New method of DNA testing promises to transform medical diagnostics
...aid, "operate not by DNA detection, but protein or antibody detection. For each possible infecting agent, a whole system has to be devised. A person is infected; that person's immune system makes antibodies. Somebody has had to figure out what those antibodies look like and what antigens they bind to, and ...First drug developed for widespread use against botulism
...es against botulinum toxin and combined them. Each antibody is capable of binding to a different part of the t... block far more of the toxin surface than a single antibody could, the scientists report. As a result, in animal studies, the antibody "cocktail" neutralizes mu...New approach to malaria vaccine effective in mice
...rchers found that the anti-GPI vaccine provoked an antibody response in mice. Their results suggested that the GPI from the malaria parasite was sufficiently different from the mouse's own GPI molecules to be recognized as foreign. The researchers also tested the effects of antibodies from mice immunized with...UW scientists find genetic pathway to potent anticancer agents
...d to a particular target. It can be tethered to an antibody which then directs it to the cancer cell," Thorson explains. The ability to precisely home in on cancer cells with such small amounts of a drug may also help limit some of the unpleasant side effects of chemotherapy such as nausea and hair loss. Memb...Dipsticks for water testing, right whale future grim, marine law center established
...will simplify the testing process by developing an antibody or "dipstick" style test to monitor for these toxins. "Our goal is to develop effective monitoring measures that can be employed by water quality managers, conservation agents and health officials to rapidly screen for the presence of cyanobacteria,...New antibacterial coating may prolong contact lens life
..." Although very preliminary, attaching selenium to antibody peptides shows potential for AIDS treatment, according to Reid. "We've tested it on the AIDS virus and shown that it will inactivate the AIDS virus in culture. We're also sending some of this back to NIH [National Institutes of Health] and they're g...FDA clears for market new diagnostic test for lupus
...of the blood. The test, called the Anti-SR protein antibody assay, involves adding sera to tiny wells in a plastic plate that has been coated with human SR proteins. A colored molecular tag detects antibodies in the sera that stick to the SR proteins. Sera from people with lupus turns purple, while sera from ...Nutrition and exercise boost effectiveness of flu shot in older people
... potential benefit to older adults due to improved antibody responses to the influenza vaccines, reports a stu...oes not always result in adequate protective serum antibody in older adults. However, in healthy, well-nourished elderly people, there is only a small decline i...JCI table of contents: October 1, 2002
...ccompanying Commentary :Antineutrophil cytoplasmic antibody and vasculitis: much more than a disease marker Vivette D'Agati Columbia Univ Col P and S 630 W 168th St New York, NY 10032 USA Phone 1: 212-305-7460 E-mail: vdd1@columbia.edu See PDF of the article at: https://www.the-jci.org/press/15918.pdf a...Sydney Brenner, Molecular Sciences Institute founder, awarded the Nobel Prize
...o made great contributions to the understanding of antibody diversity. During the 1980s and 1990s, he was one of the people most responsible for the genome sequencing projects and the information that they produced. It was in part the success of these sequencing projects, together with the molecular biologica...Tips from the Journals of the American Society for Microbiology
...clinically," say the researchers "However, passive antibody therapy holds promise." (J. Mukherjee, K. Chios, D. Fishwild, D. Hudson, S. O'Donnell, S.M. Rich, A. Donohue-Rolfe and S. Tzipori. 2002. Production and characterization of protective human antibodies against Shiga-toxin 1. Infection and Immunity, ...UCSF-led team reports new test improves detection of prions in animals
...fectious prion protein in its natural state to the antibody and measuring the reactivity. Next, the prion protein is unfolded by chemical means so that the hidden region is exposed. Predictably, the antibody's immunoreactivity to this denatured region, as measured by its degree of binding to the molecule, is ...JCI table of contents, October 21, 2002
...alization of the CCR9 ligand CCL25 with a blocking antibody inhibitsthe accumulation of these cells in the small intestinal epithelialcompartment. These results provide direct in vivo demonstration of afunctional role for a chemokine/receptor pair in lymphocyte localization tothe intestinal mucosa. CONTACT: ...FDG PET reassures and reveals high risk multiple myeloma
...tion, in which there is excessive production of an antibody protein by abnormal plasma cells, evolves into multiple myeloma about 20% of the time. All had negative PET scans at their first evaluation. Only one of the patients scanned developed multiple myeloma during the follow-up period. The authors conclud...Aspirin inhibits ovarian cancer growth, lab study finds
...lso found that combining aspirin with a monoclonal antibody specific for the HER-2/neu protein created even greater suppression of growth than treating the tumor cells with aspirin alone. This combination decreased ovarian cancer cell growth by 84 percent. HER-2/neu is a receptor protein on the tumor cell su...Acorda Therapeutics acquires CeNeS neuregulin products
...am, which includes the M1 remyelinating monoclonal antibody technology. Together, these technologies give Acorda a dominant position in remyelinating therapeutics. Current MS therapies work by slowing the progression of the disease but do not address the permanent demyelination that leads to the disabilities ...Study shows first direct evidence that transplanted muscle cells can take root in damaged hearts
...letal muscle are two distinct types of tissue, the antibody test shows conclusively that the transplanted skeletal muscle satellite cells survived." The transplanted cells also appear to have begun forming vascular muscle cells, which make up the walls of blood vessels. In areas where cells had been injected,...Critical therapeutics is awarded U.S. patents for methods to diagnose and treat inflammatory disease
...vides a pharmaceutical composition comprised of an antibody that binds HMGB1. The antibody, in turn, is believed to dramatically reduce the "cytokine cascade," or overproduction, of HMGB1 that triggers sepsis and other inflammatory diseases. U.S. patent number 6,448,223 B1, "Antagonists of HMGB1 for Treatin...JCI Table of Contents, December 2, 2002
...*************** A monoclonal thyroid-stimulating antibody Autoantibodies that activate the thyrotropin rec...se, Takao Ando andcolleagues isolated a monoclonal antibody that is a potent activator of thethyrotropin receptor. Like the autoantibodies, the monoclonal antib...... The researchers tracked levels of HDM2 using an antibody technique that tags the molecule with a colored stain. The molecule is involved in the pathway for a tumor suppressor gene called p53, which, when mutated, is associated with many cancers but not melanoma. It is not clear why HDM2 levels would be hig...