Scientists at The Scripps Research Institute discover a previously unknown role for antibodies
...tes, such as lupus." Based on their examination of antibody and T-cell receptor x-ray crystal structures, the authors propose a conserved site within the antibody structure where they believe the singlet oxygen binds and where the catalytic process is initiated. ...Regulation of vascular tone by a secreted mitochondrial peptide
...tensive rats, and the authors show that a blocking antibody to the peptide can lower blood pressure in these animals, as well as in healthy controls. Recombinant peptide, conversely, induces hypertension, apparently by suppressing the synthesis of the vasodilator prostacyclin while leaving other aspects of p...Researchers reveal new clues about spread of colon cancer
...d separating cells based on their attraction to an antibody specific for colorectal epithelial cells in liver tissue, which constitute the metastatic cancer cells. "Once we did this separation," said Vogelstein, "the gene expression patterns became much clearer and more reliable." SAGE analysis of these isol...New DNA-base vaccine approach protects mice against anthrax
... last injection, researchers measured the groups' antibody response to both gene products...s wrote, "titers (measures) of antibody to the LF antigen appeared to be about twice those of antibody to the PA. This s...Study: Infected people need not carry AIDS virus long before passing it on
...cted or infectious just because you had a negative antibody test for HIV," he said. "The most commonly used tests can't show HIV for several weeks." The National Institutes of Health, the UNC General Clinical Research Center, the UNC and Duke Center for AIDS Research, the Swiss National AIDS Research Program......ls were inoculated with the Seoul virus as adults; antibody responses and viral prevalence were assessed in both sexes. Castrated males displayed female-type responses, i.e. lower concentrations of anti-virus responses with less virus shed than in the control male population. On the other hand, injecting t...Anthrax - How to protect ourselves
... There are some "quick and dirty" field tests. An antibody test can give results within 15 minutes. But Bacil...sults don't prove spores were absent. Both DNA and antibody tests rely on cracking open the tough spores. But the solutions used to do this can inhibit the PCR ...Yale researchers develop new molecule that eradicates cancer by destroying tumor blood vessels
... other part of the icon is the region of a natural antibody that activates an attack by the immune system against cells that bind to the icon. "The result is that the tumor blood vessels are destroyed by the immune system and consequently the tumor cells die because they lack a blood supply," said Garen. "Th...Highly specific biological agents attack mechanisms of treatment resistance
...ts their tumor to grow. Herceptin is a monoclonal antibody that binds to HER2 and suppresses its growth signal. Were looking for ways to enhance the clinical benefit of Herceptin, such as attaching to it agents that might be synergistic, such as DM1, a compound that blocks cell division, said Ralph H. Schw...Hepatitis E recovered from rats in Los Angeles
... For the next step they must develop a specific antibody diagnostic for the rat virus and test humans with it to see if they have been infected by the rat virus. Exposure does have its upside. Having antibodies to HEV, regardless of the source, appears to protect against future disease. In a related st...Antibodies to liver stage associated with malaria resistance
...r Reed Project in Kenya hypothesized that a strong antibody response to LSA-1 might be associated with high le...parasites. The data showed a relationship between antibody levels and infection. "If you were one of the lucky few to have a high level of antibodies to LS...Science: nanoscale 'Trojan Horse' attacks cancer cells from within
...active atom of actinium chemically harnessed to an antibody that zeros in on and penetrates only specific cancer cells. Inside the cell, the actinium decays by giving off alpha particles--very small, high-energy particles that rip through the cell and destroy it. Actinium's decay produces a series of three "d...Nuclear medicine aids early diagnosis of pulmonary anthrax
... assess the efficacy of a 99mTc-labeled monoclonal antibody in imaging early-stage inhalation anthrax infectio...s (Princeton, NJ) is the maker of the radiolabeled antibody product, Leutech™, that will be used in the WRAMC investigation and is the company to which the...Durable responses reported with Bexxar
...darabine), radiation (Iodine-131) and a monoclonal antibody (tositumomab) [ASH Abstract #3505]. All patients ...y of treatment with either Bexxar or its unlabeled antibody component, tositumomab. Seventeen percent of patients enrolled in this trial presented with transfo......whose interferon-gamma protein was blocked with an antibody both had larger hearts and more physical evidence of heart tissue inflammation than mice with normally functioning interferon-gamma, says Afanasyeva. They're still evaluating the effects on heart function, she adds, and they don't yet know whether i...Monitoring epithelial plasticity, one cell at a time
...e authors examined the effect of a hensin blocking antibody in their ex vivo system. They confirm that this antibody specifically inhibits the conversion to the a cell phenotype. Hensin is ubiquitously expressed, gene...... is a target for Herceptin, a humanised monoclonal antibody designed to lock onto the receptor. Herceptin is increasingly used, either alone or combined with conventional chemotherapy, to combat advanced breast cancer. Another growth factor receptor the epidermal growth factor receptor (EGFR) - is involved ...Genetica, Inc. develops high throughput RNAi tool for drug target validation
...e technologies, a retroviral tool called CELLx, to antibody production. Gregory Hannon, Associate Professor at Cold Spring Harbor Laboratory, principal investigator in the new study, and a founder of Genetica says, "RNAi has emerged as a highly promising research tool for determining gene function. Our resear...'Flap' on protein suggests new therapies for autoimmune diseases
...ll-1s ability to trigger maturation of B cells and antibody production, said Gongyi Zhang, Ph.D., Assistant Pr...ical trials of Tall-1, which it calls BlyS, and an antibody to Tall-1.......es, so they were only able to make the one type of antibody or receptor they started out with. "This tells us that the original B cell and T cell were truly mature, functional cells waiting to get activated by a pathogen," explains Hochedlinger. Implications "In normal cloning attempts, it would be too ineff...