and indirect inhibitors of an...New approach offers potential drug-discovery shortcut
...that GS4012 appears to promote the activity of the angiogenesis factor VEGF and also induces the development of vascular networks in cultured human vascular cells. "We had a strain of fish with a very specific arterial defect, and although we knew which gene was responsible, there was a lot we didn't know about...JCI table of contents, 2 April 2004
...ranscription-controlled gene therapy against tumor angiogenesis AUTHOR CONTACT: Dror Harats Sheba Medical Center, Tel Hashomer, Israel Phone: 972-3-530-2940 Fax: 972-3-534-3521 E-mail: dharats@post.tau.ac.il View the PDF of this article at: https://www.the-jci.org/press/20007.pdf Possibilities from the Imp...Fox Chase Cancer Center research reveals how COX-2 causes ovarian cancer
...so been shown to stimulate tumor cell division and angiogenesis (new blood vessel formation) and to inhibit a type of programmed cell death called apoptosis, which helps control the growth of tumors. Xu's analysis of the ovarian tissue specimens showed that as the level of COX-2 increases, it appears to promote ......determines a threshold between normal and aberrant angiogenesis AUTHOR CONTACT: Helen Blau Stanford University School of Medicine, Stanford, California, USA. Phone: 650-723-6209 Fax: 650-736-0080 E-mail: hblau@stanford.edu View the PDF of this article at: https://www.the-jci.org/press/18420.pdf *************...