Tag: "antibody" at biology news

Duke Researchers Discover Candidate Susceptibility Gene For Autoimmune Disease

...earchers injected the TTP-deficient animalswith an antibody that neutralizes TNFa. In a dramatic and almost completereversal, all signs of disease completely disappeared. The findings support preliminary results of human clinical trials beingconducted at Duke and other research institutions of an experiment...

Huntington's Disease Findings Pave Way For Potential Cure

...nuclear inclusions(NII). Analysis using monoclonal antibody technology not available in 1979revealed that NIIs were aggregates (clumps) of huntingtin protein. The proteinentered the cell nucleus through pores in the nuclear membrane. The NII werepresent in the brain cell nuclei of mice with symptoms very s...

Evolution Re-Sculpted Animal Limbs By Genetic Switches Once Thought Too Drastic For Survival

...ds of crustaceans we eat." The researchers used an antibody that labels the proteins made by two closelylinked homeotic genes, Ubx and abdA, to show in which segments of the embryo thegenes are turned on. The Ubx-abdA genes--like other homeotic genes, includingthe one that can cause a fruit fly to grow a leg ...

Virologists Track New Influenza Threat

...The H5 virus is frightening because people have no antibody protection against this type. Any time a new influenza type is introduced in people, it raises the possibility of a larger epidemic. On top of that, Hinshaw said this H5 strain is ...

Chlamydia Vaccine Developed At UMass

...to produce a hybrid cell that produces the correct antibody and reproduces itself endlessly. The body recognizes this antibody as the original GLXA itself. "Essentially, weve created an easy-to-handle protein molecule w...

STS-89 Will Carry Five Science Payloads From NASA/Marshall

...een able to define the structureof the recombinant antibody that fights respiratory synctial virus (RSV),the m...000 infantsdying from it. The active region of the antibody has been defined, whichwill help scientists to develop smaller, more easily made molecules thathave ...

Wistar Scientist Invited To Speak On Regeneration At National Meeting Of American Association For The Advancement Of Science

...as well. Yet, when the researchers use a specific antibody todeplete a subset of T-cells, which are the cells responsible for cell-mediatedimmunity, the mice heal perfectly. "It is intriguing to speculate," says Dr. Heber-Katz, "that repair of woundsbecame dominant in mammals with the development of a comp...

Researchers Take Major Step Toward Cracking Ebola Code

...detected by its ability to bind to cells, using an antibody tothis viral gene product. The binding characteristic of the transmembrane (orvirus-bound) form of the protein was detected by using a technique of moleculargenetics to insert this protein on the surface of another virus---a mouseretrovirus---which ...

Long-Standing Puzzle Of Immune System Is Solved By UCSF Researchers

...tations to potentially generate 4million different antibody proteins. B cells that produce the antibodiesthat.... The generation of mutations resultsin additional antibody diversity and serves to refine this clonal selectionover time, Wabl, Steinberg and most other geneti...

Study Shows: Just Say NO To Bone Loss

...e Patricia Collin-Osdoby, Ph.D.,added a monoclonal antibody the team isolated and developed to osteoclast cellsbelieving that the antibody would hone in on a target molecule it recognizes inthe osteoclast cells. This target molecule is ca...

Liquid Crystals Light Up Simple Chemical Test

...a liquid crystalassay that would report whether an antibody -- a molecule like those producedby the human body in response to an infection -- was present in a test sample. First the researchers spread an ultrathin layer of gold atop an inch-squareglass plate, creating a microscopic landscape of gentle, paral...

Scientists At The Scripps Research Institute And R.W. Johnson Pharmaceuticals Develop New Antibacterial Agents

...one or more of these virulence factorsby mutation, antibody neutralization or chemical inhibition can be thedetermining factor in tipping the outcome of the infection favorably toward thehost. As a consequence, we are gaining an appreciation for the potentialusefulness of bacterial virulence factors as new ta...

Yerkes Primate Research Center Of Emory University Reseachers Find Hunger Regulated By Novel Neurotransmitter

...kes on appetite, the rats' feedingincreased. "This antibody data is what makes us think CART is responsible, at least partially, formaking you feel sated -- whether it's after eating, or perhaps after cocaine use," explains Dr.Lambert. To further support the evidence that CART plays a major role in influenci...

Wistar Research Yields Information About Colorectal Cancer Cell Invasion

...an abundance of the GA733 antigen. Bydesigning an antibody that recognizes and attacks the antigen, Dr. Herlyn'sresearch team has successfully increased the survival rate of CRC patients in arandomized clinical trial. Despite the success of the antibody, however, littlehas been known about the function of t...

HIV Discriminates Amongst Cells

...e, the team labeled the receptors with fluorescent antibody tags and tookphotographs through a specially designed microscope. Cytochalasin D, a compoundthat prevents actin filaments from forming, was used to inhibit the movement ofCD4 and fusin. It also blocked viral entry. -...

Novel Drug Trial To Treat Advanced Prostate Cancer Enrolling Patients At UCSF/Mount Zion Cancer Center

... prostate tumor cells. In laboratory studies, the antibody didinhibit the growth of human prostate cancer cel.../Mount Zion Cancer Center. "We hope that anti-VEGF antibody will disrupt blood vessels and help slow orstop the growth of prostate cancer." The anti-VEG...

Crystal Structure Of Key HIV Protein Reveals New Treatment Targets

... receptor-bindingregions of the gp120 surface from antibody attacks. Finding a way around thesemolecules, or even removing them, would be another line of attack against thevirus. A structure that gp120 uses to attach itself to CCR5, a co-receptor needed tobind CD4 sites on the host cell. Because this stru...

Brain Antibodies Provide New Clues To Origins Of Tourette's

...nfirm or clarify potential associationsbetween the antibody and clinical symptoms or a particular infection, Singersays. He hopes to study antibody levels over time to see if they rise as ticsbecome more pronounced. He also hopes to identify the p...

Pediatric Anesthesiologists Risk Halothane-Related Liver Injury

...ith hepatitiscaused by exposure to halothane. The antibody level in the doctors was similarto that of one in five patients tested who had halothane hepatitis. However,none of the anesthesiologists showed signs of outright liver disease. "It's still too early to tell whether the antibodies mean theane...

NASA Research Helps Map Protein Structures -- Key In The Development Of New Disease-Fighting Drugs

...e structure of a potentially important therapeutic antibody to thedisease. This knowledge will permit scientists to understand key interactionsbetween the antibody and the virus, facilitating development of treatments forthe disease. Factor D prote...

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