The search for a kinder, gentler chemotherapy
..."In the lab right now we're loading particles with anticancer agents and understanding the fundamentals of how the particles can encapsulate them, how tightly they can hold onto them and how closely we can regulate the uptake and release," said Lyon....Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
...t since SUL's actions appear similar to a group of anticancer drugs currently in use, such as Taxol," Singletary...ain natural compounds or drugs could enhance their anticancer effectiveness and reduce side effects." According to the American Cancer Society, breast cancer this...Bright idea could doom cancer and viruses, say Purdue scientists
... years away, the compounds could have potential as anticancer agents and for blood sterilization. "We have proven in principle that light and chemistry together can destroy tumor cells and the Sindbis virus, a member of a group of viruses that cause encephalitis, fever and arthritis," said Morrison, who is prof...Anticancer drug zebularine specifically targets tumor cells
LOS ANGELES, August 23, 2004 A novel anticancer drug that inhibits a process known as DNA methylat...d cancer cells and may hold clinical promise as an anticancer therapy," the researchers wrote. Zebularine's inhibition of DNA methylation was first discovered in ...Other highlights in the August 18 JNCI
...ase gene silencing could be a potential target for anticancer drug development. Contact: Israel Vlodavsky, Bruce Rappaport Faculty of Medicine (Technion, Haifa), 972-4-829-5410, vlodavsk@cc.huji.ac.il Researchers Study Molecular Mechanisms Involved in Medullary Thyroid Carcinoma In a new study of medullary......t many of these natural organohalogens have potent anticancer and antibacterial activity, and one organochlorine, vancomycin, is the life-saving drug for treating penicillin-resistant bacterial infections in hospital patients. "The first edition in 1996 had about 2,400 compounds," he says. "The new e...Other highlights in the July 7 JNCI
...an still be tolerated. New targeted, non-cytotoxic anticancer agents, such as small-molecule kinase inhibitors, ...blished phase I studies of targeted, non-cytotoxic anticancer agents. They found that the majority of studies used the traditional endpoint of toxicity to determi...UCSD team determines cellular stress within body is critical
...t an exciting new target for the identification of anticancer drugs." In describing his team's research, Ho said that it was previously thought that the kidney was the only tissue in the body that was subject to osmotic stress. The kidney controls how much water and salt is in our blood using a mechanism that ...New designed paclitaxel analog kills more cancer cells than natural product
...mpound from yew trees, is the world's best-selling anticancer drug. Several analogs are in clinical trial, with others in preclinical development. One problem that paclitaxel and all its analogs share, however, is that they are all highly complex compounds, and cannot be prepared synthetically in a commercially...Study finds first evidence COX-2 enzymes can regulate DNA damage
...terest in the potential use of COX-2 inhibitors as anticancer agents was fueled in part a decade ago when an American Cancer Society study showed that regular use of aspirin led to an unexpectedly low incidence of colon cancer. But all was not rosy. In addition to inhibiting the production of COX-2, aspirin als...Small RNA surmounts large cancer problem
...m of drug resistance when used in conjunction with anticancer agents....Study investigates breast cancer resistance to tamoxifen and possible way to reverse it
...tinib (Iressa)--may be able to restore tamoxifen's anticancer activity. The study appears in the June 16 issue of the Journal of the National Cancer Institute. Although adjuvant tamoxifen can reduce the risk of death for women with invasive breast cancer by about 15% over 10 to 15 years, many women do not rec...JCI table of contents, 15 June 2004
...m of drug resistance when used in conjunction with anticancer agents. TITLE: Stable expression of small interfering RNA sensitizes TEL-PDGFbetaR to inhibition with imatinib or rapamycin AUTHOR CONTACT: D. Gary Gilliland Brigham and Women's Hospital, Boston, Masachusetts, USA. Phone: (617) 355-9092; Fax: (617) 3...Pharmacogenomics could replace 'trial-and-error' with science from the human genome
...er cells that are either sensitive or resistant to anticancer agents, while other genes are under-expressed, or relatively inactive," Evans said. "Drugs designed to target the genes that are over-expressed in drug-resistant cancer cells would make logical targets for new anti-cancer drugs in an attempt to rever...Cancer drug resistance research leads to possible therapeutic target for Alzheimer's disease
...rotein that allows human cancer to resist multiple anticancer drugs also appears to play a key role in Alzheimer...circumventing mechanisms of cellular resistance to anticancer drugs and understanding cellular pathways that affect drug response and resistance. The new report ...Other highlights in the May 19 JNCI
...hown that vitamin E, a mixture of tocopherols, has anticancer effects that are believed to stem from its ability...mans, a new study provides clues to the chemical's anticancer abilities by showing that a diet that includes supplements of alpha-tocopherol, but not gamma-tocoph...Inhibition of cathepsin proteases inhibits tumor formation in transgenic mice
... point to cathepsins as a viable target for future anticancer therapeutics. According to Dr. Hanahan, "It is reasonable to suggest that cathepsin inhibitors may show combinatorial benefits with other targeted (and traditional) therapies, which could be revealed in preclinical trials involving this and other mou...'Crystal engineering' helps scientists solve 3-D protein structures
...ield a much more accurate structure of a potential anticancer drug target called insulin-like growth factor-1 receptor. Development of the technique was made possible by funding from NIGMS' Protein Structure Initiative (PSI)--an ambitious 10-year project, launched in 2000, aimed at dramatically reducing the tim...... The research has exciting implications for future anticancer therapies that may stimulate an effective immune response against tumor cells. Tumor cells enhance their own survival by somehow escaping attacks from the immune system of the host. A molecule called galectin-1 (Gal-1) has a negative influence on imm...