Prostate Cancer Switch May Yield Map Of Cancer Machinery, Targets For Drugs
...that governs whether a cancer cellgenerates one or another form of a protein receptor molecule called FGF-R2(... fits a protein called a growthfactor, secreted by another cell in the prostate. As long as the FGF-R2 receptoris of one type -- called IIIb -- the cancer cell...RNA-Dendritic Cell Combo Shows Promise As A Universal Cancer Vaccine
...eral Food and Drug Administrationapproval to start another phase 1 trial, using RNA extracted from colon cancercells. The Duke cancer vaccine harnesses two biological powerhouses: thepotency of rare immune cells, called dendritic cells, whose job it is seek outforeign tissue and alert the immune syst...Chromosomal Abnormalities Key For Prediting Leukemia Outcome
...icationtherapy. Stem-cell transplantation is another line of therapy available to AMLpatients whose disease doesn’t respond well to chemotherapy. A patient’s cytogenetics helps determine treatment by identifyingthe subtypes of leukemia that are likely to respond to a certain type ofther...Liquid Crystals Light Up Simple Chemical Test
...there," he said. His current idea is to construct another landscape. This one would consistof a patchwork of fields, each field studded with a different density ofmolecular receptors. The test result would appear as a grid of bright anddark squares that would tell the user how much of the targeted materialw...Caribbean Lizards Evolve Independently
...emely short legs andcrawls slowly on narrow twigs; another has long legs and runs rapidly on theground; a third lives in the grass. Moreover, species that live high in thetrees tend to have big toepads, important for clinging, whereas those that aremore terrestrial have small toepads. The interesting thing...Pitt Researchers Develop Strategy To Use Dendritic Cells To Treat And Prevent Tumors
...findings were observed when researchers vaccinated another setof mice with established tumors using DC's that were simply co-cultured withtumor cells. In contrast, control mice that were injected with either DC'salone or a mixture of DC's and tumor cells that weren't previously co-cultureddeveloped tumors a...Butterfly Wings, Beetle Horns Teach Biologists Basic Lesson In Development's Laws
...orrespondingly enlargedcompound eyes. In another set of beetle experiments, the researchers selecti...ng largely developed through natural selection and another and adjoining partbeing reduced by this same process ...., and on the other hand, the actualwithdraw...Molecular Defect Could Be Mysterious Cause Of Blood Disorder
... were exposed toeither thrombopoietin or thrombin, another platelet activating factor, and thenanalyzed for the expected responses and protein expression. Platelets from normal subjects, when exposed to thrombopoietin, producedthe correct signals and expressed a normal thrombopoietin receptor. Byco...New Test Opens Window On Corrosive Free-Radical Activity In Individuals
... were shown effective in lowering those levels. In another study,8-epi-PGF2alpha was found to be elevated during the critical period ofreperfusion after bypass surgery or treatment for a heart attack. In a report published in the October 15 issue of the Journal of ClinicalInvestigation, high levels o...Common Mutations Linked To Increased Risk Of Breast Cancer
...lgroup," Dr.Helzlsouer said, "but we can't be sure another risk factor isn'taffecting our results until researchers can study these connections in a muchlarger group of patients." This research was funded by several grants from the National Institutesof Health, including the National Cancer Institute...Can The Economic Promise Of Drug Discovery Continue To Preserve The Suriname Forest?
... made not to develop them asantifungal agents. In another example, graduate student John Berger has beenable to enhance the anticancer activity of a new compound by synthesizinganalogs, reports Kingston. "Now we're looking for others with more activity fromwhich we can make analogs." Meanwhile, Bris...Researchers Discover Ways The Ulcer/Cancer Bug Can Trigger Disease
...ning," Falk says. In 1993, Falk and another Swedish scientist at Washington University,Thomas Born, D.D.S., Ph.D., discovered that H. pylori can attach to a moleculecalled Lewis b (Leb) on stomach lining cells. This molecule also decorates thered blood cells of people with the Leb blood group....Kaposi's Sarcoma Caused By Virus Usually Transmitted Through Homosexual Sex, According To UCSF Study
... you're in trouble." "Our findings are yet another example of the rich source of data thatare provided by long-term population-based epidemiologic studies of this kind,"says Dennis Osmond, PhD, UCSF associate professor of epidemiology andbiostatistics, the principal investigator of the Men's Health S...Echocardiography Is Effective In Measuring Microvascular Damage From Heart Attacks
... a patientat risk for later complications, such as another heart attack, congestive heartfailure or stroke. Researchers compared CE to MRI by blocking coronary arteries in animalmodels for 90 minutes to simulate a heart attack. Then they observed the returnof blood flow two days and nine days later ...MSU Scientists Eavesdrop On Bacterial
.... When they break away from thecolony they undergo another biochemical change and revert back to theplanktonic, free floating type. "But there still was one unanswerable question: How could they have sucha complex [biofilm] structure without cell-cell signaling," said Bill Costerton,who heads the MS...Scientists Seek Early Warning Of Drinking Water Threats
...'s team will take a forward-looking view: Is there another emergingpathogen on the horizon that could unexpectedly threaten public health, in thesame way crypto has in the past decade? "Cryptosporidium is not the only microorganism of concern in drinking water,"says Battigelli. "Although crypto has been the ...New Sunspot Cycle To Be Bigger Than Average
...es) to trends in solar activity, as outlined in another paper by Wilson for the Journal of Geophysical Research (Atmospheres) . Still, with almost 250 years of observations - of which only the last 150 years are considered truly reliable- predictions are akin to the Farmer's Almanac, Hathaw...Purdue Finding May Snuff Out The Sniffles
...to bind to white blood cells, and binds instead to another part of the receptor to gain entry into the cell, says Jordi Bella, a postdoctoral researcher working with Rossmann on the study. "Our study shows that the very tip of the ICAM-1 molecule is shaped somewhat like a hand, with a thumb and three project......ith overheated circuits and remote capability. Yet another advantage of the proposed system, he said, is that whereas humanscan only see light in the visible portion of the spectrum, the optoelectronicsensor will be able to convert any wavelength of light into usable information. For practical purposes, this......irantiviral action was amplified. Macrophages are another type of immune-systemcell and play a role in increasing CD8+ cell function. While this study was the first to show that macrophages are involved inthis CD8+ and HIV response, the observation was not unexpected, as macrophagesare known to be i...