Tag: "antibody" at biology news

UIC scientists provide first images of HIV in living cells

...s role was confirmed by injecting an off-the-shelf antibody into the cells that prevents the molecular motors from working. When the motors stop, the viral particles are found scattered throughout the host cells, not congregated around the cells' nuclei. The paper represents four years of research, begun when...

Observing proteins and cells in the wild

...uld then attach the dots to their protein-specific antibody of choice. The critical test was to determine spec... were incubated with quantum dots conjugated to an antibody specific for that membrane protein, the pattern of GFP fluorescence matched the fluorescence of the ...

Wistar-developed antibody shows promise against brain tumors in Drexel trial

... injections of MAb425, a radioiodinated monoclonal antibody developed at The Wistar Institute. All of the pat... alive after 56 months. "It's gratifying to see an antibody discovered in a Wistar laboratory showing such promise in the clinic against difficult-to-treat brai...

Blasting antibodies with lasers provides direct way of measuring their flexibilities

... like this one to carefully examine the details of antibody recognition of antigen at the molecular level, whi...e number of atoms within a molecule the size of an antibody is so large that drawing conclusions from the data is nearly impossible. Now Romesberg, Baldridge, ...

JCI table of contents, December 15, 2002

...t lack of alpha1beta1integrin or its blockage with antibody attenuated disease in a mouse modelof colitis. Thi...hat effectivelycompetes with cell-surface aGal for antibody binding. On pages 1869-1877 theauthors report that in different monkey species, injections of GAS914...

A new study sheds light on how the tongue restores its ability to taste following surgery

...sitive period(s). To accomplish this, a monoclonal antibody to keratin 19 was used to immunohistochemically label taste buds at various times after unilateral CT section. Keratins are intermediate filament proteins expressed in a range of epithelial tissue, with specific sequences present during various state...

Chicken pox vaccine OK for children with kidney disease

...ed the varicella antibody, and 87 percent retained antibody levels for more than three years. Although kidney ...ansplant recipients tended to have lower varicella antibody levels during the first two years of follow-up, researchers report that antibody levels increased ov...

Acorda therapeutics receives NIH Phase 2 grant for central nervous system repair

... antibodies after the onset of demyelination. The antibody treatment produced a robust remyelination in these mice. "Current MS therapies work by slowing the progression of the disease but do not address the permanent demyelination that leads to the disabilities associated with that condition. The antibod...

Growing human antibodies in algae

...rch Institute (TSRI) have used algae to express an antibody that targets herpes virus, describing the work in ...ceedings of the National Academy of Sciences. This antibody could potentially be an ingredient in an anti-herpes topical cream or other anti-herpes treatments, ...

Emory Vaccine Research Center study identifies specific gene required for long-term immunity

...that the SAP gene is a central player in long-term antibody responses, and indicates that manipulation of SAP ...may have therapeutic benefits in generating better antibody responses." Crotty and his colleagues compared the immune responses of the knockout mice against th...

New antibody library speeds search for new detection tools

...e blood cells as part of the immune response. "Our antibody library offers many advantages over traditional ap... method, PNNL scientists can readily modify how an antibody binds to proteins. Being able to increase how tightly a protein and antibody bind together, for exa...

Newly discovered cellular process helps cells respond to DNA damage

...ation." The St. Jude researchers also developed an antibody that specifically recognizes activated ATM, and thus identifies only those ATM molecules that are responding to DNA damage. "Our technique for identifying activated ATM is so sensitive that we've been able to show that it takes only a couple of break...

Antibodies critical for fighting West Nile Virus infection

...his is just speculation that humans who have weak antibody responses early during infection are more likely to develop serious disease," says Diamond. "Those are the people we'd want to target when a vaccine or treatment becomes available." Diamond and his colleagues now are studying how antibodies control i...

UT Southwestern researchers developing new procedures to make bone-marrow transplants safer

...ions. Immunotoxins are drugs created by linking an antibody to a portion of bacterial or plant toxin to destroy cells expressing the molecule to which the antibody binds. "One of the major goals the Holy Grail of bone-marrow transplantation is to separate graft-...

The Fragile X syndrome protein as RNA distribution hub

...n attached to a photocopier: Eberwine connected an antibody that specifically binds to FMRP to a DNA molecule that can bind to the RNA near the FMRP protein. In the presence of enzymes, the DNA molecule helps copy these RNAs into cDNA (a term for DNA made from RNA). After it is synthesized, the cDNA is ampli...

Cell density determines extent of damage caused by cigarette smoke exposure

... densities. To investigate the effect of anti-TGF antibody on fibroblast-mediated gel contraction, the researchers added TGF antibody (10 g/ml) to the culture media after gels were released. Antihuman IgG antibody was used as control....

Causation between white blood cells and lung disorders confirmed

... lung (local)] of a rat anti-mouse CCR3 monoclonal antibody resulted in the abolition of eosinophils from the lung such that the airway lumen was essentially devoid of eosinophils. This procedure caused perivascular/peribronchial eosinophil numbers to be reduced to levels indistinguishable from saline-challe...

Genetically engineered mice offer hope for isolating beta cells and treatment of type 2 diabetes

... with a polyclonal guinea pig anti-porcine insulin antibody to identify -cells and with polyclonal rabbit anti-human glucagon, somatostatin, and pancreatic polypeptide antibodies to identify - and PP-cells, respectively. Results This research produced transgenic mice in which pancreatic -cells are genetic...

Structure of key breast cancer receptor determined

...now exactly which building blocks of the Herceptin antibody interact with which building blocks of HER2," says Dan Leahy, Ph.D., professor of biophysics and a Howard Hughes Medical Institute investigator at the Johns Hopkins School of Medicine. "When you understand the properties of receptors and antibodies i...

Allergen-free shrimp? seafood marks a place in food safety research

...llergenic portion of the moleculethat bind with an antibody called immunoglobulin E (IgE). The reaction that r...for the different molecules that interact with the antibody IgE. By altering the epitopes in shrimp allergens that bind to IgEby just one amino acidthe binding ...

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