Novel approaches to current cellular therapies continue progress toward disease prevention
...y. In the 31 patients receiving adoptive therapy, antigen specific T-cells were present at near normal level...ecipients who received anti-CMV T-cell clones, CMV antigen activity became negative from two to three weeks after the infusion onward. Two patients who had CM...Scientists develop a novel strategy to help prevent transplant rejection
... where we down-regulate an unwanted response to an antigen rather than stimulate it. This represents a huge opportunity to benefit patients and build our company. We have been extremely pleased to be able to get strong financial support to move this important academic innovation into industry."...JCI Table of Contents, November 3, 2003
...ollowing stimulation with a previously encountered antigen were highly enriched for VLA-1+ cells. Furthermore, depletion of the small fraction of VLA-1+ cells present in the CD4+ peripheral blood lymphocyte population significantly reduced the immune response to previously encountered antigens. Therefore VLA...Fruits offer powerful protection from skin cancer
...; and protein levels of proliferating cell nuclear antigen (PCNA), all of which are established markers of tumor promotion. Resveratrol also further stimulated a UVB-mediated increase in p53 protein levels and was found to inhibit UVB exposure-mediated increases in cell cycle promoting signals including the...New therapies under development promise improved relief for Non-Hodgkins Lymphoma cancer patients
...advanced lymphoma therapeutics, are targeting CD20 antigen that may be found on normal, as well as abnormal B cells. In addition, other antigens such as CD4, CD22, and CD30 are being targeted. Some biotech firms are also trying gene therapy and vaccines to treat patients. These treatment methods could be adv...Ki-67 biomarker a strong predictor of outcome for prostate cancer patients
...City, Utah. The Ki-67 biomarker is a proliferation antigen that is detected by a process called immunohistochemical staining. When a tumor cell tests positive for Ki-67, the tumor is actively growing. Prostate cancers typically have very low percentages of growing cells and they grow slowly. Pollack and ot...JCI Table of Contents, 1 October, 2003
...osugar modifier of cutaneous lymphocyte-associated antigen AUTHOR CONTACT: Charles J. Dimitroff Harvard Institutes of Medicine, Boston, Massachusetts, USA. Phone: 617-525-5602 Fax: 617-525-5571 Email: cdimitroff@rics.bwh.harvard.edu View the PDF of this article at: https://www.the-jci.org/press/19220.pdf ...New method could aid in prostate and breast cancer diagnosis
...articles and DNA that can detect prostate specific antigen (PSA) when present at extremely low levels in a blood sample. This promising new protein-detection method could be used to monitor prostate cancer patients following surgery and to detect the early signs of breast cancer. Prostate cancer in men and b...Researchers solve the mystery of a key structure in immune system cells
...centration of binding sites, or receptors, for the antigen at the center of the synapse -- much like the cent...ceptors, so their T-cells over-responded to strong antigen signals. But Dr. Shaw's study was unable to show exactly why the defective T-cells weren't functioni...JCI Table of Contents, September 15, 2003
...ilize and clone themselves should the same foreign antigen be encountered during a subsequent infection. The authors concluded that the increased degree of proliferation of this T cell subset was the result of chronic immune activation and not the result of a mechanism striving to compensate for the loss of ...Researchers learn certain enzyme inhibitors may help in cancer therapy following initial procedures
...e and yielded very low levels of prostate specific antigen (PSA), a marker associated with malignancy. Cells treated with a similar compound that was not a telomerase inhibitor formed large tumors with high PSA levels. "Telomerase is widely appreciated as a promising target for therapy," said Dr. David Corey......28 molecule on the T cell with it's ligands on the antigen presenting cell a process known as costimulation. In contrast with nave T cells, memory T cells can be activated after engagement of the T cell receptor, without CD28-mediated costimulation. Andrew Fontenot and colleagues at the University of Colora...Dual action anthrax vaccine more effective
...odies (immunoglobulins) specific to the protective antigen and PGA antigens. They found that levels of PGA- a...at mouse blood containing antibodies to protective antigen protected cells against damage from anthrax toxin by blocking protective antigen. The findings appea...Study reveals genetic activity of key step in malaria parasite's cycle
...exity in the arrays of genes the parasite uses for antigen diversity," says DeRisi. "Identifying these zones of instability lays the foundation for dissecting the molecular mechanism by which malaria evades host immune processes, and may lead to better selection of antigens for vaccine development." The stu...Protein can predict progression of most common childhood brain tumor
...e likely to progress if large amounts of the Ki-67 antigen are present in cancer cells, suggesting that certain tumors are biologically predisposed to progress or reoccur, the UT Southwestern researchers report. The study one of the largest of its kind appears in the August edition of the Journal of Clini...Rice makes first rapid, sensitive whole-blood immunoassay
...ay containing antibodies that bind with a specific antigen under investigation. When the antibodies bind to the antigen, the test changes color. These systems are used to identify and diagnose various conditions ranging from HIV to a heart attack. Unfortunately, existing technologies haven't produced a fast,...Towards an AIDS vaccine: unusual antibody that targets HIV described by scientists at TSRI
...f the antibody in which its two Fab domains -- the antigen recognition units -- are 'interdigitating' with each other," says TSRI Professor Ian Wilson, D.Phil., one of two TSRI professors who led the research. "Nothing like this has ever been seen before." This new structure is an important step toward the ...Structure of HIV-neutralizing antibody solved
...ld provide scientists with a template to design an antigen that would trigger the body to produce 2G12. Antig...sts believe that it might be possible to design an antigen to entice the body to produce 2G12. Such an antigen could be the basis of a vaccine against HIV. Thi...JCI table of contents, 16 June 2003
...s a strong argument for the importance of previous antigen exposure in determining the outcome of protocols d...entary. We should expect that differences to prior antigen exposure will be only one of the potential reasons for marked differences that are encountered betwe......l response is dependent on the presentation of the antigen by host dendritic cells (DCs). As part of earlier strategies, the antigen of interest has been transferred to host DCs (by a process called transduction) outside the body and...