IBD (Crohn's, Colitis) 'joins' cancer, inflammatory diseases in associated blood vessel growth
...an activated profile as shown by the expression of angiogenic marker V3 integrin. "Targeting this integrin could...GF. Finally, IBD-derived extracts induced a potent angiogenic response in the corneal assay compared to control-derived extracts, they noted. Conclusion The res...Newly designed nanoparticle quantum dots simultaneously target and image prostate tumors in mice
...d vessels in a process called angiogenesis. These angiogenic vessels are very porous, which allowed the quantum dots to leak out and accumulate at the tumor sites, where they could be detected by fluorescence imaging. The scientists then conjugated the quantum dots to a highly specific monoclonal antibody tar...UNC scientists uncover crucial mechanism for blood vessel development
...ulation in the limbs and extremities." The goal of angiogenic therapy in these situations is to restore circulation non-surgically. "There have been attempts to induce blood vessel formation by manipulating the VEGF molecular pathway. Most of the time you don't get functional vessels, but a set of dilated vesse...Other Highlights in the June 2 JNCI
...d., and colleagues show how estrogen may act as an angiogenic switch and allow progression of breast carcinoma. Contact: Susan Johnson, National Institute of Dental and Craniofacial Research, National Institutes of Health, 301-496-4260, johnsonS@od31.nidr.nih.gov Zoledronic Acid Treatment Benefits Men with M...UNC researchers identify virus gene involved in tumor cell growth, spread
...t cell types, Damania said. Kaposi's sarcoma is an angiogenic tumor, meaning that the tumor can recruit blood vessels to the tumor site, and the sarcoma is also known to metastasize. Damania's research team investigated the action of K1 in blood vessel endothelial cells and skin epithelial cells. "We observed t...JCI table of contents, 2 April 2004
...ch microenvironments, such as those found in tumor angiogenic vessels. The transgene produces a receptor that, upon activation by TNF-_, initiates the Fas-induced apoptotic pathway. Treatment of two tumor mouse models resulted in tumor growth rate reduction and decreased tumor size. Histology revealed that EC a...Possible link discovered between gene responsible for blood vessel development and ACD in newborns
... know from past research that eNOS is required for angiogenic genes to produce new blood vessels in the heart and elsewhere," says Dr. Stewart. Results of this study show that eNOS also plays a previously unrecognized role in lung development. "This is an exciting discovery as it is the first insight into the g...Study demonstrates altered angiogenic proteins in preeclampsia patients
...hat preeclampsia is actually an exacerbation of an angiogenic state that has been noted at term in normal pregnancies," explains Karumanchi. "The angiogenic 'brakes' are being applied too hard and too soon, resulting in an exaggeration of the normal process...JCI Table of Contents, January 15 2004
... Vascularization of this maturing tissue relies on angiogenic recruitment from surrounding vessels. The growth f...l bone vascularization and is now implicated as an angiogenic factor for epiphyseal vascularization. By generating mice that express specific splice forms of VEGF...JCI table of contents, January 2, 2004
... Vascularization of this maturing tissue relies on angiogenic recruitment from surrounding vessels. The growth f...l bone vascularization and is now implicated as an angiogenic factor for epiphyseal vascularization. By generating mice that express specific splice forms of VEGF...Scientists report on promising new approaches to induce cancer cell suicide
...of molecular and gene therapy tricks to convert an angiogenic protein used by tumors to promote their growth int...process called tumor angiogenesis, by secreting an angiogenic growth factor called VEGF. Researchers from the University of California, San Francisco today prese...Clock cells, tumor suicide, tailored therapies among subjects of AACR-NCI-EORTC Conference
...ndothelial growth factor (VEGF) from a promoter of angiogenic growth and survival to a cancer killer. One study shows that binding VEGF to the Fas apoptosis receptor, creating VEGFR2Fas, triggers the signal for cell death. Further investigation will seek to optimize this effect and determine the feasibility o...Research finds tumor preventive qualities, damage reversal, in green tea
...d in the D-ring, inhibits expression of the potent angiogenic factor VEGF (vascular endothelial growth factor) in breast cancer cells, similar to EGCG. "These analogs are not only valuable tools to clarify how green tea may fight cancer, but are also potential chemopreventive drug candidates themselves, with p...Drug developed for rare disease may help millions more as treatment for cancer, autoimmune diseases
...h the same way that copper deficiency inhibits the angiogenic effect in tumor cells, Brewer found it also inhibits transforming growth factor beta, or TGF-beta, the response that triggers the connective tissue growth. Additionally, studies suggest TM inhibits TNF-alpha, or tumor necrosis factor alpha, the respo...UNC studies identify key genes involved in blood vessel development
...or vascular endothelial growth factor, which is an angiogenic factor," Patterson said. "But it's also important to us because it's the first gene that gets turned on in endothelial progenitor cells. So we wanted to know what transcription factors turn on flk1 and are those factors themselves sufficient enough t...Animal studies show CA4P suppresses development and induces regression of ocular neovascularization
...suggests that when administered before onset of an angiogenic stimulus, CA-4-P can prevent these two forms of ocular neovascularization. A recent study has shown that CA-4-P can also prevent ischemia-induced retinal neovascularization in mice. Therefore, CA-4-P joins a growing list of drugs that have potentia...New compound class found to trigger changes in cell garbage can
...werful agents for inducing vessel growth and their angiogenic activity correlates with their ability to interac...aster switch genes that activate several different angiogenic cascades. These peptides also prevent degradation of a molecule that normally inhibits activity of...JCI table of contents, July 1 2003
...issue function in two models muscle ischemia. This angiogenic matrix protein Del-1 may be a useful tool for the therapy of ischemic disease. TITLE: Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1 AUTHOR CONTACT: Judith A. Varner University of California, San Die...JCI table of contents, 2 June, 2003
...fense, would healing, and tissue repair. TITLE: An angiogenic role for the human peptide antibiotic LL-37/hCAP-18 AUTHOR CONTACT: Robert Bals Hospital of the University of Marburg, Marburg, Germany. Phone: 49- 0-6421-2866451 Fax: 49-0-6421 2868987 Email: bals@mailer.uni-marburg.de View the PDF of this article...Radiation therapy targets cancer cells on two fronts, Science study says
... blood vessels is called angiogenesis. "When the angiogenic blood vessels are damaged, the death of tumor cells results," said Kolesnick. To date, most radiation therapy research and clinical regimens have targeted the tumor cells themselves. However, the authors say that the field is ready for a paradigm s...