UCSF Comprehensive Cancer Center program triumphs
...tate cancer; a project to develop novel engineered antibodies to fight cancer; and research on an antibody that stimulates an immune-system response against prostate cancer. The programs also include an investigation of which genes contribute to prostate cancer and a study of genes that confer susceptibility to...AIDS vaccine study harnesses 'killer' immune cells to control virus, prevent disease in animals
... The Proceedings paper also showed high levels of antibodies in vaccinated animals. However, the virus mutates so quickly that antibody immunity -- which forms the basis of most other vaccines -- is believed to be too restricted in its ability to recognize viruses to be effective in controlling HIV infections....Studies at UNC plumb tumor resistance to treatment
...then biopsied, usually the next day. Using special antibodies to pimonidazole that Raleigh developed and patented, tumor cells bound to the chemical can be detected by a laboratory immunoassay. Essentially, the test identifies the antibodies, which serve as markers for hypoxic cells. In Boston, MA, October 2...New patent will help improve cancer, transplant research
... attaching magnetic particles to antibodies that will seek out those cells and bind with them. Those cells are then delivered to a region of very high magnetic field. Researchers can identify the type of cell by measuring how fast the...Aslera™ improves lupus disease activity and symptoms
...onth review period. In lupus, the body develops antibodies that react against a person's normal tissue, which can lead to inflammation, arthritis pain, tissue injury and major organ damage. Common signs and symptoms of disease that lupus sufferers experience - severe fatigue, arthritis, facial rash, fever, s...Aslera™ improves bone mineral density in lupus patients
...d Chief Medical Officer. Lupus patients develop antibodies that react against their own normal tissue, which can lead to inflammation, arthritis pain, tissue injury and major organ damage. In addition to the risk of osteoporosis from age and steroid drug therapy, lupus patients can experience disease symptom...Hopkins scientists show enzyme is key to hallmark of Alzheimer's
...ed nerve cells from the animals' brains and, using antibodies targeted to beta-secretase, confirmed the enzyme wasn't present. As expected, the nerve cells lacking the enzyme failed to form beta amyloid, the plaque protein. "The mice without beta-secretase genes are born apparently normal and seem to suffer...Hopkins researcher finds bone disease and growth defect may have common genetic basis
... inside or on the surface of cell membranes. Using antibodies to selectively hunt down Gs-alpha and bind to it, they compared the concentrations of Gs-alpha in the red blood cells with that of normal red blood cells. In both girls, red blood cells contained about half as much Gs-alpha as normal red blood cells....Explaining the persistence of Hepatitis C
...ell culture assay. They also show that a blocking antibodies to the core protein or to gC1qR can abolish this e..., raising the question of why endogenous anti-core antibodies do not have a similar protective effect in infected individuals. Nonetheless, in light of the earli...Simpler HIV drug regimen may improve results, Science study on monkeys suggests
...itial infection, when the body has produced enough antibodies to temporarily quell the virus) to start the STI-HAART treatment. "Such a delay may raise questions in terms of appropriateness in treating humans, but represents a more realistic scenario," Lori said. One group of six monkeys was treated continuous...Diagnosis on a chip - molecular profiling that could improve diagnosis and help design better drugs
...easure the concentrations of specific proteins and antibodies in complex solutions such as blood samples. In an...fluorescent dyes and applied to the slide. As the antibodies and antigens begin to interact with each other, the type and number of specific proteins in the samp...UC Davis study shows spirulina boosts immune system
...ed response includes the activation of T-cells and antibodies that work with macrophages, another type of immune system cell, to engulf invading micro-organisms. Hence, spirulinas strength in protecting against intracellular pathogens and parasites. The moderate increase in the secretion of interleukin-1b, a cy......o this ancestor's genome, allowing it to crank out antibodies generated by transposition reactions. Agrawal's discovery, shared with her Yale University adviser, David G. Schatz, and colleague Quinn M. Eastman, was made possible by a unique petri-dish system for studying the chemical steps involved in genetic r...Infections may trigger autoimmunity via rare, but normal process
...an activate this group of cells to begin producing antibodies against self, perhaps triggering full-blown autoim...on in the mice. Normally, a powerful first wave of antibodies is produced by B cells in response to a new infection, with concentrations rising rapidly in the blo...DNA arrays decipher genome's master switches
... molecular soup of DNA-protein complexes. Specific antibodies coupled with magnetic beads are then used to fish out DNA fragments cross-linked to proteins of interest. This provides researchers a pure population of DNA-protein complexes, and unhooking the cross-linked DNA from the protein leaves them with DNA ......ntraceptive vaccine, they were trying to stimulate antibodies against mouse eggs, which would make the animals infertile. The mousepox virus was merely a vehicle for transporting the egg proteins into mice to trigger an antibody response. The researchers added the gene for IL-4 to boost antibody production. The...Scientists discover potent protein that prevents HIV infection
...results also suggest a new strategy for generating antibodies against HIV, which may be useful in vaccine development. Next Step Now that the researchers know that 5-Helix is a potent inhibitor of HIV in cell culture against a wide variety of HIV isolates, the next step is to find out whether or not it has ant...Study sheds new light on Lyme disease transmission
...k feeds on a OspA-vaccinated individual or animal, antibodies that have developed in response to the vaccine enter the tick gut and kill the bacteria inside the gut before the population has a chance to diversify. This prevents the transmission process from taking place, de Silva explained. De Silva pointed ou...With HIV rising, UMBI tailors vaccine for Nigeria
...logies developed at the IHV to elicit high-potency antibodies to HIV have been introduced into HIV's Nigerian vaccine formulation. With these novel components, IHV anticipates that the vaccine will induce strong antiviral immunity to HIV. Agwale, who was born and raised in Nassarawa State, Nigeria, conducted...Cancer-linked BRCA2 gene plays previously unsuspected role in cell division
... the activity of BRCA2 and BRAF35 using customized antibodies specific to each of the proteins. Between 450 and 600 individual cells were injected with the antibodies in the experiments. They then compared these cells to control cells. In the control cells, the resea...