Leader in cancer treatment and prevention research honored
...rcinogenesis, including proliferating cell nuclear antigen (PCNA), p53, polyamine levels, and apoptosis. Together with his research group, the Chemoprevention of Skin Cancer Program Project, he developed topically administered chemopreventive agents that can be incorporated into sunscreens. Dr. Alberts also...Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
...ional innate immune response, but it also puts the antigen into exactly the pathway we want and gives us a ro...cancer vaccines. In fact, Cook said, as long as an antigen can be found that stimulates an immune system attack against a cancer, that antigen could be inserte...IBD (Crohn's, Colitis) 'joins' cancer, inflammatory diseases in associated blood vessel growth
... mucosa and immunostained them for the endothelial antigen CD31. Vessels were quantified by digital morphometry (vessel density/field). Microvessel V3 expression was studied in vivo by confocal microscopy, and in vitro by flow cytometric analysis of human intestinal microvascular endothelial cells (HIMEC) ac...Diabodies act as guided missiles targeted to mammary tumor growth
...However, the affinity that the diabody has for its antigen target is so great that a significant amount of th...r cells. "The dimeric C6.5K-A binds to its target antigen 40 times more tenaciously than its individual monomeric components, thus promoting prolonged retenti...JCI table of contents: 1 September, 2004
...aradoxical activities. The authors found that when antigen was present in the lymph nodes, and thus immune cells were activated and began to proliferate in the lymph nodes, there was a strong immunological response that ultimately was followed by the development of hepatitis. If, however, the antigens were i...Researchers uncover secrets of immune system's munitions factory
...call the immune system to arms. The presence of an antigen on the surface of a B cell stimulates it to produc...antibody molecule that direct it where to take its antigen cargo and how to dispose of it. A central mystery in the field of immunology, said Alt, has been how...Regular physical activity really does boost immune system in older men
...line in the primary antibody response to the novel antigen KLH as well as an age-related decline in the memor...portantly, antigen-driven responses, but not total antigen nonspecific Ig, were affected by age or exercise, suggesting this measure is truly reflecting altera...Nucleic acid-amplification testing further safeguards nation's blood supply
...ive tests to detect HIV and HCV antibodies and HIV antigen were implemented during the past decade, in rare i...ue two less effective screening tests — HIV-1 antigen testing and a test for a nonspecific marker for HCV. Blood donations continue to be screened with an...New mechanism for display of foreign proteins to immune system
...hen transported by the transporter associated with antigen processing (TAP) for display. However, there is some evidence that an alternative mechanism that does not involve TAP may also contribute to crosspresentation. A research team led by Dr. Kenneth L. Rock from the Department of Pathology at the Univers...JCI table of contents, 16 August, 2004
...le MIC level in serum related to prostate-specific antigen (PSA); PSA measurements are used as a biomarker fo..., antibody maturation through repeated exposure to antigen results in increased antibody affinity. Ezio Bonifacio and colleagues, from the Diabetes Research In...MICs shed light on prostate cancer
...le MIC level in serum related to prostate-specific antigen (PSA); PSA measurements are used as a biomarker for the presence of prostate cancer. Soluble MIC serum levels did not correspond with PSA serum levels, but they were highly correlative with high-grade and invasive tumor status in prostate cancer pati...New discovery may help transplants survive
...iece of the cancer puzzle. "It has been shown that antigen presenting cells around tumors also express VEGFR-3 and we already know that access to lymphatics and lymph nodes is the way cancers spread through the body," he says. "The findings of Dr. Dana and his colleagues provide new insights into transplant ...JCI table of contents, 2 August, 2004
...ates the Th2 response to epicutaneously introduced antigen AUTHOR CONTACT: Raif S. Geha Children's Hospital, One Blackfan Circle, Boston, MA 02115, USA Phone: 617-919-2482; Fax: 617-730-0528; E-mail: raif.geha@tch.harvard.edu View the PDF of this article at: https://www.the-jci.org/press/19082.pdf ----...Newly designed nanoparticle quantum dots simultaneously target and image prostate tumors in mice
... antibody targeted to a prostate-specific membrane antigen (PMSA) on the cell surface of the prostate tumor c...ed at the site of the tumor through binding to the antigen target. The new triblock polymer coating protected the quantum dots from attack by enzymes and othe...Scientists discover new intricacies in how ulcer bugs stick to stomach
...s to a carbohydrate structure known as the Lewis b antigen receptor. In humans with different blood types, this receptor either stands alone (blood type O) or contains additional sugars (blood types A and B), changing the shape of the target babA seeks to bind. "Most human populations have a mixture o...Crystal structure for anthrax-cell binding complex
...toxin is comprised of three proteins: protective antigen (PA), lethal factor (LF), and edema factor (EF). To gain entry into host cells, PA must recognize a receptor on the surface of the target cell. Once PA has bound to the cell, it then enables EF and LF to bind and form a pore through which PA forces...JCI table of contents, 1 July 2004
...for Tolerance TITLE: Tolerance induced by inhaled antigen involves CD4+ T cells expressing membrane-bound TGF-beta and FOXP3 AUTHOR CONTACT: Anuradha Ray University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Phone: 412-802-3191; Fax: 412-692-2260; Email: raya@pitt.edu View the PDF of...Herpes tool allows researchers to customize Alzheimer's vaccine
...unt of amyloid plaque in the brain. The additional antigen tweaked the immune response in a way that muted the original vaccine's harmful side effects. "From our studies and those of others, it appears that you need to induce specific immune activity to clear existing plaque or prevent the formation of new ...JCI table of contents, 15 June 2004
..., making them target and kill cells that have this antigen on their surface. Some DNA vaccines present the entire antigen gene. Minigene vaccines however, contain only a portion of the antigen gene and can provide greater ...... cancer in men with intermediate prostate-specific antigen (PSA) levels. Although PSA screening for prostate cancer has become widespread in the United States, the test has a high rate of false positives because benign diseases, such as prostate enlargement, can increase PSA levels. AMACR expression has been...