JCI table of contents, March 1 2004
...brogenic activity could be blocked by neutralizing anti TGF-beta1 antibodies confirming that TGF-beta1 is directly involved in bone marrow fibrosis in HCL. The report also suggests that the levels of circulating TGF-beta1 should be considered as a non-invasive indicator for the ongoing fibrogenic processe...Imperial researchers show novel flu treatment eliminates symptoms in mice
...that try to predict how the virus might mutate, or anti viral drugs that must be administered as soon as there is contact with the virus, this new treatment can be given after symptoms present. Dr Tracy Hussell of Imperial's Centre for Molecular Microbiology and Infection and senior author of the paper, s...Critical Therapeutics launches Phase I clinical trial of anti-inflammatory compound
...of Medicine. To assess the anti-inflammatory and anti cytokine properties of CTI-01, subjects will be administered endotoxin, a cell wall lipopolysaccharide of Gram-negative bacteria that has been shown to induce an inflammatory response in humans and other species. "This Phase I study gives us a gli...First clinical trial of intravenous rViscumin under way in Germany and France
...rferon gamma, and is also associated with inducing anti rViscumin antibodies. So we are seeing a definite immune system response to the drug, although at this stage it is far too early to draw any conclusions about possible clinical significance or benefits to patients. This observation will have to be co......significant therapeutic benefits over an unlabeled anti CD-20 antibody," said Mark S. Kaminski, M.D., professor of internal medicine and co-director of the leukemia/lymphoma bone marrow transplant program at the University of Michigan Cancer Center. Hematologic toxicity was observed in a greater number...